Cortigen Ear Drops
Rx300 mg • Eye and Ear Drops
Indications & Uses
Cortigen Ear Drops is indicated for:
Pharmacology
Gentamicin is an aminoglycoside antibiotic with bactericidal activity against many Gram-negative bacteria and some Gram-positive strains. It is actively transported across the bacterial cell membrane, where it binds to a specific receptor protein on the 30S subunit of bacterial ribosomes. This disrupts the initiation complex formed between mRNA and the 30S subunit, blocking protein synthesis. As a result, DNA may be misread, leading to the production of nonfunctional proteins, while existing polyribosomes break apart and lose their ability to make protein. Hydrocortisone, for its part, reduces the formation, release, and activity of the body's natural inflammatory mediators and also modifies the immune response.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage for Middle Ear Infection: Instill 2 to 4 drops in the affected ear three to four times a day and at night, or more often if needed. Warm the suspension by holding the bottle in the hand for one or two minutes, since instilling a cold suspension may cause dizziness. The patient should lie down with the affected ear facing upward, and the drops should then be instilled. The tragus should then be pumped 5 times by pressing inward to help the drops penetrate into the middle ear. This position should be held for two minutes. Repeat for the opposite ear if necessary. Discard any unused portion once treatment is finished.
For Ear Canal Infection: Instill 2 to 4 drops in the affected ear three to four times a day and at night, or more often if needed. Warm the suspension by holding the bottle in the hand for one or two minutes, since instilling a cold suspension may cause dizziness. The patient should lie down with the affected ear facing upward, and the drops should then be instilled. This position should be held for two minutes to help the drops penetrate into the ear canal. Repeat for the opposite ear if necessary. Discard any unused portion once treatment is finished.
Side Effects
Ear discomfort or irritation is an uncommon side effect. More seriously, gentamicin can cause permanent hearing loss, whether partial or total, if it is given systemically or applied to open wounds or broken skin.
Cautions & Contraindications
Warnings & Precautions
Ear Drops should be stopped immediately if any sign of local or general hypersensitivity appears. Long-term, continuous use is not recommended. Extended use may lead to overgrowth of organisms that do not respond to this medicine, including fungi. If the infection has not improved within a week, culture and susceptibility testing should be carried out to confirm the causative organism and guide the choice of alternative treatment. For severe infections, this Ear Drops should be used alongside appropriate systemic antibiotic therapy.
Contraindications
Contraindications Avoid using this medicine if there is a known or suspected perforation of the eardrum, or any risk of one. These ear drops should not be used for viral infections of the outer ear canal unless a secondary bacterial infection is suspected that would respond to topical Gentamicin. Do not use if there is known hypersensitivity to Hydrocortisone, Gentamicin, or any other ingredient in the product.
Pregnancy & Breastfeeding
Pregnancy: There are no adequate, well controlled studies of Gentamicin + Hydrocortisone Acetate in pregnant women. When any corticosteroid is applied to the skin of pregnant animals, it can cause abnormalities in the development of the foetus. So a pregnant woman should use these ear drops with caution.
Nursing mothers: These ear drops should be given to a nursing woman only after a careful assessment of the possible risks and benefits.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Gentamicin + Hydrocortisone Acetate in a cool, dry place, away from light and protected from freezing. Throw away what's left one month after opening.
Drug Interactions
Common questions about Cortigen Ear Drops 300 mg
What is Cortigen Ear Drops 300 mg Eye and Ear Drops?
Cortigen Ear Drops 300 mg Eye and Ear Drops is a medicine that contains Gentamicin + Hydrocortisone Acetate. It is made by General Pharmaceuticals Ltd, Unit-2. It belongs to the Hydrocortisone & Combined preparations group of medicines.
What is Cortigen Ear Drops used for?
Cortigen Ear Drops is used for: Otitis Media.
What are the side effects of Cortigen Ear Drops?
Ear discomfort or irritation is an uncommon side effect. More seriously, gentamicin can cause permanent hearing loss, whether partial or total, if it is given systemically or applied to open wounds or broken skin.
Can I take Cortigen Ear Drops during pregnancy or while breastfeeding?
Pregnancy: There are no adequate, well controlled studies of Gentamicin + Hydrocortisone Acetate in pregnant women. When any corticosteroid is applied to the skin of pregnant animals, it can cause abnormalities in the development of the foetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Cortigen Ear Drops?
Keep Gentamicin + Hydrocortisone Acetate in a cool, dry place, away from light and protected from freezing. Throw away what's left one month after opening.
Can I take other medicines with Cortigen Ear Drops?
Some medicines can interact with Gentamicin + Hydrocortisone Acetate, for example: Carbamazepine, Gentamicin, Rifampicin, Hydrocortisone, Amphotericin B, Cisplatin. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Cortigen Ear Drops?
Cortigen Ear Drops is a prescription (Rx) medicine. Take it as your doctor advises.