Pricing
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Indications & Uses
Dieta Plus is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The starting dose of Pioglitazone and Glimepiride depends on what the patient is already taking, Pioglitazone, a sulfonylurea, or both. Patients who may be more sensitive to antihyperglycemic drugs should be monitored carefully while the dose is being adjusted. A single dose of Pioglitazone and Glimepiride is recommended once daily with the first main meal.
For patients currently on Glimepiride alone, the usual starting dose of Pioglitazone (15 mg or 30 mg daily) is the guide. The combination may be started at 30 mg/2 mg or 30 mg/4 mg tablet strength once daily, then adjusted after checking whether the therapeutic response is adequate.
For patients currently on Pioglitazone alone, the guide is the usual starting dose of Glimepiride (1 mg or 2 mg once daily) along with Pioglitazone 15 mg or 30 mg. The combination may be started at 30 mg/2 mg once daily, then adjusted after checking whether the therapeutic response is adequate.
For patients switching from Pioglitazone plus Glimepiride taken as separate tablets, the combination may be started at 30 mg/2 mg or 30 mg/4 mg, depending on the doses of Pioglitazone and Glimepiride they already take. Patients who are not controlled on 15 mg of Pioglitazone with Glimepiride should be monitored carefully when they move to the combination.
For patients currently on a different sulfonylurea alone, or switching from Pioglitazone plus a different sulfonylurea, there is no exact dose relationship between Glimepiride and the other sulfonylurea agents. So the starting dose should be limited to 30 mg/2 mg once daily, based on the maximum starting dose of 2 mg Glimepiride. It is then adjusted after checking whether the therapeutic response is adequate.
Side Effects
Pioglitazone: In studies of Pioglitazone on its own, the most common side effects (reported by 5% or more of patients) were upper respiratory tract infection, injury and headache. When Pioglitazone was given with a sulfonylurea, the side effects reported were similar to those seen with Pioglitazone alone. In controlled clinical studies, other events reached at least 5% of patients on Pioglitazone alone. These were myalgia (2.7% with placebo and 5.4% with Pioglitazone), tooth disorder (2.3% and 5.3%), diabetes mellitus aggravated (8.1% and 5.1%) and pharyngitis (0.8% and 5.1%). In the same monotherapy studies, edema was reported in 4.8% of patients treated with Pioglitazone (at doses from 7.5 mg to 45 mg), compared with 1.2% of patients given placebo. Glimepiride: Hypoglycemia: The incidence of hypoglycemia with Glimepiride is documented. Apart from hypoglycemia, the events thought to be possibly or probably related to the study drug in more than 1% of patients treated with Glimepiride were dizziness (1.7%), asthenia (1.6%), headache (1.5%) and nausea (1.1%). Dermatologic Reactions: Allergic skin reactions, such as pruritus, erythema, urticaria, and morbilliform or maculopapular eruptions, occur in less than 1% of treated patients. These reactions may be transient, and they may go away even if Glimepiride is continued.
Cautions & Contraindications
Warnings & Precautions
General Because of how it works, Pioglitazone is active only when the body has some insulin of its own. So the Pioglitazone and Glimepiride combination should not be used in people with type 1 diabetes, or to treat diabetic ketoacidosis. Hypoglycemia All sulfonylurea drugs can cause severe hypoglycemia. Choosing the right patient, the right dose and giving proper instructions are important to avoid hypoglycemic episodes. Elderly patients are particularly susceptible to the hypoglycemic action of glucose lowering drugs. The same is true of debilitated or malnourished patients, and those with adrenal, pituitary, renal or hepatic insufficiency. Loss of Control of Blood Glucose A patient may be stable on an antidiabetic regimen and then meet stress such as fever, trauma, infection or surgery. Glycemic control can be lost for a time when this happens. In that situation it may be necessary to withhold the combination and give insulin for a while. The combination may be started again once the acute episode is over. Edema Use the combination with caution in patients with edema. Thiazolidinediones, including Pioglitazone, can cause fluid retention, and this can worsen or lead to congestive heart failure. So the combination should also be used with caution in patients at risk for heart failure. Weight Gain Weight gain that depended on the dose was seen with Pioglitazone alone and with Pioglitazone combined with other hypoglycemic agents. The mechanism is unclear, but it probably involves fluid retention and fat accumulation together. Hepatic Effects Liver enzymes should be checked in all patients before starting the combination, and then from time to time, as the healthcare professional judges best. Therapy should not be started in patients whose baseline liver enzyme levels are already raised (ALT >2.5X upper limit of normal). If ALT rises to >3X the upper limit of normal at any point during therapy, the liver enzymes should be rechecked as soon as possible. If ALT stays above 3X the upper limit of normal, the combination should be stopped. Liver enzymes should also be checked if a patient develops symptoms suggesting hepatic dysfunction. These may include unexplained nausea, vomiting, abdominal pain, fatigue and anorexia, and/or dark urine.
