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These brands contain the same active ingredient (Aprepitant). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Emend 125 mg is indicated for:
Pharmacology
Aprepitant is a selective, high affinity antagonist of human substance P neurokinin 1 (NK1) receptors. When substance P attaches to these receptors, it causes nausea and vomiting. Aprepitant stops substance P from binding to the NK1 receptors. By blocking the receptors, Aprepitant can prevent nausea and vomiting, which often happens after chemotherapy or as a complication of surgery.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Postoperative nausea and vomiting: the recommended oral dose of aprepitant is 40 mg, taken within 3 hours before induction of anaesthesia.
Chemotherapy-induced nausea and vomiting: for the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy, the following regimen should be used. On Day 1, aprepitant 125 mg orally, dexamethasone 12 mg orally, and a 5-HT3 antagonist (ondansetron) 24 mg given 30 minutes before the start of chemotherapy. On Day 2, aprepitant 80 mg orally and dexamethasone 8 mg orally. On Day 3, aprepitant 80 mg orally and dexamethasone 8 mg orally. On Day 4, dexamethasone 8 mg orally. Aprepitant is given orally 1 hour before chemotherapy on Day 1 and in the morning on Days 2 and 3. Dexamethasone is given 30 minutes before chemotherapy on Day 1 and in the morning on Days 2 through 4. The dexamethasone dose takes drug interactions into account.
For the prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy, the following regimen should be used. On Day 1, aprepitant 125 mg orally, dexamethasone 12 mg orally, and a 5-HT3 antagonist (ondansetron) as one 8 mg tablet 30 minutes before chemotherapy, followed by a further 8 mg dose 8 hours later. On Day 2, aprepitant 80 mg orally and ondansetron 8 mg tablet twice a day. On Day 3, aprepitant 80 mg orally and ondansetron 8 mg tablet twice a day. Aprepitant is given orally 1 hour before chemotherapy on Day 1 and in the morning on Days 2 and 3. Dexamethasone is given 30 minutes before chemotherapy on Day 1. The dexamethasone dose takes drug interactions into account.
Aprepitant may be taken with or without food. No dose adjustment is needed for elderly patients.
Side Effects
Aprepitant may cause constipation, hypotension, pruritus and pyrexia.
Cautions & Contraindications
Contraindications
Aprepitant must not be given to anyone who is hypersensitive to any ingredient in the product. It must also not be taken together with pimozide, terfenadine, astemizole or cisapride.
Pregnancy & Breastfeeding
Aprepitant is listed as Pregnancy Category B. Use it during pregnancy only when it is clearly needed. It is not known whether aprepitant passes into human milk. So if you are breastfeeding, you and your doctor will need to decide whether to stop nursing or stop the medicine, based on how important the medicine is for you.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Patients with renal impairment: you don't need to adjust the dose of Aprepitant for patients with renal impairment. The same applies to patients with end-stage renal disease (ESRD) who are on hemodialysis.
Patients with hepatic impairment: no dose adjustment is needed for patients with mild to moderate hepatic impairment. For patients with severe hepatic impairment, there are no clinical data.
Overdose
There is no specific information on how to treat an overdose of Aprepitant. In healthy volunteers, single doses of up to 600 mg were generally well tolerated. An overdose can cause drowsiness and headache. If someone takes too much, Aprepitant should be stopped, and general supportive treatment and monitoring should be given. Aprepitant has antiemetic activity, so trying to make the person vomit may not work. Hemodialysis cannot remove Aprepitant from the body.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Aprepitant below 30°C, away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Emend 125 mg 125 mg
What is Emend 125 mg 125 mg Capsule?
Emend 125 mg 125 mg Capsule is a medicine that contains Aprepitant. It is made by Opsonin Pharma Limited. It belongs to the Anti-emetic drugs group of medicines.
What is Emend 125 mg used for?
Emend 125 mg is used for: Nausea and Vomiting, Cancer.
What are the side effects of Emend 125 mg?
Aprepitant may cause constipation, hypotension, pruritus and pyrexia.
Can I take Emend 125 mg during pregnancy or while breastfeeding?
Aprepitant is listed as Pregnancy Category B. Use it during pregnancy only when it is clearly needed. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Emend 125 mg?
There is no specific information on how to treat an overdose of Aprepitant. In healthy volunteers, single doses of up to 600 mg were generally well tolerated. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Emend 125 mg?
Store Aprepitant below 30°C, away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Emend 125 mg?
Some medicines can interact with Aprepitant, for example: Olaparib, Fentanyl Citrate, Carbamazepine, Clarithromycin, Itraconazole, Nelfinavir. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Emend 125 mg?
Emend 125 mg is a prescription (Rx) medicine. Take it as your doctor advises.