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Indications & Uses
Vitamin B12 is used to treat pernicious anemia and Vitamin B12 deficiency caused by low dietary intake. It is also indicated for thyrotoxicosis, hemorrhage, malignancy, liver or kidney disease, gastric bypass surgery, total or partial gastrectomy, gluten enteropathy (sprue), folic acid deficiency, and macrocytic anaemia.
Pharmacology
Vitamin B12 (cyanocobalamin) is needed for the body to keep producing red blood cells normally and to support the synthesis of nucleoproteins and myelin, along with normal cell reproduction and growth. It acts as a coenzyme in metabolic processes, including protein synthesis and carbohydrate metabolism, and plays a role in cell replication and blood cell formation.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Usual Adult Dose for Pernicious Anemia: Initial dose, 1000 mcg by intramuscular or deep subcutaneous injection once daily for 6 to 7 days. If clinical improvement and reticulocyte response are seen from the above dosing, give 100 mcg every other day for 7 doses, then 100 mcg every 3 to 4 days for 2 to 3 weeks, then a maintenance dose of 100 to 1000 mcg monthly. Administer concomitant folic acid if needed. Chronic treatment should be done with an oral preparation in patients with normal intestinal absorption. Usual Adult Dose for B12 Nutritional Deficiency: 25 to 2000 mcg orally daily. Usual Adult Dose for Schilling Test: 1000 mcg intramuscularly is the flushing dose. Usual Pediatric Dose for B12 Nutritional Deficiency: 0.5 to 3 mcg daily.
Side Effects
Side effects reported with cyanocobalamin include arthralgia, dizziness, headache and nasopharyngitis, each in about 12% of people. Other reported effects are anaphylaxis, angioedema, congestive heart failure, peripheral vascular disease, pulmonary edema, diarrhea, dyspepsia, polycythemia vera, sore throat, nervousness, rhinitis, glossitis and hypoesthesia.
Cautions & Contraindications
Warnings & Precautions
Intensive treatment of vitamin B12-deficient megaloblastic anemia can lower potassium levels enough to cause sudden death. It should be used cautiously in patients with Leber's hereditary optic neuropathy. Thrombocytosis (a rise in platelet count) may also occur when severe vitamin B12 megaloblastic anemia is treated.
Contraindications
Leber's disease and tobacco amblyopia.
Pregnancy & Breastfeeding
Pregnancy Category A. Adequate and well-controlled studies in humans have failed to show any risk to the baby during the first trimester of pregnancy, and there is no evidence of risk in later trimesters either.
Lactation: This medicine passes into breast milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Drug Interactions
Common questions about Cynomin 250 mcg/ml
What is Cynomin 250 mcg/ml IM/SC Injection?
Cynomin 250 mcg/ml IM/SC Injection is a medicine that contains Cyanocobalamin. It is made by Jayson Pharmaceuticals Ltd. It belongs to the Vitamin-B preparations group of medicines.
What is Cynomin used for?
Vitamin B12 is used to treat pernicious anemia and Vitamin B12 deficiency caused by low dietary intake. It is also indicated for thyrotoxicosis, hemorrhage, malignancy, liver or kidney disease, gastric bypass surgery, total or partial gastrectomy, gluten enteropathy (sprue), folic acid deficiency, and macrocytic anaemia.
What are the side effects of Cynomin?
Side effects reported with cyanocobalamin include arthralgia, dizziness, headache and nasopharyngitis, each in about 12% of people. Other reported effects are anaphylaxis, angioedema, congestive heart failure, peripheral vascular disease, pulmonary edema, diarrhea, dyspepsia, polycythemia vera, sore throat, nervousness, rhinitis, glossitis and hypoesthesia.
Can I take Cynomin during pregnancy or while breastfeeding?
Pregnancy Category A. Adequate and well-controlled studies in humans have failed to show any risk to the baby during the first trimester of pregnancy, and there is no evidence of risk in later trimesters either. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Can I take other medicines with Cynomin?
Some medicines can interact with Cyanocobalamin, for example: Hydroxocobalamin, Methyldopa, Cimetidine, Colchicine, Cholestyramine. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Cynomin?
Cynomin is a prescription (Rx) medicine. Take it as your doctor advises.