Pricing
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All price changes →Indications & Uses
Clasrin is indicated for:
Pharmacology
Clascoterone (cortexolone 17 α-propionate) is a new androgen receptor antagonist. It binds to androgen receptors with high affinity. By competing with androgens for the receptor, clascoterone blocks the androgen receptor signalling cascades that promote acne pathogenesis, such as sebaceous gland proliferation, excess sebum production and inflammatory pathways.
Acne is a multifactorial skin condition. It is marked by excess sebum production, epithelial hyperkeratinization, proliferation of the skin commensal bacteria, and inflammation. Testosterone and dihydrotestosterone (DHT) are the natural ligands, and they circulate in the body and are also made locally. They are causative factors in both males and females. When DHT binds, the DHT-androgen receptor complex dimerizes and moves into the nucleus. There it promotes the transcription of genes involved in acne pathogenesis, including proliferation and differentiation of sebocytes, excess sebum production, and inflammatory cytokine production. Clascoterone is a potent antagonist at androgen receptors (ARs) and competes with androgens for binding to the receptor. In this way it inhibits the downstream signalling of ARs that promotes acne.
Androgenetic alopecia is also an androgen-dependent and highly genetic condition. DHT binds to ARs expressed on dermal papilla cells (DPC) in the scalp and induces AR-mediated transcription of genes that contribute to androgenic alopecia. Clascoterone blocks the interaction between DHT and ARs, and so it inhibits AR-regulated transcription and DHT-induced IL-6 synthesis.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Clean the affected area gently, then apply a thin, even layer of Clascoterone cream (about 1 gm) to it twice a day, once in the morning and once in the evening. Try not to let the cream get into your eyes, mouth or other mucous membranes by accident. If it does, rinse the area thoroughly with water, or do as the doctor directs.
Use in children and adolescents: the safety and effectiveness of Clascoterone cream for treating acne vulgaris on the skin have not been established in patients under 12 years of age.
Side Effects
Side-effect information is not available for this brand yet.
Cautions & Contraindications
Warnings & Precautions
Local irritation: Clascoterone cream can cause itching, burning, redness of the skin or peeling. If any of these happen, stop using the cream or apply it less often. Hypothalamic-pituitary-adrenal (HPA) axis suppression may occur during or after treatment with Clascoterone. Children may be more susceptible to systemic toxicity. Hyperkalemia: some people in the clinical trials had raised potassium levels.
Contraindications
No contraindication data is available for clascoterone cream.
Pregnancy & Breastfeeding
There's no data on the use of clascoterone cream in pregnant women, so its possible risk of major birth defects, miscarriage, or other harmful outcomes for the mother or the baby can't be judged. There's also no data on whether clascoterone or its metabolite passes into human milk, or on what it does to milk production or to a breastfed infant.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
No case of overdose with Clascoterone has been reported so far.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
For indications and dosage, please see the enclosed leaflet. Clascoterone should be dispensed only on the prescription of a registered physician. Protect it from light and keep it in a dry place. Before dispensing, store it at 2° to 8°C. Once it is in use, keep it at room temperature, 20° to 25°C, for 90 days. Keep it out of the reach of children.
Common questions about Clasrin 1%
What is Clasrin 1% Cream?
Clasrin 1% Cream is a medicine that contains Clascoterone. It is made by The ACME Laboratories Ltd. It belongs to the Acne treatment preparations group of medicines.
What is Clasrin used for?
Clasrin is used for: Acne Vulgaris.
Can I take Clasrin during pregnancy or while breastfeeding?
There's no data on the use of clascoterone cream in pregnant women, so its possible risk of major birth defects, miscarriage, or other harmful outcomes for the mother or the baby can't be judged. There's also no data on whether clascoterone or its metabolite passes into human milk, or on what it does to milk production or to a breastfed infant. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Clasrin?
No case of overdose with Clascoterone has been reported so far. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Clasrin?
For indications and dosage, please see the enclosed leaflet. Clascoterone should be dispensed only on the prescription of a registered physician.
Do I need a prescription for Clasrin?
Clasrin is a prescription (Rx) medicine. Take it as your doctor advises.