Pricing
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Indications & Uses
Coveram is indicated for:
Pharmacology
Perindopril is a nonsulphydryl ACE inhibitor, and it is used to treat hypertension. After it is taken by mouth, it is quickly hydrolysed to perindoprilat, its main active metabolite. ACE catalyses the conversion of angiotensin I to angiotensin II, which is a vasoconstrictor. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. When ACE activity is inhibited, angiotensin II levels fall, so there is less vasoconstriction and less aldosterone secretion. The fall in aldosterone may cause a small increase in serum potassium. Lower angiotensin II also removes the negative feedback on renal renin secretion, and this raises plasma renin activity. Perindopril may also interfere with the breakdown of bradykinin, a vasodepressor peptide. It is not known whether this effect adds to the therapeutic activity of perindopril. The way perindopril lowers BP appears to come mainly from suppression of the RAAS.
Amlodipine is a dihydropyridine calcium-channel blocker with a long duration of action. It is used for hypertension and angina pectoris. It acts on the myocardial cells, the cells within the specialized conducting system of the heart, and the cells of vascular smooth muscle. Its main result is vasodilation, with reduced peripheral resistance, blood pressure and afterload, increased coronary blood flow and a reflex increase in coronary heart rate. This in turn raises myocardial oxygen supply and cardiac output.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended dose of Perindopril Arginine + Amlodipine is one tablet a day, taken as a single dose. It's best taken in the morning, before a meal. Perindopril and amlodipine can be used for different clinical indications, so any dose change should rest on clinical judgment and the individual patient's profile.
To adjust the dose, the doctor can raise or lower perindopril, amlodipine or both. This is done with separate perindopril and/or amlodipine products, within the recommended dose range, until clinical stability is re-established. When adjusting, check the Product Information of the individual perindopril and/or amlodipine products being used.
If the dose needs to come down, separate products should be considered, either amlodipine 2.5 mg or a dose of perindopril equivalent to perindopril arginine 2.5 mg, until clinical stability is re-established. Food may reduce the hepatic biotransformation of perindopril to perindoprilat.
Side Effects
Perindopril arginine with amlodipine is taken as one combined medicine, and the side effects most often reported are those seen when perindopril and amlodipine are given separately. These are oedema, somnolence, dizziness and headache (especially at the beginning of treatment). Others are dysgeusia, paraesthesia, visual impairment (including diplopia), tinnitus, vertigo, palpitations and flushing. Hypotension (and effects related to hypotension), dyspnoea and cough are also reported. Digestive effects include abdominal pain, nausea, vomiting, dyspepsia, change of bowel habit, diarrhoea and constipation. On the skin, people may get pruritus, rash or exanthema. The remaining reactions are joint swelling (ankle swelling), muscle spasms, fatigue and asthenia.
Cautions & Contraindications
Contraindications
Don't give Perindopril Arginine + Amlodipine to anyone who has had a hypersensitivity reaction before to either of the active ingredients, perindopril or amlodipine. The same applies to any ACE inhibitor, any dihydropyridine, or any of the excipients in this preparation. It is also contraindicated during pregnancy and in women who are breastfeeding.
Pregnancy & Breastfeeding
Don't start Perindopril Arginine + Amlodipine during pregnancy. If a patient is planning a pregnancy, she should be moved to another antihypertensive treatment that has an established safety record in pregnancy. Once pregnancy is diagnosed, stop this preparation straight away and, if appropriate, begin an alternative treatment. No animal studies of this preparation have been done in lactation.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Perindopril Arginine + Amlodipine in a dry place, below 25⁰C. Keep it out of reach of children.
Common questions about Coveram 4 mg+10 mg
What is Coveram 4 mg+10 mg Tablet?
Coveram 4 mg+10 mg Tablet is a medicine that contains Perindopril Arginine + Amlodipine. It is made by Servier Bangladesh Operation. It belongs to the Combined antihypertensive preparations group of medicines.
What is Coveram used for?
Coveram is used for: Hypertension.
What are the side effects of Coveram?
Perindopril arginine with amlodipine is taken as one combined medicine, and the side effects most often reported are those seen when perindopril and amlodipine are given separately. These are oedema, somnolence, dizziness and headache (especially at the beginning of treatment).
Can I take Coveram during pregnancy or while breastfeeding?
Don't start Perindopril Arginine + Amlodipine during pregnancy. If a patient is planning a pregnancy, she should be moved to another antihypertensive treatment that has an established safety record in pregnancy. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Coveram?
Keep Perindopril Arginine + Amlodipine in a dry place, below 25⁰C. Keep it out of reach of children.
Is there a cheaper medicine with the same ingredient?
Coveram is already among the lowest-priced brands of Perindopril Arginine + Amlodipine at this strength.
Do I need a prescription for Coveram?
Coveram is a prescription (Rx) medicine. Take it as your doctor advises.