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Same active ingredient — pay up to 40% less
These brands contain the same active ingredient (Furosemide + Spironolactone). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Edemide
Other strengths and forms by The ACME Laboratories Ltd.
Indications & Uses
Edemide is indicated for:
Pharmacology
Spironolactone is a potassium-sparing diuretic and Furosemide is a loop diuretic. They work in different ways and at different sites in the kidney, but the two actions complement each other, so together they give an additive or synergistic diuretic effect.
The Furosemide part blocks the Na+/K+/2Cl- co-transporter in the ascending Loop of Henle. This stops the reabsorption of sodium, potassium and chloride ions, so more sodium and a larger volume of water leave in the urine. Loss of potassium is a typical result of this action.
The spironolactone part acts at the distal tubule, where sodium is normally reabsorbed in exchange for potassium. It antagonises the action of aldosterone, which greatly favours sodium excretion and reduces the extra potassium loss caused by Furosemide.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Furosemide 20 mg with spironolactone 50 mg: the dose is 1 to 4 tablets daily, which gives 20 to 80 mg of furosemide and 50 to 200 mg of spironolactone. The exact number depends on how the patient responds.
Furosemide 40 mg with spironolactone 50 mg: this tablet is for patients who are already stabilized but need a higher dose of spironolactone and furosemide. It can be used at one to two tablets daily, which gives 40 to 80 mg of furosemide and 50 to 100 mg of spironolactone.
Use in children: furosemide and spironolactone is not suitable for children. In the elderly, both furosemide and spironolactone may be excreted more slowly.
Side Effects
Spironolactone can cause headache, drowsiness and stomach upset, including cramp and diarrhoea. Ataxia, mental confusion and skin rashes have also been reported as side effects. Gynaecomastia is not uncommon, and in rare cases the breast enlargement may persist. Other endocrine disorders can occur too, including hirsutism, deepening of the voice, menstrual irregularities and impotence. Blood-urea-nitrogen concentrations may rise for a short time, and mild acidosis has been reported. Spironolactone may also cause hyponatremia and hyperkalemia. Too much diuresis may lead to dehydration and a drop in blood volume, with circulatory collapse. There is also a possibility of vascular thrombosis and embolism, particularly in elderly patients. Serious depletion of potassium and magnesium may lead to cardiac arrhythmias.
Cautions & Contraindications
Warnings & Precautions
Take care with patients who are liable to electrolyte deficiency. Furosemide + Spironolactone should also be used with caution in people with diabetes, enlarged prostate, hypotension or hypovolemia.
Contraindications
Furosemide + Spironolactone should not be given to people who have anuria, acute renal insufficiency, or kidney function that is getting worse quickly or is severely impaired (creatinine clearance below 30 ml/min). It is also contraindicated in hyperkalaemia and Addison's disease. And anyone who is hypersensitive to Spironolactone, Furosemide or sulphonamides should not take it.
Pregnancy & Breastfeeding
Pregnancy: Spironolactone and its metabolites may cross the placental barrier. If a pregnant woman needs spironolactone, the doctor has to weigh the expected benefit against the possible harm to the mother and the fetus. Animal teratology studies show that Furosemide may cause fetal abnormalities. So Furosemide should be given to women of child bearing age only when suitable contraceptive measures are in place, or when the potential benefits justify the potential risks to the fetus.
Lactation: Metabolites of Spironolactone have been found in breast milk. If spironolactone is considered essential, the baby should be fed by another method instead. Furosemide is also excreted in breast milk, so breast-feeding should be stopped if treatment is essential.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Furosemide + Spironolactone below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Edemide 40 mg+50 mg
What is Edemide 40 mg+50 mg Tablet?
Edemide 40 mg+50 mg Tablet is a medicine that contains Furosemide + Spironolactone. It is made by The ACME Laboratories Ltd. It belongs to the Potassium-sparing diuretics group of medicines.
What is Edemide used for?
Edemide is used for: Hypertension, Heart Failure, Edema.
What are the side effects of Edemide?
Spironolactone can cause headache, drowsiness and stomach upset, including cramp and diarrhoea. Ataxia, mental confusion and skin rashes have also been reported as side effects.
Can I take Edemide during pregnancy or while breastfeeding?
Pregnancy: Spironolactone and its metabolites may cross the placental barrier. If a pregnant woman needs spironolactone, the doctor has to weigh the expected benefit against the possible harm to the mother and the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Edemide?
Store Furosemide + Spironolactone below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Edemide?
Some medicines can interact with Furosemide + Spironolactone, for example: Spironolactone, Indomethacin, Sucralfate, Digoxin, Furosemide. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Dilup by Advanced Chemical Industries PLC. has the same ingredient and strength for ৳6.00 per unit, compared with ৳10.03 for Edemide. Ask your doctor or pharmacist before switching.
Do I need a prescription for Edemide?
Edemide is a prescription (Rx) medicine. Take it as your doctor advises.