Indications & Uses
Difix is indicated for:
Pharmacology
Diphenhydramine has anti-histaminic (H1-receptor), anti-emetic, anti-vertigo, sedative and hypnotic properties. Its anti-histamine action works by blocking the spasmogenic and congestive effects of histamine, competing with histamine for H1 receptor sites on effector cells and preventing (though not reversing) responses mediated by histamine alone. Such receptor sites may be found in the gut, uterus, large blood vessels, bronchial muscles, and elsewhere. Its anti-emetic action comes from inhibiting the medullary chemoreceptor trigger zone. Its anti-vertigo action comes from a central antimuscarinic effect on the vestibular apparatus and on the integrative vomiting center and medullary chemoreceptor trigger zone of the midbrain.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
As an antihistamine and antitussive, the tablet dose for adults is 25 mg to 50 mg taken 3 to 4 times daily, while children aged 10 years or over take 25 mg 3 or 4 times daily or as directed by the physician. For the syrup, children under 2 years take 2.5 mL every 4 to 6 hours, children aged 2 to under 6 years take 5 mL every 4 to 6 hours, children aged 6 to 12 years take 10-20 mL every 4 to 6 hours, and adults and children aged 12 years or over take 10-20 mL every 4 to 6 hours. As a sleep aid, adults and children over 12 years take 50 mg at bedtime.
Side Effects
Common side effects include drowsiness, dizziness, dry mouth, nausea and vomiting. Less commonly reported effects are vertigo, palpitations, blurred vision, headache, restlessness, insomnia and thickening of bronchial secretions. Allergic reactions, diarrhoea, vomiting and excitation may also occur.
Cautions & Contraindications
Warnings & Precautions
Do not drive a vehicle or operate hazardous machinery until you know how this medicine affects you.
Contraindications
Diphenhydramine is contraindicated in premature or newborn infants and in anyone hypersensitive to any component of this drug. It should also not be used during an asthma attack or in patients with narrow-angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, or bladder neck obstruction, or in patients receiving antidepressant therapy.
Pregnancy & Breastfeeding
Safety in pregnancy and breastfeeding has not been firmly established. If use is being considered during these periods, the potential benefits should be weighed carefully against any possible risks.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
If someone takes too much diphenhydramine hydrochloride, the effect on the central nervous system can go either way. It may be depressed (slowed down) or it may be stimulated. Stimulation is particularly likely in children.
Atropine-like signs and symptoms can also appear. These include dryness of the mouth, fixed and dilated pupils, flushing and gastrointestinal symptoms.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Diphenhydramine Hydrochloride below 30°C. Keep it away from light and from damp places. Keep it out of reach of children.
Drug Interactions
Common questions about Difix 10 mg
What is Difix 10 mg Syrup?
Difix 10 mg Syrup is a medicine that contains Diphenhydramine Hydrochloride. It is made by Medicon Pharmaceuticals Ltd. It belongs to the Sedating Anti-histamine group of medicines.
What is Difix used for?
Difix is used for: Allergic Rhinitis, Fever, Parkinson's Disease, Nausea and Vomiting, Eczema, Urticaria, Insomnia, Allergy, Conjunctivitis.
What are the side effects of Difix?
Common side effects include drowsiness, dizziness, dry mouth, nausea and vomiting. Less commonly reported effects are vertigo, palpitations, blurred vision, headache, restlessness, insomnia and thickening of bronchial secretions.
Can I take Difix during pregnancy or while breastfeeding?
Safety in pregnancy and breastfeeding has not been firmly established. If use is being considered during these periods, the potential benefits should be weighed carefully against any possible risks. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Difix?
If someone takes too much diphenhydramine hydrochloride, the effect on the central nervous system can go either way. It may be depressed (slowed down) or it may be stimulated. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Difix?
Store Diphenhydramine Hydrochloride below 30°C. Keep it away from light and from damp places.
Can I take other medicines with Difix?
Some medicines can interact with Diphenhydramine Hydrochloride, for example: Polymyxin B Sulfate, Guaifenesin + Levomenthol + Diphenhydramine, Diphenhydramine + Dextromethorphan + Levomenthol, Guaifenesin + Dextromethorphan + Menthol, Dextromethorphan + Phenylephrine + Triprolidine, Adrenaline. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Difix?
Difix is a prescription (Rx) medicine. Take it as your doctor advises.