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These brands contain the same active ingredient (Colchicine). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Coluric
Other strengths and forms by Unimed Unihealth Pharmaceuticals Ltd.
Indications & Uses
Pharmacology
An acute attack of gout seems to come from an inflammatory reaction to crystals of monosodium urate. These crystals form in the joint tissue when body fluids carry too much uric acid. The reaction gets worse as more urate crystals build up. White blood cells (leukocytes) move to the spots where the crystals have collected and try to engulf them by phagocytosis. This releases lactic acid and proinflammatory enzymes, which cause the inflammation behind the severe pain, redness and swelling in the affected joint. The lactic acid also lowers the pH locally, and that makes more uric acid deposit in the joint. Colchicine stops leukocytes from taking up uric acid by phagocytosis, and it also directly reduces the amount of lactic acid produced. In this way it breaks the cycle of crystal deposition and inflammation that keeps an acute gout attack going.
Colchicine is absorbed well when taken by mouth. After a single dose on an empty stomach, the mean Cmax is 2.5 ng/mL (range 1.1 to 4.4 ng/mL), reached within 1 to 2 hours. Its mean apparent volume of distribution is about 5 to 8 L/kg. Colchicine binds only weakly to serum protein, 39 ± 5%, and it binds mainly to albumin whatever the concentration. CYP3A4 helps metabolise colchicine into 2-O-demethylcolchicine and 3-O-demethylcolchicine. These metabolites are present in very small amounts, less than 5% of the parent drug in plasma. After multiple oral doses of 0.6 mg twice daily, the mean elimination half-life is 26.6 to 31.2 hours.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Acute gouty arthritis: joint pain and swelling are typically reduced within 12 hours and are usually gone within 24 to 48 hours. An interval of three days between colchicine courses is advised to minimize the possibility of cumulative toxicity. The total amount of colchicine needed to control pain and inflammation during an attack usually ranges from 4 to 8 mg. First dose: 1 to 1.2 mg (two 0.6 mg tablets) at a time, then one 0.6 mg tablet every 2 hours until pain and inflammation are relieved.
For prophylaxis during intercritical periods: severe cases may require two or three 0.6 mg tablets daily. For cases involving more than one attack per year, the usual dose is 0.6 mg daily. In patients who have less than one attack per year, the usual dose is 0.6 mg per day, three or four days a week. To reduce the frequency and severity of attacks, colchicine may be administered continuously.
For prophylaxis against attacks of gout in patients undergoing surgery: in patients with gout, even a minor surgical procedure may bring on an attack. One 0.6 mg tablet three times daily should be given for three days before and three days after surgery.
Side Effects
Colchicine can affect your blood cells. Reported problems include myelosuppression, leukopenia, granulocytopenia, thrombocytopenia, and aplastic anemia. Diarrhea and pain in the throat and voice box (pharyngolaryngeal pain) may also happen.
Cautions & Contraindications
Contraindications
Patients with renal or hepatic impairment should not receive Colchicine together with permeability glycoprotein (P-gp) or strong CYP3A4 inhibitors (e.g., clarithromycin or cyclosporine).
Pregnancy & Breastfeeding
Pregnancy Category C. There have been no adequate, well-controlled studies of colchicine in pregnant women. Colchicine passes into breast milk, so nursing mothers should use it only with caution.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Use in children: gout is rare in children. Colchicine has not been shown to be safe or effective for them, as its safety and effectiveness in pediatric patients have not been established.
Overdose
The exact dose of Colchicine that causes significant toxicity isn't known. Deaths have happened after a dose as low as 7 mg taken over 4 days, but other patients have survived after taking more than 60 mg. One review looked at 150 patients who overdosed on Colchicine. Those who took less than 0.5 mg/kg survived and tended to have milder toxicities, such as gastrointestinal symptoms. Those who took 0.5 to 0.8 mg/kg had more severe reactions, such as myelosuppression.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Colchicine below 30°C and protect it from light and moisture. Always keep the medicine out of reach of children.
Drug Interactions
Common questions about Coluric 0.6 mg
What is Coluric 0.6 mg Tablet?
Coluric 0.6 mg Tablet is a medicine that contains Colchicine. It is made by Unimed Unihealth Pharmaceuticals Ltd. It belongs to the Drugs used in Gout group of medicines.
What is Coluric used for?
Coluric is used for: Fever, Gout.
What are the side effects of Coluric?
Colchicine can affect your blood cells. Reported problems include myelosuppression, leukopenia, granulocytopenia, thrombocytopenia, and aplastic anemia.
Can I take Coluric during pregnancy or while breastfeeding?
Pregnancy Category C. There have been no adequate, well-controlled studies of colchicine in pregnant women. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Coluric?
The exact dose of Colchicine that causes significant toxicity isn't known. Deaths have happened after a dose as low as 7 mg taken over 4 days, but other patients have survived after taking more than 60 mg. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Coluric?
Keep Colchicine below 30°C and protect it from light and moisture. Always keep the medicine out of reach of children.
Can I take other medicines with Coluric?
Some medicines can interact with Colchicine, for example: Clarithromycin, Atorvastatin + Ezetimibe, Febuxostat, Rosuvastatin + Ezetimibe, Mecobalamin, Cisplatin. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Colut by Novatek Pharmaceuticals Ltd. has the same ingredient and strength for ৳5.00 per unit, compared with ৳7.50 for Coluric. Ask your doctor or pharmacist before switching.
Do I need a prescription for Coluric?
Coluric is a prescription (Rx) medicine. Take it as your doctor advises.