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Same active ingredient — pay up to 4% less
These brands contain the same active ingredient (Anastrozole). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Anastrozole is used as adjuvant treatment in postmenopausal women who have hormone receptor-positive early breast cancer. It is also used as first-line treatment in postmenopausal women with locally advanced or metastatic breast cancer, when the hormone receptors are positive or the receptor status is unknown. For advanced breast cancer in postmenopausal women whose disease has progressed after tamoxifen therapy, Anastrozole is used as second-line treatment. Patients with ER-negative disease, and those who did not respond to earlier tamoxifen therapy, rarely responded to Anastrozole.
Pharmacology
Anastrozole is a non-steroidal aromatase inhibitor. Many breast cancers grow because estrogens stimulate or maintain them. In postmenopausal women, most estrogen comes from the action of the aromatase enzyme, which converts adrenal androgens (mainly androstenedione and testosterone) to estrone and estradiol. So if the aromatase enzyme is specifically inhibited, estrogen production can be suppressed in peripheral tissues and in the cancer tissue itself.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual dose of Anastrozole is one 1 mg tablet taken once a day. In advanced breast cancer, the doctor should continue Anastrozole until the tumour progresses. For adjuvant treatment of early breast cancer in postmenopausal women, the best length of treatment isn't known.
Patients with hepatic impairment: No change in dose is recommended for mild to moderate hepatic impairment. Anastrozole has not been studied in patients with severe hepatic impairment.
Patients with renal impairment: No change in dose is needed.
Pediatric use: The safety and efficacy of Anastrozole in children have not been established.
Geriatric use: Age does not affect the pharmacokinetics of Anastrozole.
Side Effects
Serious side effects of Anastrozole, seen in less than 1 in 10,000 patients, are: 1) skin reactions such as lesions, ulcers or blisters; 2) allergic reactions with swelling of the face, lips, tongue and/or throat, which may make swallowing and/or breathing difficult; and 3) changes in liver function blood tests, including inflammation of the liver. The symptoms of this may include a general feeling of not being well, with or without jaundice, liver pain or liver swelling. Common side effects, occurring in more than 10% of women taking Anastrozole, included hot flashes, asthenia, arthritis, pain, arthralgia, hypertension, depression, nausea and vomiting, rash, osteoporosis, fractures, back pain, insomnia, pain, headache, bone pain, peripheral edema, increased cough, dyspnea, pharyngitis and lymphedema.
Cautions & Contraindications
Warnings & Precautions
Ischemic cardiovascular events In the ATAC trial, women with pre-existing ischemic heart disease had more ischemic cardiovascular events on Anastrozole than on tamoxifen. The rate was 17% of patients on Anastrozole and 10% of patients on tamoxifen. For patients who already have ischemic heart disease, the risks and benefits of Anastrozole treatment should be weighed. Bone effects The ATAC trial bone substudy looked at results at 12 and 24 months. Patients receiving Anastrozole had a mean decrease in both lumbar spine and total hip bone mineral density (BMD) compared to baseline. Patients receiving tamoxifen had a mean increase in both lumbar spine and total hip BMD compared to baseline. Cholesterol During the ATAC trial, more patients on Anastrozole were reported to have raised serum cholesterol than patients on tamoxifen (9% versus 3.5%, respectively).
Contraindications
Pregnancy and premenopausal women Anastrozole may cause harm to the baby when given to a pregnant woman. It also offers no clinical benefit to premenopausal women with breast cancer. So it is contraindicated in women who are pregnant or who may become pregnant. There are no adequate and well-controlled studies in pregnant women. If Anastrozole is used during pregnancy, or if the patient becomes pregnant while taking it, she should be told about the possible hazard to the baby and the possible risk of losing the pregnancy. Hypersensitivity Anastrozole is contraindicated in any patient who has shown a hypersensitivity reaction to the medicine or to any of its excipients.
Pregnancy & Breastfeeding
Anastrozole is Pregnancy Category X. Nobody knows whether Anastrozole passes into human breast milk. Many drugs do pass into milk, and they can cause serious side effects in a breastfed baby, so the mother and doctor need to decide whether to stop nursing or stop the medicine. That decision should take into account how much the mother needs the medicine.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Anastrozole has been given in clinical trials at up to 60 mg as a single dose to healthy male volunteers, and at up to 10 mg daily to postmenopausal women with advanced breast cancer. These doses were well tolerated. No single dose of Anastrozole that causes life-threatening symptoms has been established.
In rats, single oral doses greater than 100 mg/kg (about 800 times the recommended human dose on a mg/m2 basis) caused death. This was linked with severe irritation of the stomach, including necrosis, gastritis, ulceration and hemorrhage.
There is no specific antidote for an overdose, so treatment must be symptomatic.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Anastrozole below 30°C, away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Entroza 1 mg
What is Entroza 1 mg Tablet?
Entroza 1 mg Tablet is a medicine that contains Anastrozole. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Hormonal Chemotherapy group of medicines.
What is Entroza used for?
Anastrozole is used as adjuvant treatment in postmenopausal women who have hormone receptor-positive early breast cancer. It is also used as first-line treatment in postmenopausal women with locally advanced or metastatic breast cancer, when the hormone receptors are positive or the receptor status is unknown.
What are the side effects of Entroza?
Serious side effects of Anastrozole, seen in less than 1 in 10,000 patients, are: 1) skin reactions such as lesions, ulcers or blisters; 2) allergic reactions with swelling of the face, lips, tongue and/or throat, which may make swallowing and/or breathing difficult; and 3) changes in liver function blood tests, including inflammation of the liver. The symptoms of this may include a general feeling of not being well, with or without jaundice, liver pain or liver swelling.
Can I take Entroza during pregnancy or while breastfeeding?
Anastrozole is Pregnancy Category X. Nobody knows whether Anastrozole passes into human breast milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Entroza?
Anastrozole has been given in clinical trials at up to 60 mg as a single dose to healthy male volunteers, and at up to 10 mg daily to postmenopausal women with advanced breast cancer. These doses were well tolerated. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Entroza?
Store Anastrozole below 30°C, away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Entroza?
Some medicines can interact with Anastrozole, for example: Tamoxifen. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Anaya by Renata PLC has the same ingredient and strength for ৳48.00 per unit, compared with ৳50.00 for Entroza. Ask your doctor or pharmacist before switching.
Do I need a prescription for Entroza?
Entroza is a prescription (Rx) medicine. Take it as your doctor advises.