Pricing
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All price changes →Elmood
Rx45 mg+105 mg • Tablet (Extended Release)
Indications & Uses
Elmood is indicated for:
Pharmacology
This is a combined medicine containing Dextromethorphan Hydrobromide and Bupropion Hydrochloride. Dextromethorphan is an uncompetitive antagonist of the NMDA receptor (an ionotropic glutamate receptor), and it also acts as a sigma-1 receptor agonist. How Dextromethorphan works in the treatment of MDD is unclear.
The way bupropion works in MDD is also unclear, though it may be related to noradrenergic and/or dopaminergic mechanisms. Bupropion raises the plasma levels of Dextromethorphan by competitively inhibiting cytochrome P450 2D6, an enzyme that catalyzes a major biotransformation pathway for Dextromethorphan. Bupropion is a relatively weak inhibitor of the neuronal reuptake of norepinephrine and dopamine. It does not inhibit monoamine oxidase or the reuptake of serotonin.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Start with one tablet of Dextromethorphan + Bupropion once daily in the morning. After 3 days, the dose goes up to the maximum recommended dosage, which is one tablet twice daily, with at least 8 hours between the two doses. Don't take more than two doses in one day.
Use in children and adolescents: the safety and effectiveness of this tablet have not been established. Antidepressants, including bupropion, increase the risk of suicidal thoughts and behaviors in pediatric patients.
Moderate renal impairment: one tablet by mouth once daily in the morning.
Side Effects
Side-effect information is not available for this brand yet.
Cautions & Contraindications
Warnings & Precautions
Seizure risk with Dextromethorphan + Bupropion is dose-related. If a seizure occurs, stop the medicine. Dextromethorphan + Bupropion can increase blood pressure and cause hypertension. Check the blood pressure before starting treatment, and keep monitoring it from time to time while the patient is on it. The medicine can also activate mania or hypomania, so patients should be screened for bipolar disorder. Psychosis and other neuropsychiatric reactions can occur as well. Tell patients to contact a doctor if they notice any such reaction.
Contraindications
Dextromethorphan + Bupropion must not be used by people with a seizure disorder. It is also not for anyone with a current or past diagnosis of bulimia or anorexia nervosa. Abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs is another contraindication. It must not be used with an MAOI, or within 14 days of stopping treatment with this combination. In the same way, don't use it within 14 days of discontinuing an MAOI. People with a known hypersensitivity should not take it either.
Pregnancy & Breastfeeding
There isn't enough clinical data on the use of dextromethorphan and bupropion together in pregnancy to judge the risk of major birth malformations, miscarriage, or other harmful outcomes for the mother or the baby. There is some data on one of the two components, bupropion. Epidemiological studies of pregnant women who took bupropion in the first trimester have not found an increased risk of congenital malformations overall. Untreated depression in pregnancy also carries risks for the mother.
Published literature reports that bupropion and its metabolites pass into human milk. No data are available on how bupropion or its metabolites affect milk production. A limited number of post-marketing reports describe bupropion use in breastfeeding women, and these have not identified a clear link with adverse reactions in the breastfed infant.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Very little clinical study experience exists on human overdose with Dextromethorphan + Bupropion, so the overdose information here comes from what is known about its two components, Dextromethorphan and Bupropion, taken separately. One point needs care. The Bupropion component inhibits the metabolism of the Dextromethorphan component, and because of this, an overdose of Dextromethorphan + Bupropion might be more severe or last longer than an overdose of dextromethorphan alone.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Dextromethorphan + Bupropion at or below 30˚C. Keep it away from light and from damp places, and don't store it anywhere wet. Keep it out of the reach of children.
Drug Interactions
Common questions about Elmood 45 mg+105 mg
What is Elmood 45 mg+105 mg Tablet (Extended Release)?
Elmood 45 mg+105 mg Tablet (Extended Release) is a medicine that contains Dextromethorphan + Bupropion. It is made by Eskayef Pharmaceuticals Ltd. It belongs to the Combined anxiolytics & anti-depressant drugs group of medicines.
What is Elmood used for?
Elmood is used for: Depression.
Can I take Elmood during pregnancy or while breastfeeding?
There isn't enough clinical data on the use of dextromethorphan and bupropion together in pregnancy to judge the risk of major birth malformations, miscarriage, or other harmful outcomes for the mother or the baby. There is some data on one of the two components, bupropion. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Elmood?
Very little clinical study experience exists on human overdose with Dextromethorphan + Bupropion, so the overdose information here comes from what is known about its two components, Dextromethorphan and Bupropion, taken separately. One point needs care. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Elmood?
Store Dextromethorphan + Bupropion at or below 30˚C. Keep it away from light and from damp places, and don't store it anywhere wet.
Can I take other medicines with Elmood?
Some medicines can interact with Dextromethorphan + Bupropion, for example: Digoxin. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Elmood is already among the lowest-priced brands of Dextromethorphan + Bupropion at this strength.
Do I need a prescription for Elmood?
Elmood is a prescription (Rx) medicine. Take it as your doctor advises.