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Indications & Uses
Coversyl is indicated for:
Pharmacology
Perindopril Arginine contains perindopril, a nonsulphydryl ACE inhibitor used to treat hypertension. After you swallow it, the body quickly hydrolyses perindopril to perindoprilat, which is its main active metabolite.
ACE catalyses the conversion of angiotensin I to angiotensin II, a substance that narrows the blood vessels (a vasoconstrictor). Angiotensin II also stimulates the adrenal cortex to secrete aldosterone. When ACE activity is inhibited, angiotensin II levels fall, so there is less vasoconstriction and less aldosterone secretion. The drop in aldosterone may cause a small rise in serum potassium.
Lower angiotensin II also means the kidney's renin secretion is no longer held back by negative feedback, and this raises plasma renin activity. Perindopril may also interfere with the breakdown of bradykinin, a vasodepressor peptide. Nobody knows yet whether this effect adds to the therapeutic action of perindopril.
The way perindopril lowers BP appears to come mainly from suppression of the RAAS.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Hypertension: Take one Perindopril 4 tablet once a day, preferably in the morning and before food. If needed, the doctor may raise the dose to 8 mg after 1 month of treatment.
Stable coronary artery disease: Start with Perindopril 4 once a day for two weeks. After that the dose goes up to 8 mg once a day, depending on kidney function and as long as the 4 mg dose is well tolerated. Elderly patients should take Perindopril 2 mg once a day for one week, then Perindopril 4 once a day the next week, before the dose is raised up to 8 mg once a day, again depending on kidney function. The dose should be increased only if the previous lower dose is well tolerated.
Congestive heart failure: Perindopril should be started under close medical supervision, with a starting dose of 2 mg in the morning. If necessary, the dose may be increased to 4 mg. Elderly patients should start at a low daily dose (4 mg or less) and the dose should be increased slowly as needed. Experience with doses above 8 mg is limited.
Side Effects
With perindopril arginine, rare and mild side effects have been reported, usually at the start of treatment. These are cough, fatigue, asthenia, headache, and disturbances of mood and/or sleep. Less often, people have had taste impairment, epigastric discomfort, nausea, abdominal pain and rash. Blood urea and creatinine may rise, but this is reversible. Some patients have had proteinuria. Rarely, perindopril arginine has been linked with angioneurotic edema, and with a decrease in hemoglobin, red cells and platelets.
Cautions & Contraindications
Warnings & Precautions
Use Perindopril Arginine with caution in renovascular hypertension, surgery/anesthesia and renal failure. In renal failure, adjust the dose carefully according to the creatinine clearance. Symptomatic hypotension is rarely seen, but it is more likely in patients who are volume-depleted, in those receiving diuretics, and with the first two doses. If a patient is being treated with a diuretic, stop the diuretic 3 days before starting Perindopril Arginine. A diuretic may be given in combination later if necessary, but potassium-sparing diuretics are not recommended. Combining the medicine with neuroleptics or imipramine-type drugs may increase the hypotensive effect. Serum lithium concentrations may rise during lithium therapy.
Contraindications
Perindopril should not be given to anyone who has had a hypersensitivity reaction to Perindopril before. It is also contraindicated for managing hypertension in children, and during pregnancy and lactation.
Pregnancy & Breastfeeding
Perindopril should not be used during pregnancy or while breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Perindopril Arginine below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Coversyl 8 mg
What is Coversyl 8 mg Tablet?
Coversyl 8 mg Tablet is a medicine that contains Perindopril Arginine. It is made by Servier Bangladesh Operation. It belongs to the Angiotensin-converting enzyme (ACE) inhibitors group of medicines.
What is Coversyl used for?
Coversyl is used for: Hypertension, Heart Failure.
What are the side effects of Coversyl?
With perindopril arginine, rare and mild side effects have been reported, usually at the start of treatment. These are cough, fatigue, asthenia, headache, and disturbances of mood and/or sleep.
Can I take Coversyl during pregnancy or while breastfeeding?
Perindopril should not be used during pregnancy or while breastfeeding. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Coversyl?
Store Perindopril Arginine below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Coversyl?
Some medicines can interact with Perindopril Arginine, for example: Aspirin, Cyclosporine, Heparin Sodium. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Coversyl is already among the lowest-priced brands of Perindopril Arginine at this strength.
Do I need a prescription for Coversyl?
Coversyl is a prescription (Rx) medicine. Take it as your doctor advises.