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These brands contain the same active ingredient (Danazol). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Danazol 200 is indicated for:
Pharmacology
Danazol works as a gonadotropin inhibitor by suppressing the pituitary-ovarian axis, likely through reduced output of pituitary gonadotropins. It also blunts the preovulatory surge of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which lowers ovarian estrogen production. Danazol may directly inhibit ovarian steroidogenesis; it can bind to androgen, progesterone, and glucocorticoid receptors, as well as to sex-hormone-binding globulin and corticosteroid-binding globulin, and it raises the metabolic clearance rate of progesterone. It may also help endometriosis regress by lowering IgG, IgM, and IgA concentrations, along with phospholipid and IgG isotype autoantibodies.
In endometriosis, the suppression of ovarian function causes both normal and ectopic endometrial tissue to become inactive and atrophic, leading to anovulation and the associated amenorrhea. In fibrocystic breast disease, the exact mechanism is unknown, but it may relate to reduced estrogenic stimulation from decreased ovarian estrogen production; a direct effect on steroid receptor sites in breast tissue is also possible. This can lead to the disappearance of nodularity, relief of pain and tenderness, and sometimes changes in the menstrual pattern. For hereditary angioedema, danazol corrects the underlying biochemical deficiency by raising serum concentrations of the deficient C1 esterase inhibitor, which in turn increases serum concentrations of the C4 component of the complement system.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Danazol is usually taken in up to 4 divided doses a day. Women who could become pregnant should start treatment during menstruation, preferably on the first day.
For endometriosis: 200 to 800 mg daily in up to 4 divided doses, adjusted to stop menstrual periods, usually for 6 months (up to 9 months in some cases).
For menorrhagia (heavy periods): daily doses of 100 to 200 mg have been found effective, but 200 mg daily for 3 months is usually enough to reduce menstrual blood flow to acceptable levels.
For severe cyclical mastalgia (breast pain linked to the menstrual cycle): 100 to 400 mg daily, usually for 3 to 6 months.
For benign breast cysts: 300 mg daily, usually for 3 to 6 months.
For gynaecomastia: 400 mg daily in up to 4 divided doses for 6 months. In adolescents, 200 mg daily, increased to 400 mg daily if there is no response after 2 months.
For pre-operative thinning of the endometrium: 400 to 800 mg daily in up to 4 divided doses for 3 to 6 weeks.
Children: Danazol is not used in children.
Side Effects
Danazol can cause nausea, dizziness, headache, fatigue, fever, backache, nervousness, anxiety, mood changes, changes in libido, vertigo, weight gain, and epigastric and pleuritic pain. Skin reactions are also reported, including rashes, photosensitivity and exfoliative dermatitis. Other effects are menstrual disturbances, vaginal dryness and irritation, flushing, and a reduction in breast size. Some people get musculo-skeletal spasm, joint pain and swelling, or hair loss. Danazol has androgenic effects too. These include acne, oily skin, oedema, hirsutism and voice changes, and rarely clitoral hypertrophy. There can be a temporary alteration in lipoproteins along with other metabolic changes, and insulin resistance. Thrombotic events have been reported. So have leucopenia, thrombocytopenia, eosinophilia, and reversible erythrocytosis or polycythaemia. Headache and visual disturbances may indicate benign intracranial hypertension.
Cautions & Contraindications
Warnings & Precautions
Use with caution in cardiac, hepatic or renal impairment, in elderly patients, and in those with polycythaemia, epilepsy, diabetes mellitus, hypertension, migraine, lipoprotein disorder, or a history of thrombosis or thromboembolic disease. If signs of virilization occur, such as voice changes or hirsutism, therapy should be stopped immediately.
Contraindications
Danazol should not be used in pregnancy or during breast-feeding. It is also contraindicated in people with impaired liver, kidney or heart function, porphyria, thromboembolic disease, or an androgen-dependent tumor. Abnormal vaginal bleeding that has not been fully investigated is another contraindication, and so is hypersensitivity to danazol.
Pregnancy & Breastfeeding
Danazol should not be used during pregnancy: it can cause virilization in a female fetus, especially with high doses taken over several weeks. Women taking this medicine should also avoid breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Danazol below 30°C, away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Danazol 200 200 mg
What is Danazol 200 200 mg Capsule?
Danazol 200 200 mg Capsule is a medicine that contains Danazol. It is made by Ibn Sina Pharmaceutical Ind. Ltd. It belongs to the Drugs affecting (inhibiting) gonadotrophin group of medicines.
What is Danazol 200 used for?
Danazol 200 is used for: Menstrual Disorder.
What are the side effects of Danazol 200?
Danazol can cause nausea, dizziness, headache, fatigue, fever, backache, nervousness, anxiety, mood changes, changes in libido, vertigo, weight gain, and epigastric and pleuritic pain. Skin reactions are also reported, including rashes, photosensitivity and exfoliative dermatitis.
Can I take Danazol 200 during pregnancy or while breastfeeding?
Danazol should not be used during pregnancy: it can cause virilization in a female fetus, especially with high doses taken over several weeks. Women taking this medicine should also avoid breastfeeding. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Danazol 200?
Store Danazol below 30°C, away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Danazol 200?
Some medicines can interact with Danazol, for example: Insulin Aspart [Protamine Crystallised], Biphasic Insulin Aspart, Regular Insulin Human + Isophane Insulin Human, Insulin Human [rDNA], Insulin Glargine, Gliclazide. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Danazol 200?
Danazol 200 is a prescription (Rx) medicine. Take it as your doctor advises.