Pricing
Prices are indicative MRP and may vary by pharmacy. Trend compares against the last recorded price.
All price changes →Clonate-NN
Rx0.05%+0.5%+2% • Cream
Indications & Uses
Clonate-NN is indicated for:
Pharmacology
Clobetasol Propionate is a very potent corticosteroid. It is prescribed to treat severe inflammatory skin disorders such as eczema and psoriasis that have not responded to weaker corticosteroids. Neomycin Sulphate is an antibiotic of the aminoglycoside type and is used to treat bacterial infections. Nystatin is an antifungal that kills fungi and yeasts by interfering with their cell membranes. The mechanism of topical steroids like Clobetasol, in general, is not well understood. However, Clobetasol Propionate is a highly active corticosteroid with topical anti-inflammatory activity. Its major effect on the skin is a nonspecific anti-inflammatory response, due partly to vasoconstriction and a decrease in collagen synthesis. Neomycin binds to the ribosomal 30s and 50s subunits of susceptible bacteria and inhibits protein synthesis. It also causes the genetic codes of the mRNA template to be misread, so that incorrect amino acids are incorporated into the growing polypeptide chain. Nystatin acts by binding to sterols in the fungal cell membrane, changing its permeability and allowing intracellular components to leak out.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults: Apply a thin layer to the affected area once or twice a day until the condition improves. For very stubborn lesions, particularly those with thickened, hardened skin (hyperkeratosis), the anti-inflammatory effect can be boosted, if needed, by covering the treated area with polythene. Treatment should not continue beyond 7 days without a doctor's supervision. If a longer course is needed, it is advised not to continue treatment beyond 4 weeks without having the patient's condition reassessed.
Elderly: This preparation is suitable for elderly patients. Caution is advised where kidney function is reduced, as significant systemic absorption of Neomycin Sulphate may occur.
Children: This preparation is suitable for children aged 2 years and above, at the same dose as adults. Because very young children may absorb more of the medicine, this cream/ointment is not recommended for neonates and infants under 2 years of age.
Side Effects
As with other topical corticosteroids, using large amounts for a long time or treating wide areas of skin can let enough of the medicine absorb into the body to cause features of hypercortisolism. This is more likely in infants and children, and when occlusive dressings are used. Prolonged, intensive treatment with highly active corticosteroid preparations may cause local atrophic changes in the skin, such as thinning, striae, and dilatation of the superficial blood vessels, particularly when occlusive dressings are used or when skin folds are involved. There are also reports of pigmentation changes and hypertrichosis with topical steroids.
Cautions & Contraindications
Warnings & Precautions
Long-term, continuous use of this medicine on the skin should be avoided wherever possible, especially in infants and children, since it can suppress adrenal gland function fairly easily, even when the treated area isn't covered or bandaged. If it is used on the eyelids, care must be taken to keep it from getting into the eye, as this could lead to glaucoma. Should it accidentally get into the eye, rinse the affected eye thoroughly with plenty of water.
Contraindications
This medication should not be used by people with rosacea, acne vulgaris, or perioral dermatitis, or by those with a primary cutaneous viral infection such as herpes simplex or chicken pox. It should also be avoided by anyone who is hypersensitive to any component of the preparation.
Pregnancy & Breastfeeding
There is limited information about the effect of topically applied Neomycin during pregnancy and lactation. However, Neomycin present in the mother's blood can cross the placenta, and this may pose a theoretical risk of toxicity to the developing baby. For this reason, the preparation is not recommended for use during pregnancy or lactation. The safety of Clobetasol Propionate has not been established in breastfeeding mothers.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
It's very unlikely that anyone would take an acute overdose of Clobetasol Propionate + Neomycin Sulphate + Nystatin, and no overdose-related problem has been reported so far. With long-term overdose or misuse, though, features of hypercortisolism may appear. If that happens, the topical steroid should be stopped gradually.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep this medicine at a temperature below 25°C. Don't let it freeze. Always keep it where children can't reach it.
Drug Interactions
Common questions about Clonate-NN 0.05%+0.5%+2%
What is Clonate-NN 0.05%+0.5%+2% Cream?
Clonate-NN 0.05%+0.5%+2% Cream is a medicine that contains Clobetasol Propionate + Neomycin Sulphate + Nystatin. It is made by Kemiko Pharmaceuticals Ltd. It belongs to the Clobetasol / Clobetasone & Combined Preparations group of medicines.
What is Clonate-NN used for?
Clonate-NN is used for: Bacterial Infection, Fungal Infection, Psoriasis, Inflammation.
What are the side effects of Clonate-NN?
As with other topical corticosteroids, using large amounts for a long time or treating wide areas of skin can let enough of the medicine absorb into the body to cause features of hypercortisolism. This is more likely in infants and children, and when occlusive dressings are used.
Can I take Clonate-NN during pregnancy or while breastfeeding?
There is limited information about the effect of topically applied Neomycin during pregnancy and lactation. However, Neomycin present in the mother's blood can cross the placenta, and this may pose a theoretical risk of toxicity to the developing baby. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Clonate-NN?
It's very unlikely that anyone would take an acute overdose of Clobetasol Propionate + Neomycin Sulphate + Nystatin, and no overdose-related problem has been reported so far. With long-term overdose or misuse, though, features of hypercortisolism may appear. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Clonate-NN?
Keep this medicine at a temperature below 25°C. Don't let it freeze.
Can I take other medicines with Clonate-NN?
Some medicines can interact with Clobetasol Propionate + Neomycin Sulphate + Nystatin, for example: Nystatin, Neomycin Sulphate, Clobetasol Propionate. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Clonate-NN?
Clonate-NN is a prescription (Rx) medicine. Take it as your doctor advises.