Pricing
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All price changes →Indications & Uses
Cynomin-H is indicated for:
Pharmacology
Hydroxocobalamin (Vitamin B12) is a water-soluble vitamin. It is readily converted in the body into active coenzyme forms: as methylcobalamin, it takes part in converting homocysteine to methionine, and as deoxyadenosylcobalamin, in converting methylmalonyl-CoA to succinyl-CoA. These active coenzymes, methylcobalamin and 5-deoxyadenosylcobalamin, are essential for cell growth and replication.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults and children may use the following dosage schemes.
For Addisonian pernicious anaemia and other macrocytic anaemias without neurological involvement: the initial dose is 250 to 1,000 micrograms by intramuscular injection on alternate days for one to two weeks, then 250 micrograms weekly until the blood count returns to normal. The maintenance dose is 1,000 micrograms monthly.
For Addisonian pernicious anaemia and other macrocytic anaemias with neurological complications: the initial dose is 1,000 micrograms by intramuscular injection on alternate days for as long as improvement continues. The maintenance dose is 1,000 micrograms monthly.
For prophylaxis of macrocytic anaemia associated with vitamin B12 deficiency arising from gastrectomy, certain malabsorption syndromes, or strict vegetarianism: 250 to 1,000 micrograms monthly.
For the Schilling test: an intramuscular injection of 1,000 micrograms of hydroxocobalamin is an essential part of this test.
Side Effects
Sensitisation to Cynomin-H is rare but it may present as an itching rash, chills, fever, hot flushes, nausea, and dizziness, and in exceptional cases as anaphylactic shock. Acneiform and bullous eruptions have also been reported, though rarely.
Cautions & Contraindications
Warnings & Precautions
Cynomin-H should not be given until the diagnosis has been confirmed, if at all possible. The dosage schedules above are usually adequate, but the blood should be checked regularly during treatment. If megaloblastic anaemia does not respond, folate metabolism should be looked into. Doses above 10 micrograms a day can produce a haematological response even in patients who are folate deficient, so giving it indiscriminately may mask the true diagnosis. Cardiac arrhythmias linked to hypokalaemia have been reported during the early stages of therapy, so plasma potassium levels should be monitored over this period.
Contraindications
Anaphylaxis; tobacco amblyopia.
Pregnancy & Breastfeeding
Hydroxocobalamin should not be used to treat megaloblastic anaemia occurring in pregnancy.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Hydroxocobalamin below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Cynomin-H 1000 mcg/ml
What is Cynomin-H 1000 mcg/ml IM Injection?
Cynomin-H 1000 mcg/ml IM Injection is a medicine that contains Hydroxocobalamin. It is made by Jayson Pharmaceuticals Ltd. It belongs to the Antidote preparations group of medicines.
What is Cynomin-H used for?
Cynomin-H is used for: Anemia.
What are the side effects of Cynomin-H?
Sensitisation to Cynomin-H is rare but it may present as an itching rash, chills, fever, hot flushes, nausea, and dizziness, and in exceptional cases as anaphylactic shock. Acneiform and bullous eruptions have also been reported, though rarely.
Can I take Cynomin-H during pregnancy or while breastfeeding?
Hydroxocobalamin should not be used to treat megaloblastic anaemia occurring in pregnancy. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Cynomin-H?
Store Hydroxocobalamin below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Cynomin-H?
Some medicines can interact with Hydroxocobalamin, for example: Chloramphenicol, Cyanocobalamin, Colchicine, Cholestyramine, Ethanol 70%, Neomycin Sulphate. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Cynomin-H?
Cynomin-H is a prescription (Rx) medicine. Take it as your doctor advises.