More from Darifen
Other strengths and forms by The ACME Laboratories Ltd.
Indications & Uses
Darifen ER is used to treat overactive bladder, helping relieve symptoms such as urgent, frequent, and sometimes uncontrollable urges to urinate.
Pharmacology
Darifenacin is a potent, competitive muscarinic receptor antagonist that binds preferentially to the M3 subtype. M3 receptors govern contraction of the bladder's detrusor muscle, along with GI smooth muscle activity, saliva production, and iris sphincter function. By acting on these receptors, darifenacin can raise the volume threshold that triggers involuntary detrusor contractions, thereby increasing the bladder's effective capacity.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Darifenacin 7.5 mg once daily; the dose may be increased to 15 mg once daily if the response is not adequate after 2 weeks of therapy. Darifenacin should be taken with liquid. It can be taken with or without food, and should be swallowed whole rather than chewed, divided or crushed. For patients with moderate hepatic impairment, or when co-administered with potent CYP3A4 inhibitors such as ketoconazole, itraconazole, ritonavir, nelfinavir, clarithromycin and nefazodone, the daily dose of Darifenacin should not exceed 7.5 mg.
Side Effects
Dry mouth and constipation are the most common side effects experienced with this medicine. Other, less frequent side effects that have been reported include blurred or abnormal vision, back pain, dry skin, raised blood pressure, vomiting, swelling of the extremities (peripheral edema), weight gain, joint pain, bronchitis, sore throat, runny or stuffy nose, sinusitis, skin rash, itching, urinary tract disorders, and vaginitis.
Cautions & Contraindications
Warnings & Precautions
Darifen ER should be used cautiously in patients who are prone to urinary retention or reduced gastrointestinal motility, as well as in those with impaired kidney or liver function.
Contraindications
Patients with urinary retention or gastric retention, and those with uncontrolled narrow-angle glaucoma, should not use this medicine. It is also not recommended for patients who are at risk of developing these conditions.
Pregnancy & Breastfeeding
Pregnancy Category C. Darifenacin should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus.
Lactation: It is not known whether Darifenacin passes into human breast milk, so caution should be exercised before giving Darifenacin to a breastfeeding woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Taking too much of an antimuscarinic medicine can cause severe antimuscarinic effects. If an overdose happens, ECG monitoring is recommended. In clinical trials, darifenacin was given at doses up to 75 mg, which is five times the maximum therapeutic dose, and the only sign of overdose was abnormal vision.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Darifenacin at 25° C and protect it from light.
Drug Interactions
Common questions about Darifen 7.5 mg
What is Darifen 7.5 mg Pr Tablet?
Darifen 7.5 mg Pr Tablet is a medicine that contains Darifenacin. It is made by The ACME Laboratories Ltd. It belongs to the BPH/ Urinary retention/ Urinary incontinence group of medicines.
What is Darifen used for?
Darifen ER is used to treat overactive bladder, helping relieve symptoms such as urgent, frequent, and sometimes uncontrollable urges to urinate.
What are the side effects of Darifen?
Dry mouth and constipation are the most common side effects experienced with this medicine. Other, less frequent side effects that have been reported include blurred or abnormal vision, back pain, dry skin, raised blood pressure, vomiting, swelling of the extremities (peripheral edema), weight gain, joint pain, bronchitis, sore throat, runny or stuffy nose, sinusitis, skin rash, itching, urinary tract disorders, and vaginitis.
Can I take Darifen during pregnancy or while breastfeeding?
Pregnancy Category C. Darifenacin should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Darifen?
Taking too much of an antimuscarinic medicine can cause severe antimuscarinic effects. If an overdose happens, ECG monitoring is recommended. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Darifen?
Store Darifenacin at 25° C and protect it from light.
Can I take other medicines with Darifen?
Some medicines can interact with Darifenacin, for example: Itraconazole, Nelfinavir, Ritonavir, Ketoconazole. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Darifen?
Darifen is a prescription (Rx) medicine. Take it as your doctor advises.