Pricing
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Coxpar is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults: the recommended dose of Parecoxib is 40 mg given into a vein (IV) or into a muscle (IM). After that, 20 mg or 40 mg can be given every 6 to 12 hours as required, and the total must not go above 80 mg a day. The cardiovascular risk of COX-2 specific inhibitors may rise with the dose and with how long the medicine is used, so use the shortest duration possible and the lowest effective daily dose. There is limited clinical experience with Parecoxib beyond three days.
Elderly: a dose change is not generally necessary in patients aged 65 years or more. But if an elderly patient weighs less than 50 kg, start with half the usual recommended dose of Parecoxib and lower the maximum daily dose to 40 mg.
Children: the safety and efficacy of parecoxib in children under 18 years old have not been established, and no data are available. For this reason, parecoxib is not recommended for them.
Side Effects
The common side effects of parecoxib include changes in blood pressure, which can go up or down. You may get back pain, and your ankles, legs and feet may swell because of fluid retention. Some people feel numb, and the skin may lose its sensitivity to pain and touch. Parecoxib can also upset the stomach, causing vomiting, stomach ache, indigestion, constipation, bloating and wind. Tests may show abnormal kidney function. You may feel agitated or find it hard to sleep, and dizziness can happen too. There is a risk of anaemia, meaning changes in the red blood cells after an operation, which may cause fatigue and breathlessness. You may get a sore throat or difficulty breathing (shortness of breath). Your skin may be itchy, and you may pass less urine than usual. Other common effects are dry socket (inflammation and pain after a tooth extraction), increased sweating, and low levels of potassium in blood test results.
Pregnancy & Breastfeeding
Parecoxib is suspected to cause serious birth defects when it is administered during the last trimester of pregnancy. Like other medicines known to inhibit prostaglandin, it may cause premature closure of the ductus arteriosus or uterine inertia. NSAID use in the second or third trimester may cause foetal renal dysfunction, and in severe cases this can lead to a reduction in amniotic fluid volume or oligohydramnios. These effects may appear shortly after treatment starts and are usually reversible. Pregnant women on NSAIDs should be closely monitored for amniotic fluid volume. Parecoxib is contraindicated in the third trimester of pregnancy. Administration of a single dose of parecoxib to lactating women after caesarean section led to a relatively small amount of parecoxib and its active metabolite valdecoxib passing into human milk. This gave a low relative dose for the infant (approximately 1% of the weight-adjusted maternal dose). Parecoxib must not be administered to women who breast-feed.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
When people have taken too much Parecoxib, the adverse reactions reported are the same ones that have also been described with the recommended doses. If an overdose happens, the patient is managed with symptomatic and supportive care. Haemodialysis does not remove valdecoxib, and diuresis or alkalisation of the urine may not help either, because valdecoxib is highly bound to protein.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Parecoxib below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Common questions about Coxpar 40 mg
What is Coxpar 40 mg IM/IV Injection?
Coxpar 40 mg IM/IV Injection is a medicine that contains Parecoxib. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Non-steroidal Anti-inflammatory Drugs (NSAIDs) group of medicines.
What is Coxpar used for?
Coxpar is used for: Pain.
What are the side effects of Coxpar?
The common side effects of parecoxib include changes in blood pressure, which can go up or down. You may get back pain, and your ankles, legs and feet may swell because of fluid retention.
Can I take Coxpar during pregnancy or while breastfeeding?
Parecoxib is suspected to cause serious birth defects when it is administered during the last trimester of pregnancy. Like other medicines known to inhibit prostaglandin, it may cause premature closure of the ductus arteriosus or uterine inertia. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Coxpar?
When people have taken too much Parecoxib, the adverse reactions reported are the same ones that have also been described with the recommended doses. If an overdose happens, the patient is managed with symptomatic and supportive care. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Coxpar?
Store Parecoxib below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Do I need a prescription for Coxpar?
Coxpar is a prescription (Rx) medicine. Take it as your doctor advises.