Pricing
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Duxol is indicated for:
Pharmacology
Corticosteroids reduce the inflammatory response to a variety of triggering agents and may delay or slow healing. They limit swelling, fibrin deposition, capillary dilation, movement of white blood cells into tissue, capillary proliferation, fibroblast proliferation, collagen deposition, and scar formation associated with inflammation. There is no generally accepted explanation for how ocular corticosteroids work. However, they are thought to act by inducing phospholipase A2 inhibitory proteins, collectively known as lipocortins. These proteins are believed to control the production of potent inflammatory mediators such as prostaglandins and leukotrienes by blocking the release of their shared precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by the enzyme phospholipase A2. Difluprednate is structurally similar to other corticosteroids.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For inflammation and pain after eye surgery: put 1 drop into the conjunctival sac of the affected eye 4 times a day, starting 24 hours after surgery and continuing for the first 2 weeks after the operation. Then use 2 times a day for one week, and after that reduce the dose gradually depending on how the eye responds. For endogenous anterior uveitis: put 1 drop into the conjunctival sac of the affected eye 4 times a day for 14 days, then taper the dose as clinically indicated. For blepharitis: put 1 drop into the conjunctival sac of the affected eyes 2 times a day for 1 week, then once a day for 1 week. For pseudophakic cystoid macular oedema: put 1 drop into the conjunctival sac of the affected eyes 2 times a day.
Side Effects
Steroid eye drops, as a class, can cause a rise in pressure inside the eye, which may lead to damage to the optic nerve and loss of sharpness or areas of vision; clouding of the back of the lens (posterior subcapsular cataract); secondary eye infections caused by organisms such as herpes simplex; and, where the cornea or sclera is already thin, perforation of the eyeball. In patients treated with Predicot after eye surgery, the eye-related side effects reported included swelling of the cornea, redness of the ciliary body and conjunctiva, eye pain, sensitivity to light, clouding of the posterior lens capsule, cells and flare in the anterior chamber, swelling of the conjunctiva, and inflammation of the eyelids.
Cautions & Contraindications
Warnings & Precautions
Prolonged use of corticosteroids may lead to glaucoma and the formation of posterior subcapsular cataract. If Predicot is used for 10 days or longer, intraocular pressure (IOP) should be monitored. Great caution is required when corticosteroids are used to treat patients with a history of herpes simplex. Fungal infections of the cornea are particularly likely to develop alongside long-term local steroid use. Do not let the dropper tip touch any surface, as this may contaminate Predicot.
Contraindications
Difluprednate must not be used in most active viral infections of the cornea and conjunctiva, including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella. It is also contraindicated in mycobacterial infections of the eye and in fungal infections of the eye's structures.
Pregnancy & Breastfeeding
Pregnancy Category C. In animal studies, subcutaneous administration of Difluprednate to rabbits caused embryotoxic and teratogenic effects. Because its use during human pregnancy has not been studied, Difluprednate should be given to pregnant women only if the potential benefit outweighs the potential risk to the embryo or fetus. Whether Difluprednate passes into breast milk is not known, so caution is advised when it is used by nursing mothers.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric Use: Difluprednate was studied in children aged 0 to 3 years for inflammation after cataract surgery. Its safety profile in these children was similar to that of Prednisolone Acetate ophthalmic suspension 1%.
Geriatric Use: No overall differences in safety or effectiveness have been seen between elderly and younger patients taking Difluprednate.
Overdose
An overdose of Difluprednate does not usually cause acute problems. If the medicine is swallowed by accident, drink fluids to dilute it.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Difluprednate at room temperature, away from light, and don't let it freeze. Try not to use the contents more than 1 month after you first open the bottle.
Common questions about Duxol 0.05%
What is Duxol 0.05% Ophthalmic Emulsion?
Duxol 0.05% Ophthalmic Emulsion is a medicine that contains Difluprednate. It is made by OSL Pharma Ltd. It belongs to the Ophthalmic Steroid preparations group of medicines.
What is Duxol used for?
Duxol is used for: Pain, Edema, Inflammation.
What are the side effects of Duxol?
Steroid eye drops, as a class, can cause a rise in pressure inside the eye, which may lead to damage to the optic nerve and loss of sharpness or areas of vision; clouding of the back of the lens (posterior subcapsular cataract); secondary eye infections caused by organisms such as herpes simplex; and, where the cornea or sclera is already thin, perforation of the eyeball. In patients treated with Predicot after eye surgery, the eye-related side effects reported included swelling of the cornea, redness of the ciliary body and conjunctiva, eye pain, sensitivity to light, clouding of the posterior lens capsule, cells and flare in the anterior chamber, swelling of the conjunctiva, and inflammation of the eyelids.
Can I take Duxol during pregnancy or while breastfeeding?
Pregnancy Category C. In animal studies, subcutaneous administration of Difluprednate to rabbits caused embryotoxic and teratogenic effects. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Duxol?
An overdose of Difluprednate does not usually cause acute problems. If the medicine is swallowed by accident, drink fluids to dilute it. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Duxol?
Keep Difluprednate at room temperature, away from light, and don't let it freeze. Try not to use the contents more than 1 month after you first open the bottle.
Do I need a prescription for Duxol?
Duxol is a prescription (Rx) medicine. Take it as your doctor advises.