Pricing
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All price changes →Indications & Uses
Dacarzin is indicated for:
Pharmacology
Dacarbazine is an antineoplastic agent, meaning it is used against cancer, and it is not specific to any one phase of the cell cycle. Doctors do not yet know exactly how it kills cells. Three possible mechanisms have been suggested. One is that it blocks DNA synthesis by acting as a purine analog. Another is that it works as an alkylating agent. The third is that it interacts with sulfydryl groups, which is linked to the inhibition of bacterial cell growth.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Malignant Melanoma: The recommended dose is 2 to 4.5 mg/kg per day for 10 days. The course may be repeated every 4 weeks. An alternative recommended dose is 250 mg/m2 per day by intravenous injection for 5 days, with the course repeated every 3 weeks.
Hodgkin's Disease: The recommended dose of Dacarbazine for treating Hodgkin's disease is 150 mg/m2 per day for 5 days, given in combination with other effective drugs. The course may be repeated every 4 weeks. An alternative recommended dose is 375 mg/m2 on day 1, given in combination with other effective drugs, and repeated every 15 days.
Side Effects
Loss of appetite, nausea and vomiting are the most common side effects of dacarbazine. More than 90% of patients experience them with the first few doses. Vomiting lasts 1 to 12 hours and is only partly and unpredictably relieved by phenobarbital and/or prochlorperazine. In rare cases, nausea and vomiting have been severe enough to require stopping Dacarzin for Injection. Diarrhoea has rarely been reported with Dacarzin for Injection. One helpful measure is to limit the patient's intake of food by mouth for 4 to 6 hours before treatment. Patients usually become tolerant of these symptoms quickly, which suggests a central nervous system mechanism may be involved, and the symptoms generally settle after the first 1 or 2 days.
Cautions & Contraindications
Warnings & Precautions
Hospital admission is not always required, but facilities for adequate laboratory monitoring must be available. If Dacarzin leaks into the surrounding tissue (extravasation) during intravenous administration, it may cause tissue damage and severe pain. Local pain, burning and irritation at the injection site may be relieved by applying hot packs to the area. The carcinogenicity of Dacarzin has been studied in rats and mice. In rats, Dacarzin induced proliferative endocardial lesions, including fibrosarcomas and sarcomas. In mice, administration of Dacarzin led to the development of angiosarcomas of the spleen.
Contraindications
Dacarbazine should not be used in patients who have previously shown hypersensitivity to it.
Pregnancy & Breastfeeding
Pregnancy Category C. Dacarbazine for Injection has been shown to be teratogenic in rats when given at doses 20 times the human daily dose on day 12 of gestation. When male rats received 10 times the human daily dose of dacarbazine (twice weekly for 9 weeks), their libido was not affected, although female rats mated with these males showed a higher incidence of resorptions than controls. In rabbits, dacarbazine given at 7 times the human daily dose on Days 6 to 15 of gestation caused fetal skeletal anomalies. No adequate, well-controlled studies have been conducted in pregnant women. Dacarbazine for Injection should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Whether this drug passes into human milk is not known. Because many drugs do pass into human milk, and given the tumorigenic potential Dacarbazine for Injection has shown in animal studies, a decision should be made to discontinue either nursing or the drug, taking into account how important the drug is to the mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
In an overdose of Dacarbazine, give supportive treatment and keep checking the blood cell counts.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Dacarbazine in a refrigerator, at 2°C to 8°C.
Drug Interactions
Common questions about Dacarzin 200 mg
What is Dacarzin 200 mg IV Infusion?
Dacarzin 200 mg IV Infusion is a medicine that contains Dacarbazine. It is made by Beacon Pharmaceuticals PLC. It belongs to the Cytotoxic Chemotherapy group of medicines.
What is Dacarzin used for?
Dacarzin is used for: Cancer.
What are the side effects of Dacarzin?
Loss of appetite, nausea and vomiting are the most common side effects of dacarbazine. More than 90% of patients experience them with the first few doses.
Can I take Dacarzin during pregnancy or while breastfeeding?
Pregnancy Category C. Dacarbazine for Injection has been shown to be teratogenic in rats when given at doses 20 times the human daily dose on day 12 of gestation. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Dacarzin?
In an overdose of Dacarbazine, give supportive treatment and keep checking the blood cell counts. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Dacarzin?
Keep Dacarbazine in a refrigerator, at 2°C to 8°C.
Can I take other medicines with Dacarzin?
Some medicines can interact with Dacarbazine, for example: Rifampicin, Allopurinol, Methoxsalen, Mercaptopurine, Azathioprine, Phenytoin. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Dacarzin?
Dacarzin is a prescription (Rx) medicine. Take it as your doctor advises.