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All price changes →Indications & Uses
Minocycline Hydrochloride (Cynocap) is taken by mouth to treat infections caused by tetracycline sensitive organisms, and also some tetracycline resistant strains of staphylococci. It is used for acne, skin and soft tissue infections, ophthalmological infections, acute and chronic bronchitis, bronchiectasis, lung abscess, and ear, nose and throat infections. It is also used for pelvic inflammatory disease, nocardiosis, urinary tract infections, gonorrhoea, non-gonococcal urethritis and prostatitis. Minocycline Hydrochloride may be used as preventive treatment in people who carry meningococcal bacteria without any symptoms. It is also indicated to prevent infection before and after operations.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For routine antibiotic use, the adult dose of minocycline hydrochloride is 200 mg daily in divided doses. For acne, it's 50 mg twice daily for at least 6 weeks.
In gonorrhoea, men take 200 mg first, then 100 mg every 12 hours for a minimum of 4 days. Cultures should be done after the therapy, within 2 to 3 days. Women may need a more prolonged course.
To prevent infection in asymptomatic meningococcal carriers, the dose is 100 mg twice daily for 5 days, followed by treatment with rifampicin.
If there's no satisfactory response after six months, minocycline should be stopped and other therapies considered. If it is to be continued for longer than six months, patients should be monitored at least at three monthly intervals after that for signs and symptoms of hepatitis or SLE.
Side Effects
Side effects reported with Minocycline Hydrochloride are oral and anogenital candidiasis, vulvovaginitis, eosinophilia, leucopenia, neutropenia, thrombocytopenia, haemolytic anaemia, pancytopenia, agranulocytosis, anaphylaxis, anaphylactoid reaction, hypersensitivity, pulmonary infiltrates, anaphylactoid purpura, polyarthritis nodosa, abnormal thyroid function, brown-black discolouration of the thyroid, anorexia, dizziness, headache, hypaesthesia, paraesthesia, intracranial hypertension, vertigo, bulging fontanelle, convulsions, sedation, impaired hearing, tinnitus, myocarditis, pericarditis, cough, dyspnoea, bronchospasm, exacerbation of asthma, pulmonary eosinophilia, pneumonitis, diarrhoea, nausea, stomatitis, discolouration of teeth, vomiting, dyspepsia, dysphagia, enamel hypoplasia, enterocolitis, oesophagitis, oesophageal ulceration, glossitis, pancreatitis, pseudomembranous colitis, increased liver enzymes, hepatitis, autoimmune hepatotoxicity, hepatic cholestasis, hepatic failure, hyperbilirubinemia, jaundice, autoimmune hepatitis, alopecia, erythema multiforme, erythema nodosum, fixed drug eruption, hyperpigmentation of the skin, photosensitivity, pruritus, rash, urticaria, vasculitis, angioedema, exfoliative dermatitis, hyperpigmentation of nails, Stevens-Johnson syndrome, toxic epidermal necrolysis, Drug reaction with eosinophilia and systemic symptoms (DRESS), arthralgia, lupus-like syndrome, myalgia, arthritis, bone discolouration, cases of systemic lupus erythematosus (SLE), joint stiffness, joint swelling, increased serum urea, acute renal failure, interstitial nephritis, balanitis, fever, etc. Death has been reported in some cases involving these syndromes. Hyperpigmentation has also been reported at many body sites, including the skin, nails, teeth, oral mucosa, bones, thyroid, eyes (including sclera and conjunctiva), breast milk, lacrimal secretions and perspiration. The discolouration is blue, black, grey or muddy-brown, and it may be localised or diffuse. The skin is the site reported most often. Pigmentation often reverses when minocycline is stopped, although it can take several months and in some cases it may persist. The generalised muddy-brown skin pigmentation may persist, particularly in areas exposed to the sun.
Cautions & Contraindications
Warnings & Precautions
Minocycline has been reported to cause breathing difficulties, including dyspnoea, bronchospasm, worsening of asthma, pulmonary eosinophilia and pneumonitis. A patient who develops breathing difficulties should seek urgent medical advice, and minocycline should be stopped. In the paediatric population, all tetracyclines form a stable calcium complex in any bone forming tissue. A faster fibula growth rate has been seen in premature babies given oral tetracyclines. Tetracyclines are also known to cause a yellow to brown discoloration of the teeth and enamel hypoplasia in a developing child or foetus. In hepatic impairment, Minocycline Hydrochloride should be used with caution in patients with hepatic dysfunction, or together with drugs that may harm the liver, alcohol included. For auto-immune disorders, rare cases of auto-immune hepatotoxicity and isolated cases of systemic lupus erythematosus (SLE) have been reported. If signs or symptoms of SLE or hepatotoxicity appear, minocycline should be stopped. In renal impairment, studies show no significant drug accumulation in patients with mild to moderate renal impairment when the recommended dosages are used. In severe renal impairment, the dose may need to be reduced and renal function monitored. Micro-organisms can develop cross resistance to tetracyclines, and patients can develop cross sensitivity. Minocycline Hydrochloride should be stopped if there are signs or symptoms of overgrowth of resistant organisms. As with other tetracyclines, bulging fontanelles in infants and benign intracranial hypertension in juveniles and adults have been reported. The presenting features were headache and visual disturbances, including blurring of vision, scotoma and diplopia. Permanent vision loss has been reported. Treatment should stop if there is evidence of raised intracranial pressure. Minocycline may cause hyperpigmentation at various body sites, as other tetracyclines do. It can appear whatever the dose or duration of therapy, but it develops more commonly during long term treatment. Patients should be advised to report any unusual pigmentation without delay, and minocycline should be stopped. Tetracyclines are known to cause photosensitivity reactions. These patients should be warned to avoid direct exposure to natural or artificial sunlight and to stop the medicine at the first sign of skin discomfort.
