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Indications & Uses
Entafi is indicated for:
Pharmacology
Finasteride + Tadalafil combines two medicines: Finasteride, a specific inhibitor of steroid Type II 5a-reductase, and Tadalafil, a selective inhibitor of phosphodiesterase type-5 (PDE5). The 5a-reductase enzyme sits inside cells and converts the androgen testosterone into 5a-dihydrotestosterone (DHT). By blocking it, Finasteride lowers the level of DHT, the hormone that causes prostate growth, and as DHT falls the enlarged prostate gland in men shrinks. Tadalafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type-5 (PDE5). It may reduce Benign Prostatic Hyperplasia (BPH) symptoms by inhibiting the action of the enzyme PDE5 (phosphodiesterase 5), which relaxes the smooth muscles of the prostate that surround the urethra. This releases the restriction to the flow of urine through the urethra.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual adult dose of Finasteride + Tadalafil is one capsule by mouth once a day, at about the same time each day, for up to 26 weeks. It's best taken on an empty stomach. Don't use this combination for more than 26 weeks, because it isn't known whether it gives any extra benefit after that.
Pediatric use: the safety and effectiveness of Finasteride and Tadalafil haven't been established in patients under 18 years of age.
Geriatric use: no overall differences in safety or effectiveness of Finasteride and Tadalafil have been seen in patients aged 65 years and older.
Hepatic impairment: if liver function is moderately impaired, the medicine can be given with caution. If liver function is severely impaired, it isn't recommended.
Renal impairment: it isn't recommended for patients with creatinine clearance below 50 mL/min or for those on hemodialysis.
Side Effects
In a 4-year study, the most common side effects of finasteride on its own (seen in 1% or more of people) were impotence, decreased libido, a smaller volume of ejaculate and rash. With tadalafil, the most common side effects (seen in 2% or more) were headache, dyspepsia, back pain, myalgia, nasal congestion, flushing and pain in the limb.
Cautions & Contraindications
Warnings & Precautions
Finasteride + Tadalafil is not recommended for people who have had a myocardial infarction within the last 90 days, or who have unstable angina. It is also not recommended for people who were classified with heart failure in the last 6 months, or who have had a stroke within the last 6 months. The same applies to patients with uncontrolled arrhythmias, hypotension (<90/50 mm Hg) or uncontrolled hypertension. Hypersensitivity reactions: if any hypersensitivity reaction occurs, stop the medicine immediately. Prolonged erection: use Finasteride + Tadalafil with caution in patients who have an anatomical deformation of the penis. If an erection lasts more than 4 hours, the patient should seek emergency treatment.
Contraindications
Don't take this medicine with any form of organic nitrate, whether the nitrate is used regularly or only now and then. The combination can increase the blood pressure lowering effect of the nitrate.
Pregnancy & Breastfeeding
Finasteride + Tadalafil must not be used in pregnancy, and it isn't meant for use in females at all. If a pregnant woman touches a crushed or broken capsule, she should wash the area straight away with soap and water. The capsule is also not meant for use by breastfeeding mothers.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
If someone takes too much Finasteride + Tadalafil, the usual supportive measures should be given as needed.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Finasteride + Tadalafil in a dry place, and don't keep it above 30°C. Protect it from light. Keep it out of the reach of children.
Drug Interactions
Common questions about Entafi 5 mg+5 mg
What is Entafi 5 mg+5 mg Capsule?
Entafi 5 mg+5 mg Capsule is a medicine that contains Finasteride + Tadalafil. It is made by General Pharmaceuticals Ltd. It belongs to the BPH/ Urinary retention/ Urinary incontinence group of medicines.
What is Entafi used for?
Entafi is used for: Benign Prostatic Hyperplasia.
What are the side effects of Entafi?
In a 4-year study, the most common side effects of finasteride on its own (seen in 1% or more of people) were impotence, decreased libido, a smaller volume of ejaculate and rash. With tadalafil, the most common side effects (seen in 2% or more) were headache, dyspepsia, back pain, myalgia, nasal congestion, flushing and pain in the limb.
Can I take Entafi during pregnancy or while breastfeeding?
Finasteride + Tadalafil must not be used in pregnancy, and it isn't meant for use in females at all. If a pregnant woman touches a crushed or broken capsule, she should wash the area straight away with soap and water. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Entafi?
If someone takes too much Finasteride + Tadalafil, the usual supportive measures should be given as needed. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Entafi?
Store Finasteride + Tadalafil in a dry place, and don't keep it above 30°C. Protect it from light.
Can I take other medicines with Entafi?
Some medicines can interact with Finasteride + Tadalafil, for example: Tadalafil, Amlodipine, Metoprolol Tartrate, Enalapril Maleate. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Entafi is already among the lowest-priced brands of Finasteride + Tadalafil at this strength.
Do I need a prescription for Entafi?
Entafi is a prescription (Rx) medicine. Take it as your doctor advises.