Pricing
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All price changes →Indications & Uses
Cilanem is indicated for:
Pharmacology
Imipenem + Cilastatin is a combined preparation. Imipenem is a penem antibacterial. Cilastatin sodium is a renal dehydropeptidase inhibitor, and it limits the breakdown of imipenem in the kidneys.
Imipenem kills bacteria by blocking the synthesis of their cell wall. It binds most strongly to penicillin binding proteins (PBPs) 1A, 1B, 2, 4, 5 and 6 of Escherichia coli, and to PBPs 1A, 1B, 2, 4 and 5 of Pseudomonas aeruginosa. The lethal effect is linked to binding to PBP 2 and PBP 1B.
Imipenem stays highly stable in the presence of beta-lactamases, both penicillinases and cephalosporinases, whether they are produced by Gram-negative or Gram-positive bacteria. It is also a potent inhibitor of betalactamases from certain Gram-negative bacteria that are naturally resistant to most beta-lactam antibacterials, for example Pseudomonas aeruginosa, Serratia spp. and Enterobacter spp.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The adult dosage of Imipenem + Cilastatin should be based on suspected or confirmed pathogen susceptibility. For adult patients with normal renal function (creatinine clearance of greater than or equal to 90 mL/min), the recommended dosage regimens are 500 mg every 6 hours OR 1000 mg every 8 hours OR 1000 mg every 6 hours. The dose must be reduced for a patient with a creatinine clearance of less than 90 mL/min. Patients with creatinine clearances of less than 15 mL/min should not receive this combination unless hemodialysis is instituted within 48 hours. Reconstitute the vial with an appropriate diluent, then dilute the reconstituted suspension with an appropriate infusion solution before giving it by intravenous infusion.
The recommended pediatric dosage for non-CNS infections depends on age. For children greater than or equal to 3 months of age, it is 15 to 25 mg/kg every 6 hours. For those less than or equal to 3 months of age (greater than or equal to 1,500 g body weight), the dosage is 25 mg/kg every 6 hours at 4 weeks to 3 months of age, 25 mg/kg every 8 hours at 1 to 4 weeks of age, and 25 mg/kg every 12 hours at less than 1 week of age.
Give doses of less than or equal to 500 mg by intravenous infusion over 20 to 30 minutes. Doses greater than 500 mg should be given by intravenous infusion over 40 to 60 minutes. The maximum total daily dosage should not exceed 4g/day.
Side Effects
Phlebitis, nausea, diarrhea, vomiting, rash, pruritus, urticaria, pain at the injection site, erythema at the injection site, vein induration, fever, hypotension, seizures, dizziness, somnolence.
Cautions & Contraindications
Warnings & Precautions
Hypersensitivity reactions Serious and sometimes fatal hypersensitivity (anaphylactic) reactions have been reported in patients treated with beta-lactams. If an allergic reaction to Imipenem + Cilastatin occurs, stop the medicine immediately. Seizure potential Seizures and other CNS adverse reactions, such as confusional states and myoclonic activity, have been reported during treatment with Imipenem + Cilastatin. If focal tremors, myoclonus or seizures occur, the patient should be evaluated neurologically and started on anticonvulsant therapy if this has not already been done. The dose of Imipenem + Cilastatin should also be re-examined, to decide whether it should be reduced or the antibacterial drug stopped.
Pregnancy & Breastfeeding
Imipenem + Cilastatin is Pregnancy Category C. There are no adequate and well-controlled studies of this combination in pregnant women, so it should be used during pregnancy only if the potential benefit justifies the potential risk to the mother and fetus.
It is not known whether Imipenem-Cilastatin sodium passes into human milk. Many drugs do pass into breast milk, so caution should be exercised when this combination is given to a nursing woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Imipenem + Cilastatin at or below 25° C. Protect it from light and from damp places. Keep it out of reach of children.
Drug Interactions
Common questions about Cilanem 500 mg+500 mg
What is Cilanem 500 mg+500 mg IV Injection?
Cilanem 500 mg+500 mg IV Injection is a medicine that contains Imipenem + Cilastatin. It is made by Eskayef Pharmaceuticals Ltd. It belongs to the Other beta-lactam antibiotics group of medicines.
What is Cilanem used for?
Cilanem is used for: Bacterial Infection, Respiratory Tract Infection, Skin and Soft Tissue Infection, Sepsis.
What are the side effects of Cilanem?
Phlebitis, nausea, diarrhea, vomiting, rash, pruritus, urticaria, pain at the injection site, erythema at the injection site, vein induration, fever, hypotension, seizures, dizziness, somnolence.
Can I take Cilanem during pregnancy or while breastfeeding?
Imipenem + Cilastatin is Pregnancy Category C. There are no adequate and well-controlled studies of this combination in pregnant women, so it should be used during pregnancy only if the potential benefit justifies the potential risk to the mother and fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Cilanem?
Keep Imipenem + Cilastatin at or below 25° C. Protect it from light and from damp places.
Can I take other medicines with Cilanem?
Some medicines can interact with Imipenem + Cilastatin, for example: Ganciclovir. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Cilanem is already among the lowest-priced brands of Imipenem + Cilastatin at this strength.
Do I need a prescription for Cilanem?
Cilanem is a prescription (Rx) medicine. Take it as your doctor advises.