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Same active ingredient — pay up to 90% less
These brands contain the same active ingredient (Triamterene + Hydrochlorothiazide). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Dezide is indicated for:
Pharmacology
Triamterene works directly on the distal renal tubule, where it blocks the exchange of Na for K and hydrogen. Hydrochlorothiazide cuts the reabsorption of electrolytes from the renal tubules, so more Na and Cl ions are passed out in the urine, and water goes with them.
Hydrochlorothiazide is a thiazide diuretic. Thiazides act on the tubular mechanisms that reabsorb electrolytes, and they directly raise the excretion of sodium and chloride in approximately equivalent amounts. The diuretic action also has indirect effects. Plasma volume falls, and this brings increased plasma renin activity, increased aldosterone secretion, greater potassium loss in the urine and a drop in serum potassium. Angiotensin II mediates the renin-aldosterone link, so giving an angiotensin converting enzyme (ACE) inhibitor together with these diuretics tends to reverse the potassium loss.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual dose of triamterene with hydrochlorothiazide is one or two capsules once daily, with serum potassium and the clinical effect checked as needed.
Side Effects
Hypersensitivity reactions include anaphylaxis, rash, urticaria, subacute cutaneous lupus erythematosus-like reactions and photosensitivity. Cardiovascular effects are arrhythmia and postural hypotension. Metabolic effects include diabetes mellitus, hyperkalemia, hypokalemia, hyponatremia, acidosis, hypercalcemia, hyperglycemia, glycosuria, hyperuricemia and hypochloremia. Gastrointestinal effects are jaundice and/or liver enzyme abnormalities, pancreatitis, nausea and vomiting, diarrhea, constipation and abdominal pain. Renal effects include acute renal failure (one case of irreversible renal failure has been reported), interstitial nephritis, renal stones composed primarily of triamterene, elevated BUN and serum creatinine, and abnormal urinary sediment. Hematologic effects are leukopenia, thrombocytopenia and purpura, and megaloblastic anemia. Musculoskeletal: muscle cramps. Central nervous system effects include weakness, fatigue, dizziness, headache and dry mouth. Miscellaneous effects are impotence and sialadenitis. Further central nervous system effects are paresthesias and vertigo. Ophthalmic effects are xanthopsia and transient blurred vision. Respiratory effects include allergic pneumonitis, pulmonary edema and respiratory distress.
Cautions & Contraindications
Warnings & Precautions
Take care when giving Dyazide (triamterene with hydrochlorothiazide) to patients with diabetes. Thiazides may cause hyperglycemia and glycosuria, and they can change insulin requirements in diabetes. Diabetes mellitus may also become manifest while a patient is taking a thiazide. In impaired hepatic function, thiazides should be used with caution, because they can precipitate hepatic coma in patients with severe liver disease. Potassium depletion caused by the thiazide may be important here. Give Dyazide cautiously and watch for early signs of impending coma such as confusion, drowsiness and tremor. If mental confusion increases, stop Dyazide for a few days. Other factors that may precipitate hepatic coma also need attention, such as blood in the gastrointestinal tract or preexisting potassium depletion. Hypokalemia is uncommon with Dyazide, but if it develops, corrective measures should be taken, such as potassium supplementation or eating more potassium-rich foods. Start these measures carefully and check serum potassium levels often, especially in patients receiving digitalis or with a history of cardiac arrhythmias. If repeat serum potassium tests show serious hypokalemia (serum potassium less than 3.0 mEq/L), stop Dyazide and start potassium chloride supplementation. Less serious hypokalemia should be judged in light of other coexisting conditions and treated accordingly. Electrolyte imbalance is often seen in conditions such as heart failure, renal disease or cirrhosis of the liver, and diuretics may make it worse. Keep this in mind during Dyazide therapy when high doses are used for a long time, or when the patient is on a salt-restricted diet. Serum electrolytes should be checked, and this matters even more if the patient is vomiting excessively or receiving fluids parenterally. Warning signs of a possible fluid and electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, hypotension, oliguria, tachycardia and gastrointestinal symptoms.
Contraindications
Antikaliuretic Therapy and Potassium Supplementation Dyazide should not be given to patients who are already taking other potassium-sparing agents such as spironolactone, amiloride, or other formulations containing triamterene. Potassium-containing salt substitutes should not be used either. Potassium supplementation should not be used with Dyazide except in severe cases of hypokalemia, because this combination can cause a rapid rise in serum potassium levels. If potassium supplementation is used, the serum potassium level needs careful monitoring. Impaired Renal Function Dyazide is contraindicated in patients with anuria, acute and chronic renal insufficiency or significant renal impairment. Hypersensitivity Hypersensitivity to either drug in the preparation, or to other sulfonamide-derived drugs, is a contraindication. Hyperkalemia Dyazide should not be used in patients who already have an elevated serum potassium level.
Pregnancy & Breastfeeding
Giving diuretics such as Triamterene + Hydrochlorothiazide to an otherwise healthy pregnant woman as a routine is not appropriate. It puts both the mother and the baby at risk for no good reason. Diuretics don't prevent toxemia of pregnancy, and there is no satisfactory evidence that they help once toxemia has developed.
Swelling (edema) in pregnancy can come from a disease process, or it can be a normal result of the body changes and the physical pressure of pregnancy. When the swelling is due to a pathological cause, diuretics are indicated in pregnancy, just as they would be in a woman who is not pregnant.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Triamterene + Hydrochlorothiazide at controlled room temperature, between 20° and 25°C. Brief periods between 15° and 30°C are acceptable. Protect it from light. When dispensing, use a tight, light-resistant container.
Drug Interactions
Common questions about Dezide 50 mg+25 mg
What is Dezide 50 mg+25 mg Tablet?
Dezide 50 mg+25 mg Tablet is a medicine that contains Triamterene + Hydrochlorothiazide. It is made by Eskayef Pharmaceuticals Ltd. It belongs to the Combined antihypertensive preparations group of medicines.
What is Dezide used for?
Dezide is used for: Hypertension, Edema.
What are the side effects of Dezide?
Hypersensitivity reactions include anaphylaxis, rash, urticaria, subacute cutaneous lupus erythematosus-like reactions and photosensitivity. Cardiovascular effects are arrhythmia and postural hypotension.
Can I take Dezide during pregnancy or while breastfeeding?
Giving diuretics such as Triamterene + Hydrochlorothiazide to an otherwise healthy pregnant woman as a routine is not appropriate. It puts both the mother and the baby at risk for no good reason. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Dezide?
Keep Triamterene + Hydrochlorothiazide at controlled room temperature, between 20° and 25°C. Brief periods between 15° and 30°C are acceptable.
Can I take other medicines with Dezide?
Some medicines can interact with Triamterene + Hydrochlorothiazide, for example: Baclofen, Tacrolimus, Cisplatin, Tizanidine, Noradrenaline. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
G-Thiazide T by Gonoshasthaya Pharmaceuticals Ltd. has the same ingredient and strength for ৳0.50 per unit, compared with ৳5.00 for Dezide. Ask your doctor or pharmacist before switching.
Do I need a prescription for Dezide?
Dezide is a prescription (Rx) medicine. Take it as your doctor advises.