Pricing
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All price changes →Dyvon Plus
Rx0.05%+0.005% • Topical Suspension
More from Dyvon Plus
Other strengths and forms by Square Pharmaceuticals PLC, Pabna
Indications & Uses
Dyvon Plus is indicated for:
Pharmacology
Betamethasone Dipropionate is a potent, topically active corticosteroid that produces a prompt, marked and prolonged anti-inflammatory, antipruritic, vasoconstrictive and immunosuppressive effect, without curing the underlying condition. These effects can be enhanced under occlusive conditions, since occlusion increases penetration through the stratum corneum by roughly 10 times. Calcipotriol is a non-steroidal antipsoriatic agent derived from vitamin D. It exhibits a vitamin D-like effect by competing for the 1,25(OH)2D3 receptor. In regulating cell proliferation and differentiation, Calcipotriol is about as potent as 1,25(OH)2D3, the naturally occurring active form of vitamin D, but it is far less active than 1,25(OH)2D3 in its effect on calcium metabolism. Calcipotriol induces differentiation and suppresses proliferation of keratinocytes, with no evidence of a cytotoxic effect, thereby reversing the abnormal keratinocyte changes seen in psoriasis. The therapeutic goal of Calcipotriol treatment is thus to normalize epidermal growth.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
spray the required amount onto the affected areas once daily and gently rub in with the fingertips. Treatment may continue for up to 8 weeks and may be stopped earlier if symptoms clear. The weekly dose should not exceed 100 gm. Shake before use. This topical suspension is not meant for oral, ophthalmic, or intravaginal use.
Dosage for other forms (1)
This ointment is meant for topical use only. Its phototoxic effects have not been studied in people with psoriasis. Wherever possible, psoriasis-affected areas treated with this ointment should be protected from direct sunlight and UV light using clothing. Adults: apply the ointment to the affected area once daily. The daily dose should not exceed 15 gm, and the weekly dose should not exceed 100 gm. The treated area should cover no more than 30% of the body surface. Use should be intermittent, for up to one year, under close medical supervision. Treatment periods should be limited to four weeks, with Calcipotriol used alone for one month between periods of use of this ointment as needed. Children: this ointment is not recommended for children or adolescents under 18 years of age.
Side Effects
The most common side effects are folliculitis and a burning sensation of the skin.
Cautions & Contraindications
Warnings & Precautions
Hypercalcemia and hypercalciuria have been reported. If either occurs, treatment should be stopped until calcium metabolism returns to normal. Topical corticosteroids can cause reversible suppression of the hypothalamic pituitary adrenal (HPA) axis, Cushing's syndrome, and can unmask latent diabetes. The risk of adrenal suppression rises with longer treatment duration. If systemic absorption occurs, evaluation for HPA axis suppression may be needed, and use should be adjusted if suppression develops. Using potent corticosteroids, applying them over large areas, prolonged use, or occlusive use can all increase systemic absorption. Local adverse reactions may include skin atrophy, stretch marks, irritation, acne like eruptions, lightening of the skin, and allergic contact dermatitis; these are more likely with occlusive use or with more potent corticosteroids. This medicine is not recommended for use on the face, armpits, groin, or areas where skin atrophy is already present. Children may be more prone to systemic toxicity from topical corticosteroid treatment.
Contraindications
Betamethasone and Calcipotriol combination preparations should not be used in patients who are hypersensitive to any of their components. They are also unsuitable for patients with known disorders of calcium metabolism, and are contraindicated in those with severe kidney or liver impairment.
Pregnancy & Breastfeeding
There are no adequate, well-controlled studies looking at the use of this ointment or suspension in pregnant women. It should be used during pregnancy only if the expected benefit to the mother clearly outweighs any possible risk to the unborn baby. Corticosteroids taken systemically are known to pass into human breast milk, and in a nursing infant this can potentially slow growth, interfere with the baby's own natural corticosteroid production, or lead to other unwanted effects. It is not clear whether calcipotriol or betamethasone applied to the skin is absorbed into the body in amounts large enough to show up in breast milk. Since many medicines do pass into breast milk, this ointment or suspension should be used with caution in a breastfeeding mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store in a cool, dry place below 25ºC and protect from light. Don't refrigerate. Keep out of the reach of children.
Common questions about Dyvon Plus 0.05%+0.005%
What is Dyvon Plus 0.05%+0.005% Topical Suspension?
Dyvon Plus 0.05%+0.005% Topical Suspension is a medicine that contains Betamethasone + Calcipotriol. It is made by Square Pharmaceuticals PLC, Pabna. It belongs to the Betamethasone & Combined preparations group of medicines.
What is Dyvon Plus used for?
Dyvon Plus is used for: Psoriasis.
What are the side effects of Dyvon Plus?
The most common side effects are folliculitis and a burning sensation of the skin.
Can I take Dyvon Plus during pregnancy or while breastfeeding?
There are no adequate, well-controlled studies looking at the use of this ointment or suspension in pregnant women. It should be used during pregnancy only if the expected benefit to the mother clearly outweighs any possible risk to the unborn baby. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Dyvon Plus?
Store in a cool, dry place below 25ºC and protect from light. Don't refrigerate.
Do I need a prescription for Dyvon Plus?
Dyvon Plus is a prescription (Rx) medicine. Take it as your doctor advises.