Pricing
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All price changes →Indications & Uses
Citicoline Sodium (Vasoactin) is used in cerebrovascular disease, for example ischemia due to stroke. In this condition it speeds up the recovery of consciousness and helps the patient overcome motor deficit. When treatment starts within the first 24 hours after onset in patients with moderate to severe stroke, the probability of complete recovery in 3 months is higher. It is also used for cerebral insufficiency (such as dizziness, memory loss, poor concentration and disorientation) due to head trauma or brain injury, and for cognitive dysfunction due to degenerative disease (Alzheimer's disease). In Parkinson's disease, Citicoline Sodium has been shown to be effective as co-therapy.
Pharmacology
Citicoline is a substance the body makes naturally, and it is an essential intermediate in building the structural phospholipids of the cell membrane. When Citicoline is taken by mouth, it is broken down into choline and cytidine. These pass into the systemic circulation, cross the blood-brain barrier and join together again to form Citicoline inside the central nervous system.
Once there, Citicoline activates the biosynthesis of structural phospholipids in the neuronal membrane. It also promotes rapid repair of injured cell surface and mitochondrial membranes, and it raises the level of several neurotransmitters, such as acetylcholine and dopamine. Citicoline has neuroprotective effects in situations of hypoxia and ischemia. In animal models of the aging brain, it also improved learning and memory performance. By inhibiting the activation of Phospholipase A2, Citicoline helps prevent apoptotic and necrotic cell death.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Citicoline Sodium is taken by mouth for stroke caused by a clot (ischemic stroke) at 500 to 2000 mg of Citicoline per day, and the first dose should be given within 24 hours of the stroke. For decline in thinking skills after a stroke, the dose is 1000 to 2000 mg of Citicoline per day. In chronic cerebrovascular disease, which is ongoing disease of the blood vessels that serve the brain, the dose is 1000 mg daily, divided into smaller doses and taken with or between meals.
The injection is given 1 to 2 times daily, and the dose is adjusted according to how severe the condition is. It can go in through the intramuscular (IM) route or the intravenous (IV) route, and an IV injection is given over 3 to 5 minutes.
For older patients, no dose adjustment is required and the usual dose can be given.
Side Effects
Now and then, Citicoline Sodium can stimulate the parasympathetic system. It may also cause a brief, mild drop in blood pressure.
Cautions & Contraindications
Warnings & Precautions
Citicoline Sodium can increase dizziness or drowsiness, so patients are strongly advised not to operate any kind of machinery during treatment. It may also cause hypotension. If needed, this fall in blood pressure can be treated with corticosteroids or a sympathomimetic. In persistent intracranial hemorrhage, very slow administration is recommended, at 30 drops/minutes. Larger doses could increase the cerebral blood flow. Patients should not drink alcohol while taking Citicoline Sodium.
Contraindications
Citicoline Sodium must not be given to patients who have hypertonia of the parasympathetic nervous system.
Pregnancy & Breastfeeding
No adequate, well-controlled studies of Citicoline have been done in pregnancy or during breastfeeding. So Citicoline should be used in pregnancy and lactation only if the likely benefit justifies the possible risk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Citicoline Sodium below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Citivas 500 mg
What is Citivas 500 mg Tablet?
Citivas 500 mg Tablet is a medicine that contains Citicoline Sodium. It is made by Square Pharmaceuticals PLC, Pabna. It belongs to the CNS stimulant drugs group of medicines.
What is Citivas used for?
Citicoline Sodium (Vasoactin) is used in cerebrovascular disease, for example ischemia due to stroke. In this condition it speeds up the recovery of consciousness and helps the patient overcome motor deficit.
What are the side effects of Citivas?
Now and then, Citicoline Sodium can stimulate the parasympathetic system. It may also cause a brief, mild drop in blood pressure.
Can I take Citivas during pregnancy or while breastfeeding?
No adequate, well-controlled studies of Citicoline have been done in pregnancy or during breastfeeding. So Citicoline should be used in pregnancy and lactation only if the likely benefit justifies the possible risk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Citivas?
Store Citicoline Sodium below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Citivas?
Some medicines can interact with Citicoline Sodium, for example: Levodopa, Entacapone. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Citivas is already among the lowest-priced brands of Citicoline Sodium at this strength.
Do I need a prescription for Citivas?
Citivas is a prescription (Rx) medicine. Take it as your doctor advises.