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Other brands with the same active ingredient
These brands contain the same active ingredient (Cenobamate). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Cenomate 500 is indicated for:
Pharmacology
Cenobamate is a positive modulator of GABA-A, and it also inhibits voltage-gated sodium channels. When these sodium channels are inhibited, the threshold for generating action potentials goes up and fewer action potentials are produced. The two mechanisms work in a complementary way, and this may contribute to its superior anti-seizure activity.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Cenobamate can be taken with or without food, or as the doctor advises. The dose for partial-onset seizures in adults starts low and is raised step by step.
Initial dosage
For weeks 1 and 2, the dose is 12.5 mg once daily.
Titration regimen
For weeks 3 and 4, the dose is 25 mg once daily. Weeks 5 and 6 call for 50 mg once daily. At weeks 7 and 8 it goes up to 100 mg once daily, and for weeks 9 and 10 it is 150 mg once daily.
Maintenance dosage
From week 11 onwards, the dose is 200 mg once daily.
Maximum dosage
If needed, based on clinical response and tolerability, the dose may be raised above 200 mg. The increase is 50 mg once daily every two weeks, up to 400 mg once daily.
Side Effects
Common side effects of Cenobamate include somnolence, fatigue, dizziness or feeling sleepy, nausea, constipation, double vision, decreased appetite, diarrhea and weakness. A very serious allergic reaction to Cenobamate is rare.
Cautions & Contraindications
Warnings & Precautions
Cenobamate can cause multiorgan hypersensitivity reaction, QT shortening and suicidal thoughts. Somnolence and fatigue should be re-evaluated from time to time. Patients on Cenobamate therapy are advised not to drive or operate machinery. The medicine should be withdrawn gradually, to reduce the chance of increased seizure frequency. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) / Multi-Organ Hypersensitivity: stop the medicine if no other cause is found. QT Shortening: take care when giving Cenobamate together with other drugs that shorten the QT interval. Suicidal Behavior and Ideation: monitor patients for suicidal behavior and ideation. Neurological Adverse Reactions: watch for somnolence and fatigue. Advise patients not to drive or operate machinery until they have gained enough experience on Cenobamate. Using it with other CNS depressants or with alcohol may have additive effects. Withdrawal of Antiepileptic Drugs: Cenobamate should be withdrawn gradually, to reduce the chance of increased seizure frequency.
Contraindications
Cenobamate must not be given to anyone with a known allergy (hypersensitivity) to cenobamate or to any of the other ingredients in the medicine. It must also not be given to people with familial short QT syndrome.
Pregnancy & Breastfeeding
There are no adequate and well-controlled studies of Cenobamate in pregnant women. Even so, it may cause harm to the unborn baby when a pregnant woman takes it, so it should be used in pregnancy only if the likely benefit justifies the possible risk to the baby. As for breastfeeding, there are no data on whether Cenobamate passes into human milk. Nor is anything known about its effects on a breastfed infant or on milk production.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric use: Cenobamate hasn't been shown to be safe or effective in children under 18 years.
Geriatric use: Start at the low end of the dosing range.
Renal impairment: Use Cenobamate with caution in patients with mild to moderate (creatinine clearance 30 to <90 ml/min) or severe (creatinine clearance <30 ml/min) renal impairment, and the doctor may consider reducing the target dose. The maximum recommended dose for patients with mild, moderate or severe renal impairment is 300 mg/day. Cenobamate should not be used in patients with end-stage renal disease, or in patients undergoing hemodialysis.
Hepatic impairment: Use Cenobamate with caution in patients with mild to moderate hepatic impairment. A lower maximum dose and further dose reduction may be considered. Cenobamate is not recommended in patients with severe hepatic impairment.
Overdose
If someone takes too much Cenobamate, the medicine should be stopped. The person then gets general supportive treatment until the signs of toxicity have eased or cleared.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Cenobamate at a temperature not above 30 degree C. Keep it away from light, and keep it out of the reach of children.
Drug Interactions
Common questions about Cenomate 500 50 mg
What is Cenomate 500 50 mg Tablet?
Cenomate 500 50 mg Tablet is a medicine that contains Cenobamate. It is made by Everest Pharmaceuticals Ltd. It belongs to the Adjunct anti-epileptic drugs group of medicines.
What is Cenomate 500 used for?
Cenomate 500 is used for: Epilepsy.
What are the side effects of Cenomate 500?
Common side effects of Cenobamate include somnolence, fatigue, dizziness or feeling sleepy, nausea, constipation, double vision, decreased appetite, diarrhea and weakness. A very serious allergic reaction to Cenobamate is rare.
Can I take Cenomate 500 during pregnancy or while breastfeeding?
There are no adequate and well-controlled studies of Cenobamate in pregnant women. Even so, it may cause harm to the unborn baby when a pregnant woman takes it, so it should be used in pregnancy only if the likely benefit justifies the possible risk to the baby. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Cenomate 500?
If someone takes too much Cenobamate, the medicine should be stopped. The person then gets general supportive treatment until the signs of toxicity have eased or cleared. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Cenomate 500?
Store Cenobamate at a temperature not above 30 degree C. Keep it away from light, and keep it out of the reach of children.
Can I take other medicines with Cenomate 500?
Some medicines can interact with Cenobamate, for example: Lamotrigine, Carbamazepine, Clobazam, Phenytoin, Phenobarbital. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Cenomate 500?
Cenomate 500 is a prescription (Rx) medicine. Take it as your doctor advises.