Indications & Uses
Santinal MR capsule is used for the secondary prevention of ischaemic stroke and transient ischaemic attacks, either on its own or together with aspirin. It is also used alongside oral anti-coagulant therapy to help prevent thromboembolism in patients with prosthetic heart valves.
Pharmacology
Dipyridamole is thought to work by inhibiting both adenosine deaminase and phosphodiesterase, which prevents the breakdown of cAMP, a substance that suppresses platelet function. As cAMP levels rise, the release of arachidonic acid from membrane phospholipids is blocked and thromboxane A2 activity is reduced. Dipyridamole also directly stimulates the release of prostacyclin, which activates adenylate cyclase, raising cAMP levels within platelets and further inhibiting platelet aggregation.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults, including the elderly: The recommended dose is one 200 mg capsule twice daily, usually one in the morning and one in the evening, preferably with meals. The capsules should be swallowed whole, without chewing.
Children: Dipyridamole 200 mg capsule is not recommended for children.
Side Effects
The following side effects have been reported with dipyridamole. Under blood and lymphatic system disorders, a drop in platelet count (thrombocytopenia) can occur. Under immune system disorders, people may have hypersensitivity reactions and angioedema. Nervous system disorders include headache and dizziness. Cardiac disorders include angina pectoris and tachycardia. Vascular disorders include hypotension and hot flush. Respiratory, thoracic and mediastinal disorders include bronchospasm, which is a tightening of the airways. Gastrointestinal disorders include diarrhoea, nausea and vomiting. Skin and subcutaneous tissue disorders include rash and urticaria. Musculoskeletal, connective tissue and bone disorders include myalgia, meaning muscle pain. Injury, poisoning and procedural complications include post procedural haemorrhage and operative haemorrhage, which are bleeding after a procedure and bleeding during an operation.
Cautions & Contraindications
Warnings & Precautions
Take care with dipyridamole in people whose angina is getting worse quickly, and in those with subvalvular aortic stenosis, haemodynamic instability linked to a recent MI, or coagulation disorders. This applies especially when it's given IV during myocardial imaging. Care is also needed in hypotension, unstable angina and aortic stenosis. Use in pregnancy and lactation needs the same caution. Safety and efficacy haven't been established in children under 12 years.
Contraindications
Hypersensitivity to any component of the product. Warnings and precautions: among other properties, dipyridamole acts as a potent vasodilator. It should therefore be used with caution in patients with severe coronary artery disease, including unstable angina and/or a recent heart attack, obstruction of the left ventricular outflow tract, or haemodynamic instability such as decompensated heart failure. Patients being treated with regular oral doses of Dipyridamole MR should not also be given intravenous dipyridamole. Clinical experience suggests that patients on oral dipyridamole who also need pharmacological stress testing with intravenous dipyridamole should stop oral dipyridamole containing medicines for twenty four hours before the test. In patients with myasthenia gravis, therapy may need to be readjusted after changes in dipyridamole dosage. Dipyridamole should be used with caution in patients with coagulation disorders.
Pregnancy & Breastfeeding
There isn't enough evidence to call dipyridamole fully safe in human pregnancy, but it has been used for many years without any apparent harm, and animal studies have shown no risk. Even so, medicines should generally be avoided in pregnancy, particularly during the first trimester, unless the expected benefit for the mother is thought to outweigh the possible risk to the unborn baby. Dipyridamole MR should be used during breastfeeding only if the physician considers it essential.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
There isn't much experience with Dipyridamole overdose, because only a small number of cases have been observed. Based on what is known, a person can be expected to feel warm, have flushes, sweat, and have a faster pulse. Restlessness, a feeling of weakness and dizziness may also occur, along with a drop in blood pressure and anginal complaints.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Dipyridamole below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Dipantin 100 mg
What is Dipantin 100 mg Tablet?
Dipantin 100 mg Tablet is a medicine that contains Dipyridamole. It is made by Square Pharmaceuticals PLC, Pabna. It belongs to the Anti-platelet drugs group of medicines.
What is Dipantin used for?
Santinal MR capsule is used for the secondary prevention of ischaemic stroke and transient ischaemic attacks, either on its own or together with aspirin. It is also used alongside oral anti-coagulant therapy to help prevent thromboembolism in patients with prosthetic heart valves.
What are the side effects of Dipantin?
The following side effects have been reported with dipyridamole. Under blood and lymphatic system disorders, a drop in platelet count (thrombocytopenia) can occur.
Can I take Dipantin during pregnancy or while breastfeeding?
There isn't enough evidence to call dipyridamole fully safe in human pregnancy, but it has been used for many years without any apparent harm, and animal studies have shown no risk. Even so, medicines should generally be avoided in pregnancy, particularly during the first trimester, unless the expected benefit for the mother is thought to outweigh the possible risk to the unborn baby. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Dipantin?
There isn't much experience with Dipyridamole overdose, because only a small number of cases have been observed. Based on what is known, a person can be expected to feel warm, have flushes, sweat, and have a faster pulse. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Dipantin?
Store Dipyridamole below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Dipantin?
Some medicines can interact with Dipyridamole, for example: Pentoxifylline, Benzoic Acid + Salicylic Acid, Heparin Sodium, Eptifibatide, Dalteparin Sodium, Fludarabine Phosphate. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Dipantin?
Dipantin is a prescription (Rx) medicine. Take it as your doctor advises.