Indications & Uses
Dolaron Plus is indicated for:
Pharmacology
Paracetamol relieves pain and reduces fever, with only mild anti-inflammatory effect. It is thought to work mainly within the central nervous system (CNS), raising the pain threshold by inhibiting the COX-1, COX-2, and COX-3 enzyme isoforms involved in prostaglandin (PG) synthesis. Paracetamol, a para-aminophenol derivative also known as acetaminophen, is among the most widely used, safest, and fastest-acting pain relievers available, and it is well tolerated, avoiding the various side effects associated with aspirin.
Tramadol, for its part, is a centrally acting synthetic opioid painkiller. Its exact mode of action is not fully understood, but animal studies point to at least two complementary mechanisms: the binding of tramadol itself and its M1 metabolite to μ-opioid receptors, and a weak inhibition of norepinephrine and serotonin reuptake. Its opioid activity stems from both the low-affinity binding of the parent compound and the higher-affinity binding of the O-demethylated M1 metabolite to μ-opioid receptors. Tramadol has also been shown, in vitro, to inhibit reuptake of norepinephrine and serotonin, as do some other opioid analgesics. Together, these mechanisms are thought to contribute independently to tramadol's overall pain-relieving effect.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For the management of moderate to moderately severe pain: the recommended dose is 1 or 2 tablets every 4 to 6 hours as needed for pain relief, up to a maximum of 8 tablets per day. For short-term management (five days or less) of acute pain: the recommended dose is 2 tablets every 4 to 6 hours as needed for pain relief, up to a maximum of 8 tablets per day. This tablet can be taken without regard to food.
Side Effects
Some people may get side effects while taking this medicine. These can include weakness or tiredness, hot flushes, dizziness, headache, tremor, stomach pain, constipation, diarrhoea, indigestion, dry mouth, nausea, vomiting and loss of appetite. Some people also notice anxiety, confusion, a feeling of euphoria, trouble sleeping, nervousness or sleepiness. Itching, rash and increased sweating are also possible, and there may be others not listed here.
Cautions & Contraindications
Warnings & Precautions
Doloran Plus preparation may impair mental or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery. Doloran Plus preparation should not be taken with alcohol containing beverages. The patient should be instructed not to take Doloran Plus preparation in combination with other tramadol or paracetamol containing products, including over the counter preparations. Doloran Plus preparation should be used with caution when taking medications such as tranquilizers, hypnotics or other opiate containing analgesics.
Contraindications
Tramadol and Paracetamol combination tablets should not be given to patients who are known to be hypersensitive to tramadol, paracetamol, any other ingredient in the product, or opioids in general. They are also not to be used in any situation where opioid medicines are contraindicated.
Pregnancy & Breastfeeding
Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women, so this combination should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Paracetamol and tramadol hydrochloride together are not recommended for obstetrical preoperative medication, or for pain relief after delivery in nursing mothers, because their safety in infants and newborns has not been studied.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Paediatric use
The safety and effectiveness of Paracetamol + Tramadol Hydrochloride have not been studied in children.
Geriatric use
For an elderly patient, the dose should be chosen with care. Older people more often have reduced liver, kidney or heart function, and they more often have other diseases and take several medicines at once.
Use in renal disease
This medicine has not been studied in patients with impaired kidney function. If creatinine clearance is less than 30 ml/min, the dosing interval should be increased, but not beyond 2 tablets every 12 hours.
Use in hepatic disease
This medicine has not been studied in patients with impaired liver function either. It is not recommended for patients with hepatic impairment.
Storage
Keep this medicine in a cool, dry place and don't freeze it. Keep all medicines out of children's reach.
Common questions about Dolaron Plus 325 mg
What is Dolaron Plus 325 mg Tablet?
Dolaron Plus 325 mg Tablet is a medicine that contains Paracetamol + Tramadol Hydrochloride. It is made by One Pharma Ltd. It belongs to the Non-steroidal Anti-inflammatory Drugs (NSAIDs) group of medicines.
What is Dolaron Plus used for?
Dolaron Plus is used for: Pain.
What are the side effects of Dolaron Plus?
Some people may get side effects while taking this medicine. These can include weakness or tiredness, hot flushes, dizziness, headache, tremor, stomach pain, constipation, diarrhoea, indigestion, dry mouth, nausea, vomiting and loss of appetite.
Can I take Dolaron Plus during pregnancy or while breastfeeding?
Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women, so this combination should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Dolaron Plus?
Keep this medicine in a cool, dry place and don't freeze it. Keep all medicines out of children's reach.
Do I need a prescription for Dolaron Plus?
Dolaron Plus is a prescription (Rx) medicine. Take it as your doctor advises.