Contraindications
Pioglitazone and Glimepiride combination should not be given to people who have a known hypersensitivity to Pioglitazone or Glimepiride, or to any other component of the combination. It is also contraindicated in diabetic ketoacidosis, with or without coma. That condition should be treated with insulin.
Pregnancy & Breastfeeding
Pioglitazone + Glimepiride is in pregnancy category C. Current information strongly suggests that abnormal blood glucose levels during pregnancy are linked to a higher rate of congenital anomalies and more illness and death in newborns. Because of this, most experts recommend insulin alone during pregnancy, so that blood glucose stays as close to normal as possible. The combination of Pioglitazone and Glimepiride should not be used during pregnancy.
Nursing mothers: No studies have been done with the combination of Pioglitazone and Glimepiride. It is not known whether Pioglitazone and/or Glimepiride pass into human milk. Many drugs do pass into human milk, so the combination should not be given to a breastfeeding woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric use
Safety and effectiveness of the Pioglitazone and Glimepiride combination in children have not been established.
Geriatric use
For Pioglitazone, a population pharmacokinetic analysis showed that age does not significantly affect how the body handles the drug. So no dose adjustment is needed for elderly patients.
Glimepiride is known to be excreted largely by the kidney, and the risk of toxic reactions to Pioglitazone + Glimepiride may be greater in people with impaired renal function. Elderly patients are more likely to have reduced renal function, so take care when choosing the dose. It may also be useful to monitor renal function.
Overdose
An overdose of Pioglitazone + Glimepiride can cause severe hypoglycaemia, with coma, seizure or neurological impairment. For treatment, give glucagon or IV glucose. The person may also need extra carbohydrate, because hypoglycaemia can come back even after they seem to have recovered.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Pioglitazone + Glimepiride in a cool, dry place and away from light and moisture. Always keep it out of the reach of children.
Drug Interactions
Common questions about Dieta Plus 30 mg+2 mg
What is Dieta Plus 30 mg+2 mg Tablet?
Dieta Plus 30 mg+2 mg Tablet is a medicine that contains Pioglitazone + Glimepiride. It is made by Pacific Pharmaceuticals Ltd. It belongs to the Combination Oral hypoglycemic preparations group of medicines.
What is Dieta Plus used for?
Dieta Plus is used for: Type 2 Diabetes Mellitus, Diabetes Mellitus.
What are the side effects of Dieta Plus?
Pioglitazone: In studies of Pioglitazone on its own, the most common side effects (reported by 5% or more of patients) were upper respiratory tract infection, injury and headache. When Pioglitazone was given with a sulfonylurea, the side effects reported were similar to those seen with Pioglitazone alone.
Can I take Dieta Plus during pregnancy or while breastfeeding?
Pioglitazone + Glimepiride is in pregnancy category C. Current information strongly suggests that abnormal blood glucose levels during pregnancy are linked to a higher rate of congenital anomalies and more illness and death in newborns. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Dieta Plus?
An overdose of Pioglitazone + Glimepiride can cause severe hypoglycaemia, with coma, seizure or neurological impairment. For treatment, give glucagon or IV glucose. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Dieta Plus?
Keep Pioglitazone + Glimepiride in a cool, dry place and away from light and moisture. Always keep it out of the reach of children.
Can I take other medicines with Dieta Plus?
Some medicines can interact with Pioglitazone + Glimepiride, for example: Miconazole, Pioglitazone, Isoniazid, Ibuprofen, Naproxen, Glimepiride. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Dieta Plus is already among the lowest-priced brands of Pioglitazone + Glimepiride at this strength.
Do I need a prescription for Dieta Plus?
Dieta Plus is a prescription (Rx) medicine. Take it as your doctor advises.