Save on this medicine
Other brands with the same active ingredient
These brands contain the same active ingredient (Erlotinib). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Ertinib 150 Tablet is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
NSCLC: The recommended daily dose of Erlotinib for NSCLC is 150 mg, taken on an empty stomach, that is, at least one hour before or two hours after eating. Treatment should continue until the disease progresses or unacceptable toxicity occurs. Pancreatic Cancer: The recommended daily dose of Erlotinib for pancreatic cancer is 100 mg, taken once daily in combination with gemcitabine. Take Erlotinib on an empty stomach, that is, at least one hour before or two hours after eating. Treatment should continue until the disease progresses or unacceptable toxicity occurs. Reduce Erlotinib in 50 mg decrements if severe reactions occur with concomitant use of strong CYP3A4 inhibitors (such as atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, voriconazole, or grapefruit or grapefruit juice) or when used concomitantly with an inhibitor of both CYP3A4 and CYP1A2 (for example, ciprofloxacin). Increase Erlotinib in 50 mg increments as tolerated for concomitant use with CYP3A4 inducers, such as rifampin, rifabutin, rifapentine, phenytoin, carbamazepine, phenobarbital, or St. John's Wort. Increase doses in 50 mg increments at 2 week intervals to a maximum of 450 mg. Avoid concomitant use if possible. Concurrent cigarette smoking: Increase in 50 mg increments at 2 week intervals to a maximum of 300 mg. Immediately reduce the dose of Erlotinib to the recommended dose (150 mg or 100 mg daily) upon cessation of smoking.
Side Effects
The most common side effects of Erloren, seen in 20% or more of patients across a pooled analysis of studies, were rash, diarrhea, loss of appetite (anorexia), tiredness (fatigue), shortness of breath (dyspnea), cough, nausea, and vomiting. Serious side effects have also been reported, some of which may be fatal. These include interstitial lung disease (ILD), renal failure, hepatotoxicity with or without hepatic impairment, gastrointestinal perforation, bullous and exfoliative skin disorders, myocardial infarction or ischemia, cerebrovascular accident, microangiopathic hemolytic anemia with thrombocytopenia, ocular disorders, and hemorrhage in patients taking warfarin.
Cautions & Contraindications
Warnings & Precautions
Interstitial lung disease (ILD) occurs in 1.1% of patients. Withhold Erloren if a patient develops an acute onset of new or worsening unexplained lung symptoms, such as breathlessness, cough or fever. Discontinue Erloren if ILD is diagnosed. Renal failure: monitor kidney function and electrolytes, particularly in patients at risk of dehydration. Withhold Erloren in cases of severe kidney toxicity. Hepatotoxicity, with or without existing liver impairment, including liver failure and hepatorenal syndrome: carry out periodic liver function tests. Withhold or discontinue Erloren if liver test results are severe or worsening. Gastrointestinal perforation: discontinue Erloren. Bullous and exfoliative skin disorders: discontinue Erloren. Myocardial infarction (MI) and ischaemia: the risk of MI is increased in patients with pancreatic cancer.
Pregnancy & Breastfeeding
Pregnancy category D. Erlotinib's mechanism of action suggests it can harm a developing fetus if taken during pregnancy. Whether Erlotinib passes into human breast milk is not known. Since many medicines do pass into breast milk, and because of the risk of serious side effects in a nursing infant, a decision should be made about whether to stop breastfeeding or stop the medicine, weighing how important it is for the mother's treatment.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric use: Safety and effectiveness of Erlotinib have not been established in pediatric patients.
Geriatric use: Subjects aged 65 years and older showed no overall differences in safety or efficacy compared with those younger than 65.
Overdose
Healthy volunteers have tolerated single oral doses of Erlotinib up to 1,000 mg, and cancer patients have tolerated weekly doses up to 1,600 mg. Things looked different with repeated dosing, though. When healthy subjects took 200 mg of Erlotinib alone twice daily, they tolerated it poorly after only a few days.
Going by these studies, doses above the recommended dose may cause an unacceptable number of severe adverse reactions, such as diarrhea, rash and raised liver transaminase levels. If an overdose is suspected, Erlotinib should be withheld and symptomatic treatment started.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Erlotinib in a dry place, at a temperature not above 30°C. Protect it from light and moisture.
Drug Interactions
Common questions about Ertinib 150 Tablet 150 mg
What is Ertinib 150 Tablet 150 mg Tablet?
Ertinib 150 Tablet 150 mg Tablet is a medicine that contains Erlotinib. It is made by Aristopharma Limited. It belongs to the Targeted Cancer Therapy group of medicines.
What is Ertinib 150 Tablet used for?
Ertinib 150 Tablet is used for: Cancer.
What are the side effects of Ertinib 150 Tablet?
The most common side effects of Erloren, seen in 20% or more of patients across a pooled analysis of studies, were rash, diarrhea, loss of appetite (anorexia), tiredness (fatigue), shortness of breath (dyspnea), cough, nausea, and vomiting. Serious side effects have also been reported, some of which may be fatal.
Can I take Ertinib 150 Tablet during pregnancy or while breastfeeding?
Pregnancy category D. Erlotinib's mechanism of action suggests it can harm a developing fetus if taken during pregnancy. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Ertinib 150 Tablet?
Healthy volunteers have tolerated single oral doses of Erlotinib up to 1,000 mg, and cancer patients have tolerated weekly doses up to 1,600 mg. Things looked different with repeated dosing, though. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Ertinib 150 Tablet?
Keep Erlotinib in a dry place, at a temperature not above 30°C. Protect it from light and moisture.
Can I take other medicines with Ertinib 150 Tablet?
Some medicines can interact with Erlotinib, for example: Calcium Citrate + Calcitriol, Ciprofloxacin, Rifampicin, Omeprazole, Ketoconazole, Ranitidine. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Ertinib 150 Tablet?
Ertinib 150 Tablet is a prescription (Rx) medicine. Take it as your doctor advises.