More from Conart
Other strengths and forms by Advanced Chemical Industries PLC.
Indications & Uses
Conart is indicated for:
Pharmacology
Bumetanide is a loop diuretic known for acting quickly and for a relatively short duration. Studies show that a 1 mg dose delivers roughly the same diuretic effect as about 40 mg of furosemide, making it a considerably more potent medicine milligram for milligram.
It works mainly at the ascending limb of the loop of Henle, where it blocks the reabsorption of both sodium and chloride. There is also evidence that Bumetanide acts on the proximal tubule of the kidney: because phosphate is normally reabsorbed largely at this site, the increased loss of phosphate in the urine seen during Bumetanide-induced diuresis points to this extra site of action. This effect on the proximal tubule does not appear to result from inhibiting carbonic anhydrase. Bumetanide does not appear to have any meaningful effect on the distal tubule.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Oral: 1 mg in the morning, repeated after 6 to 8 hours if needed. In severe cases, 5 mg daily, increased by 5 mg every 12 to 24 hours according to response. Elderly patients: 500 micrograms daily may be sufficient.
1 to 2 mg, repeated after 20 minutes if needed. Elderly patients: 500 micrograms (1 ml of Bumecard) daily may be sufficient.
2 to 5 mg over 30 to 60 minutes. Elderly patients: 500 micrograms (1 ml of Bumecard) daily may be sufficient.
1 mg initially, then adjusted according to response. Elderly patients: 500 micrograms (1 ml of Bumecard) daily may be sufficient.
Paediatric use: Safety and effectiveness in paediatric patients below the age of 18 have not been established.
Side Effects
The side effects reported with Bumetanide, with the share of people affected, are muscle cramps (1.1%), dizziness (1.1%), hypotension (0.8%), headache (0.6%) and nausea (0.6%). Others include ECG changes (0.4%), musculoskeletal pain (0.2%), abdominal pain (0.2%), renal failure (0.1%) and thrombocytopenia (0.2%), among a few more.
Cautions & Contraindications
Warnings & Precautions
Serum potassium levels should be checked from time to time, and potassium supplements or a potassium-sparing diuretic added if needed.
Contraindications
Loop diuretics like this one should not be used in patients with severe hypokalaemia, severe hyponatraemia, or anuria, nor in those with renal failure or in comatose/precomatose states linked to liver cirrhosis.
Pregnancy & Breastfeeding
Pregnancy Category C. Well-controlled studies in pregnant women have not been done, so its safety in pregnancy has not been firmly established. It is also not known whether this medicine passes into breast milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Children and adolescents: safety and effectiveness of bumetanide have not been established in patients below the age of 18.
Overdose
Too much Bumetanide can cause a sudden and severe loss of water from the body, along with loss of volume and electrolytes. This leads to dehydration and a fall in blood volume, and the circulation can collapse. There is also a possibility of vascular thrombosis and embolism.
Treatment is to replace the lost fluid and electrolytes. This is done with careful monitoring of urine output, electrolyte output and serum electrolyte levels.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Bumetanide below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Conart 2 mg
What is Conart 2 mg Injection?
Conart 2 mg Injection is a medicine that contains Bumetanide. It is made by Advanced Chemical Industries PLC. It belongs to the Loop diuretics group of medicines.
What is Conart used for?
Conart is used for: Heart Failure, Edema.
What are the side effects of Conart?
The side effects reported with Bumetanide, with the share of people affected, are muscle cramps (1.1%), dizziness (1.1%), hypotension (0.8%), headache (0.6%) and nausea (0.6%). Others include ECG changes (0.4%), musculoskeletal pain (0.2%), abdominal pain (0.2%), renal failure (0.1%) and thrombocytopenia (0.2%), among a few more.
Can I take Conart during pregnancy or while breastfeeding?
Pregnancy Category C. Well-controlled studies in pregnant women have not been done, so its safety in pregnancy has not been firmly established. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Conart?
Too much Bumetanide can cause a sudden and severe loss of water from the body, along with loss of volume and electrolytes. This leads to dehydration and a fall in blood volume, and the circulation can collapse. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Conart?
Store Bumetanide below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Conart?
Some medicines can interact with Bumetanide, for example: Indomethacin, Polymyxin B Sulfate, Digoxin, Benzoic Acid + Salicylic Acid, Ramosetron Hydrochloride, Warfarin Sodium. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Conart?
Conart is a prescription (Rx) medicine. Take it as your doctor advises.