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Other brands with the same active ingredient
These brands contain the same active ingredient (Cefditoren). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Cefdiren 400 is indicated for:
Pharmacology
Cefditoren is delivered as Cefditoren Pivoxil, a broad-spectrum third-generation cephalosporin antibiotic. It is a prodrug, hydrolyzed by esterases during absorption, so the active form, Cefditoren, is what circulates in the blood. Cefditoren acts against both gram-positive and gram-negative organisms. Its bactericidal effect comes from blocking cell wall synthesis, achieved by binding to penicillin-binding proteins (PBPs). Cefditoren also holds up well against several ß-lactamases, including penicillinases and certain cephalosporinases.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Cefditoren should be taken after meals. For Community-Acquired Pneumonia, the recommended dose is 400 mg twice daily for 14 days. For Acute Exacerbation of Chronic Bronchitis, it is 400 mg twice daily for 10 days. For Pharyngotonsillitis and Acute Sinusitis, the dose is 200 mg twice daily for 10 days. For Uncomplicated Skin and Soft Structure Infections, it is also 200 mg twice daily for 10 days.
Side Effects
Cefdiren commonly causes diarrhea, nausea, headache, abdominal pain, vaginal moniliasis, dyspepsia, vomiting, abnormal dreams, allergic reaction, anorexia, constipation, dizziness, dry mouth and fever.
Cautions & Contraindications
Warnings & Precautions
Cefdiren is not recommended for prolonged antibiotic treatment, since other pivalate-containing compounds have caused clinical signs of carnitine deficiency when used over a period of months. Prescribing Cefdiren without a proven or strongly suspected bacterial infection, or without a prophylactic indication, is unlikely to benefit the patient and raises the risk of developing drug-resistant bacteria.
Contraindications
Cefditoren should not be used in patients who are allergic to cephalosporin antibiotics or to any of its ingredients. It also contains sodium caseinate, a milk protein, so patients with a genuine milk protein allergy (as opposed to lactose intolerance) should avoid taking Cefditoren.
Pregnancy & Breastfeeding
Pregnancy category B. No adequate, well controlled studies have been conducted in pregnant women, so Cefditoren should be used during pregnancy only if clearly needed. Animal studies show that Cefditoren passes into breast milk, so caution should be exercised when giving it to nursing mothers.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Children: Cefditoren is not recommended for children under 12 years of age. Its safety and efficacy in Cefditoren tablets for this age group, including any effects of altered carnitine concentration, have not been established.
Geriatric patients: No dose adjustment is needed for geriatric patients whose kidney function is normal for their age.
Patients with renal insufficiency: No dose adjustment is needed for mild renal impairment (ClCr: 50-80 mL/min/1.73 m2). In moderate renal impairment (ClCr: 30-49 mL/min/1.73 m2), no more than 200 mg BID should be given. In severe renal impairment (ClCr: <30 mL/min/1.73 m2), the recommended dose is 200 mg QD. The right dose for patients with end-stage renal disease has not been determined.
Patients with hepatic disease: No dose adjustment is needed for mild or moderate hepatic impairment.
Overdose
No information is available on Cefditoren overdose in humans. With other ß-lactam antibiotics, though, overdose has caused nausea, vomiting, epigastric distress, diarrhea and convulsions. Hemodialysis may help remove Cefditoren from the body, particularly if kidney function is compromised.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Cefditoren below 25°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Cefdiren 400 400 mg
What is Cefdiren 400 400 mg Tablet?
Cefdiren 400 400 mg Tablet is a medicine that contains Cefditoren. It is made by Ibn Sina Pharmaceutical Ind. Ltd. It belongs to the Third generation cephalosporins group of medicines.
What is Cefdiren 400 used for?
Cefdiren 400 is used for: Chronic Obstructive Pulmonary Disease, Pneumonia, Bronchitis, Pharyngitis, Tonsillitis.
What are the side effects of Cefdiren 400?
Cefdiren commonly causes diarrhea, nausea, headache, abdominal pain, vaginal moniliasis, dyspepsia, vomiting, abnormal dreams, allergic reaction, anorexia, constipation, dizziness, dry mouth and fever.
Can I take Cefdiren 400 during pregnancy or while breastfeeding?
Pregnancy category B. No adequate, well controlled studies have been conducted in pregnant women, so Cefditoren should be used during pregnancy only if clearly needed. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Cefdiren 400?
No information is available on Cefditoren overdose in humans. With other ß-lactam antibiotics, though, overdose has caused nausea, vomiting, epigastric distress, diarrhea and convulsions. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Cefdiren 400?
Store Cefditoren below 25°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Cefdiren 400?
Some medicines can interact with Cefditoren, for example: Famotidine, Estradiol. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Cefdiren 400?
Cefdiren 400 is a prescription (Rx) medicine. Take it as your doctor advises.