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Indications & Uses
Lamivudine and zidovudine tablets combine 2 nucleoside analogue reverse transcriptase inhibitors in one tablet. They are used for HIV-1 infection, always together with other antiretroviral medicines and never on their own.
Pharmacology
Lamivudine and Zidovudine are synthetic nucleoside analogues that work against the human immunodeficiency virus (HIV).
Lamivudine: Inside the cell, Lamivudine is converted into its active form, 5'-triphosphate, called Lamivudine triphosphate (L-TP). L-TP works mainly by blocking reverse transcription (RT). It does this by ending the growing DNA chain once the nucleoside analogue has been built into it. After it is taken by mouth, Lamivudine is absorbed quickly and spreads widely through the body. Very little of it binds to plasma protein.
Zidovudine: Inside the cell, Zidovudine is also converted into its active 5'-triphosphate form, Zidovudine triphosphate (ZDV-TP). Like Lamivudine, ZDV-TP works mainly by blocking reverse transcription (RT), stopping the DNA chain from growing once the nucleoside analogue is incorporated. Zidovudine is absorbed quickly after it is taken by mouth and spreads widely through the body, and only a small amount binds to plasma protein. Most of it is broken down and cleared by the liver.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Recommended dosage for adults and adolescents: In HIV-1-infected adults and adolescents weighing 30 kg or more, the usual dose is 1 tablet (containing 150 mg lamivudine and 300 mg zidovudine) taken by mouth twice daily. Recommended dosage for pediatric patients: For children weighing 30 kg or more who are able to take a solid oral dosage form, the usual dose is also 1 tablet taken by mouth twice daily on an empty stomach. Before this medicine is prescribed, the child's ability to swallow tablets should be assessed; if a child cannot reliably swallow a tablet, a liquid oral formulation should be used instead. Not recommended due to lack of dosage adjustment: because this is a fixed-dose combination tablet that cannot be adjusted, it is not recommended for pediatric patients weighing less than 30 kg, patients with creatinine clearance below 50 mL per minute, patients with hepatic impairment, or patients experiencing dose-limiting adverse reactions. For these groups, the individual components are available separately in liquid and solid oral formulations.
Side Effects
Side effects of this medicine More common: chills, fever, pale skin, sore throat, unusual tiredness or weakness, and headache. Less common: abdominal pain; a burning, tingling, or numb sensation or pain in the hands, arms, feet, or legs; muscle tenderness and weakness; nausea; skin rash; vomiting; and yellowing of the eyes or skin. Coughing, reduced appetite, diarrhea, dizziness, and trouble sleeping may also occur.
Cautions & Contraindications
Warnings & Precautions
Patients with HIV and Hepatitis B virus coinfection The safety and efficacy of Lamivudine have not been established for treating chronic hepatitis B in patients who have both HIV and HBV. In HIV-infected patients who also have hepatitis B and have received antiretroviral regimens containing Lamivudine, hepatitis B virus variants resistant to Lamivudine have been reported. Hepatitis has also been reported to flare up after treatment is stopped. Patients with impaired renal function Lower doses of Lamivudine and Zidovudine are recommended for patients with impaired renal function. Patients whose creatinine clearance is below 50 ml/min should not take Avudin tablet. Fat redistribution Patients on antiretroviral therapy have shown redistribution or build-up of body fat. This includes central obesity, enlargement of fat at the back of the neck and shoulders (buffalo hump), wasting of the limbs and face, breast enlargement, and a cushingoid appearance.
Contraindications
Contraindicated in patients with a known history of clinically significant hypersensitivity to any of its ingredients. Because Lamivudine doses need to be reduced in patients weighing less than 50 kg (110 lb), the fixed-dose Lamivudine & Zidovudine combination is not suitable for use in low-body-weight patients.
Pregnancy & Breastfeeding
Lamivudine + Zidovudine falls under Pregnancy Category C. There are no adequate and well controlled studies of this drug in pregnant women, so it should be used during pregnancy only if the potential benefits outweigh the risks.
The Centers for Disease Control and Prevention recommend that mothers with HIV should not breast-feed their infants, to avoid the risk of passing HIV on after birth. HIV can be transmitted through breast milk, and nursing infants may also suffer serious adverse effects. For these reasons mothers should be told not to breast-feed if they are receiving efavirenz.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Lamivudine + Zidovudine in a cool, dry place, away from light and moisture. Make sure children can't reach the medicine.
Drug Interactions
Common questions about Diavix 150 mg+300 mg
What is Diavix 150 mg+300 mg Tablet?
Diavix 150 mg+300 mg Tablet is a medicine that contains Lamivudine + Zidovudine. It is made by Beximco Pharmaceuticals Ltd. It belongs to the Drugs for HIV / Anti-retroviral drugs group of medicines.
What is Diavix used for?
Lamivudine and zidovudine tablets combine 2 nucleoside analogue reverse transcriptase inhibitors in one tablet. They are used for HIV-1 infection, always together with other antiretroviral medicines and never on their own.
What are the side effects of Diavix?
Side effects of this medicine More common: chills, fever, pale skin, sore throat, unusual tiredness or weakness, and headache. Less common: abdominal pain; a burning, tingling, or numb sensation or pain in the hands, arms, feet, or legs; muscle tenderness and weakness; nausea; skin rash; vomiting; and yellowing of the eyes or skin.
Can I take Diavix during pregnancy or while breastfeeding?
Lamivudine + Zidovudine falls under Pregnancy Category C. There are no adequate and well controlled studies of this drug in pregnant women, so it should be used during pregnancy only if the potential benefits outweigh the risks. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Diavix?
Keep Lamivudine + Zidovudine in a cool, dry place, away from light and moisture. Make sure children can't reach the medicine.
Can I take other medicines with Diavix?
Some medicines can interact with Lamivudine + Zidovudine, for example: Zidovudine, Pyrimethamine, Ganciclovir, Ribavirin, Lamivudine, Dapsone. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Diavix is already among the lowest-priced brands of Lamivudine + Zidovudine at this strength.
Do I need a prescription for Diavix?
Diavix is a prescription (Rx) medicine. Take it as your doctor advises.