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Other brands with the same active ingredient
These brands contain the same active ingredient (Pidotimod). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Dotimod 400 Tablet is indicated for:
Pharmacology
Pidotimod strengthens and stimulates the immune mechanisms involved in humoral immunity, and also those of cellular immunity mediated by T lymphocytes. At the same time, it increases the migration of macrophages. This is an essential, primary step in the cellular immune response, because it allows adequate phagocytosis and elimination of the infectious germ. The medicine has an effective protective and preventive action against infections by Gram positive and Gram-negative germs. This action doesn't come from any antimicrobial property of its own but from its immunostimulant effect. It is absorbed rapidly after oral administration. For the tablet, the mean peak plasma concentration is reached 1.5 hours after a dose in adults, and oral bioavailability was 42 to 44%. Food doesn't change the extent of absorption, but it delays absorption and lowers bioavailability by up to 50%. So it is recommended to take Pidotimod two hours before or two hours after food. It is widely distributed throughout the body and is almost completely absorbed when given by mouth. Very little of it is metabolised in the liver, and no metabolites are known. Binding to plasma proteins is very poor, which is an advantage because it does not interfere with other medicines. The half-life is approximately 4 hours. Most of the medicine leaves the body in the urine, and a small amount in the feces.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
In the acute phase, adults take Pidotimod as 2 tablets of 400 mg or 1 tablet of 800 mg, twice a day. Take it two hours before or two hours after food, and continue for 15 days. The elderly and children take 1 tablet of 400 mg, twice a day, again two hours before or two hours after food and for 15 days. In the prophylactic phase, adults take 2 tablets of 400 mg or 1 tablet of 800 mg, once a day, two hours before or two hours after food, for 60 days. The elderly and children take 1 tablet of 400 mg, 1 time a day, two hours before or two hours after food and for 60 days. If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, skip the missed one. Don't double your dose to make up for it.
Side Effects
Pidotimod is generally well tolerated. Diarrhea may rarely occur in some patients. At high doses, and going by experience, sedation, ataxia, dyspnea and cyanosis may occur.
Cautions & Contraindications
Warnings & Precautions
Tell the doctor if the patient is allergic to Pidotimod or to any other medicine. Before starting Pidotimod, the doctor should also know if the patient has kidney disease or diabetes. Mention every other medicine being taken too, because many of them can make Pidotimod less effective or change how it works. The doctor also needs to know if the patient is pregnant or breastfeeding. Pidotimod should be taken with caution, especially in children below 12. In that case the doctor may adjust the dose depending on the child's age. Alcohol is not advisable with Pidotimod, as it may cause unpleasant side effects. Don't smoke either, because it can make the symptoms worse. Pidotimod does not cause any adverse effect of carcinogenesis. No mutagenic, teratogenic or fertility changes have been found either.
Contraindications
Pidotimod must not be given together with immunosuppressive treatment. It is also not for patients who are known to be hypersensitive to Pidotimod.
Pregnancy & Breastfeeding
There are no adequate and well-controlled studies of Pidotimod in pregnant women. It isn't recommended in the first trimester of pregnancy. Later in pregnancy, Pidotimod should be used only after weighing the risk against the benefit, and under medical supervision. It is not excreted in breast milk. Talk to your doctor before taking it.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric use: Pidotimod Tablet is not recommended for children less than 3 years. Before giving it to a child, consult a doctor, who will decide the dose on the basis of body mass, age and the condition of the infection.
Geriatric use: Pidotimod Tablet should be used with caution in elderly patients, especially those suffering from kidney diseases. Consult your doctor before using Pidotimod Tablet.
Overdose
There are no clinical data on overdose with doses higher than those recommended. The acute toxicity of Pidotimod is low, though. In such cases, slight sedation, ataxia, dyspnea and cyanosis occurred. These signs disappeared 24 hours after treatment was stopped and after gastric lavage, activated charcoal and supportive measures.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Pidotimod in a dry place below 30ºC, away from light. Keep it out of the reach of children.
Common questions about Dotimod 400 Tablet 400 mg
What is Dotimod 400 Tablet 400 mg Tablet?
Dotimod 400 Tablet 400 mg Tablet is a medicine that contains Pidotimod. It is made by Delta Pharma PLC. It belongs to the Cellular immunity mediated group of medicines.
What is Dotimod 400 Tablet used for?
Dotimod 400 Tablet is used for: Asthma, Chronic Obstructive Pulmonary Disease, Allergic Rhinitis, Pneumonia, Bronchitis, Sinusitis, Respiratory Tract Infection.
What are the side effects of Dotimod 400 Tablet?
Pidotimod is generally well tolerated. Diarrhea may rarely occur in some patients.
Can I take Dotimod 400 Tablet during pregnancy or while breastfeeding?
There are no adequate and well-controlled studies of Pidotimod in pregnant women. It isn't recommended in the first trimester of pregnancy. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Dotimod 400 Tablet?
There are no clinical data on overdose with doses higher than those recommended. The acute toxicity of Pidotimod is low, though. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Dotimod 400 Tablet?
Keep Pidotimod in a dry place below 30ºC, away from light. Keep it out of the reach of children.
Do I need a prescription for Dotimod 400 Tablet?
Dotimod 400 Tablet is a prescription (Rx) medicine. Take it as your doctor advises.