Contraindications
Minocycline should not be given to people who are allergic to tetracyclines or who have systemic lupus erythematosus. It is also contraindicated in pregnancy, during breastfeeding, in complete renal failure, and in children under 12 years.
Pregnancy & Breastfeeding
Minocycline must not be used during pregnancy or while breastfeeding. Animal studies show that tetracyclines cross the placenta. They have been found in foetal tissues and can be toxic to the developing foetus, which is linked to slowed skeletal development. Animals treated in early pregnancy also showed embryotoxicity.
Using tetracyclines in the last half of pregnancy, when the teeth are forming, may cause permanent discolouration of the teeth. This is more common with long term use or repeated short term use. Enamel hypoplasia has been reported as well.
Tetracyclines have also been detected in the milk of breastfeeding women. The developing infant may get permanent tooth discolouration, and enamel hypoplasia has been reported.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Renal impairment: Minocycline Hydrochloride is given at the same dose as in adults, even when the renal impairment is mild to moderate. Caution is advised in patients with severe renal impairment.
Paediatric population: Minocycline Hydrochloride is not recommended in children under 12 years. For children over 12 years, the dose is 50mg every 12 hours.
Overdose
In an overdose of Minocycline Hydrochloride, the effects seen most often are dizziness, nausea and vomiting. Treatment is gastric lavage along with appropriate supportive care. Antacids and calcium salts reduce how much minocycline is absorbed, but there is no specific antidote. Haemodialysis and peritoneal dialysis don't remove Minocycline Hydrochloride in any significant amount.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Minocycline Hydrochloride in a cool, dry place, away from light, and below 25°C.
Drug Interactions
Common questions about Cynocap 50 mg
What is Cynocap 50 mg Capsule?
Cynocap 50 mg Capsule is a medicine that contains Minocycline Hydrochloride. It is made by Sharif Pharmaceuticals Ltd. It belongs to the Tetracycline group of drugs group of medicines.
What is Cynocap used for?
Minocycline Hydrochloride (Cynocap) is taken by mouth to treat infections caused by tetracycline sensitive organisms, and also some tetracycline resistant strains of staphylococci. It is used for acne, skin and soft tissue infections, ophthalmological infections, acute and chronic bronchitis, bronchiectasis, lung abscess, and ear, nose and throat infections.
What are the side effects of Cynocap?
Side effects reported with Minocycline Hydrochloride are oral and anogenital candidiasis, vulvovaginitis, eosinophilia, leucopenia, neutropenia, thrombocytopenia, haemolytic anaemia, pancytopenia, agranulocytosis, anaphylaxis, anaphylactoid reaction, hypersensitivity, pulmonary infiltrates, anaphylactoid purpura, polyarthritis nodosa, abnormal thyroid function, brown-black discolouration of the thyroid, anorexia, dizziness, headache, hypaesthesia, paraesthesia, intracranial hypertension, vertigo, bulging fontanelle, convulsions, sedation, impaired hearing, tinnitus, myocarditis, pericarditis, cough, dyspnoea, bronchospasm, exacerbation of asthma, pulmonary eosinophilia, pneumonitis, diarrhoea, nausea, stomatitis, discolouration of teeth, vomiting, dyspepsia, dysphagia, enamel hypoplasia, enterocolitis, oesophagitis, oesophageal ulceration, glossitis, pancreatitis, pseudomembranous colitis, increased liver enzymes, hepatitis, autoimmune hepatotoxicity, hepatic cholestasis, hepatic failure, hyperbilirubinemia, jaundice, autoimmune hepatitis, alopecia, erythema multiforme, erythema nodosum, fixed drug eruption, hyperpigmentation of the skin, photosensitivity, pruritus, rash, urticaria, vasculitis, angioedema, exfoliative dermatitis, hyperpigmentation of nails, Stevens-Johnson syndrome, toxic epidermal necrolysis, Drug reaction with eosinophilia and systemic symptoms (DRESS), arthralgia, lupus-like syndrome, myalgia, arthritis, bone discolouration, cases of systemic lupus erythematosus (SLE), joint stiffness, joint swelling, increased serum urea, acute renal failure, interstitial nephritis, balanitis, fever, etc. Death has been reported in some cases involving these syndromes.
Can I take Cynocap during pregnancy or while breastfeeding?
Minocycline must not be used during pregnancy or while breastfeeding. Animal studies show that tetracyclines cross the placenta. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Cynocap?
In an overdose of Minocycline Hydrochloride, the effects seen most often are dizziness, nausea and vomiting. Treatment is gastric lavage along with appropriate supportive care. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Cynocap?
Keep Minocycline Hydrochloride in a cool, dry place, away from light, and below 25°C.
Can I take other medicines with Cynocap?
Some medicines can interact with Minocycline Hydrochloride, for example: Isotretinoin, Ergometrine Maleate, Magnesium Carbonate 1X 47 gm/. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Cynocap is already among the lowest-priced brands of Minocycline Hydrochloride at this strength.
Do I need a prescription for Cynocap?
Cynocap is a prescription (Rx) medicine. Take it as your doctor advises.