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Indications & Uses
Caspogin is indicated for:
Pharmacology
Caspofungin is an antifungal medicine and belongs to a newer class called the echinocandins. It is used to treat Aspergillus and Candida infections, and it works by blocking the building of the fungal cell wall. Antifungals in this class stop the synthesis of glucan in the cell wall, probably through the enzyme 1,3-beta glucan synthase.
Resistance can develop. However, in vitro resistance to caspofungin by Aspergillus species has not been studied.
Caspofungin inhibits the synthesis of beta-(1,3)-D-glucan, an essential component of the cell wall of Aspergillus species and Candida species. This substance is not present in mammalian cells. The primary target is beta-(1,3)-glucan synthase.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Important administration instructions for all patients: give caspofungin acetate by slow intravenous (IV) infusion over approximately 1 hour. Don't give it as an intravenous (IV) bolus. Don't mix caspofungin acetate for injection with other medicines, and don't co-infuse them. Don't use diluents that contain dextrose (α-D-glucose).
Dosage in adults (18 years of age and older): give a single 70 mg loading dose on Day 1, then 50 mg once daily, for all indications except esophageal candidiasis. For esophageal candidiasis, use 50 mg once daily with no loading dose.
Dosage in pediatric patients (3 months to 17 years of age): base the dose on the patient's body surface area. For all indications, give a single 70 mg/m 2 loading dose on Day 1, then 50 mg/m 2 once daily after that. Neither the loading dose nor the daily maintenance dose should go above 70 mg, regardless of the patient's calculated dose.
Dosage adjustments in patients with hepatic impairment: reduce the dosage for adult patients with moderate hepatic impairment (35 mg once daily, with a 70 mg loading dose on Day 1 where appropriate).
Dosage adjustments in patients receiving concomitant inducers of hepatic CYP enzymes: use a 70 mg once daily dose for adult patients on rifampin. Consider raising the dose to 70 mg once daily for adult patients on nevirapine, efavirenz, carbamazepine, dexamethasone, or phenytoin. Pediatric patients receiving these same concomitant medicines may also need an increase to 70 mg/m 2 once daily (maximum daily dose not to exceed 70 mg).
Side Effects
In adults taking Caspofungin Acetate, the most common side effects (seen in 10% or more of people) are diarrhea, pyrexia, increased ALT/AST, increased blood alkaline phosphatase, and decreased blood potassium. In pediatric patients, the most common side effects (again in 10% or more) are pyrexia, diarrhea, rash, increased ALT/AST, decreased blood potassium, hypotension, and chills.
Cautions & Contraindications
Warnings & Precautions
Hypersensitivity Anaphylaxis has been reported with caspofungin. If it happens, stop caspofungin and give appropriate treatment. Reactions that may be caused by histamine have also been reported, including rash, facial swelling, angioedema, pruritus, a sensation of warmth or bronchospasm. These may need caspofungin to be stopped and/or appropriate treatment to be given. Hepatic Effects Caspofungin can cause abnormalities in liver enzymes. Isolated cases of hepatic dysfunction, hepatitis or hepatic failure have been reported. If a patient develops abnormal liver enzymes, monitor them for signs of worsening hepatic function and weigh the risk and benefit of continuing caspofungin. Abnormal Liver Enzymes during Concomitant use with Cyclosporine Limit use to patients for whom the potential benefit outweighs the potential risk. Monitor patients who develop abnormal liver function tests (LFTs) during concomitant use with caspofungin.
Contraindications
Don't give Caspofungin to anyone who is known to be allergic to it or to any other component of the product.
Pregnancy & Breastfeeding
Caspofungin is Pregnancy Category C. There are no adequate and well-controlled studies of its use in pregnant women. In animal studies it caused embryofetal toxicity, which included increased resorptions, increased peri-implantation loss and incomplete ossification at multiple fetal sites. So caspofungin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
It is not known whether caspofungin is present in human milk. It was found in the milk of lactating rats that had been given the drug. Many drugs pass into human milk, so caution should be exercised when caspofungin is given to a nursing woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep the lyophilized Caspofungin Acetate vials at 20° to 25°C.
Drug Interactions
Common questions about Caspogin 50 mg
What is Caspogin 50 mg IV Infusion?
Caspogin 50 mg IV Infusion is a medicine that contains Caspofungin Acetate. It is made by Healthcare Pharmaceuticals Ltd. It belongs to the Other Antifungal preparations group of medicines.
What is Caspogin used for?
Caspogin is used for: Fungal Infection.
What are the side effects of Caspogin?
In adults taking Caspofungin Acetate, the most common side effects (seen in 10% or more of people) are diarrhea, pyrexia, increased ALT/AST, increased blood alkaline phosphatase, and decreased blood potassium. In pediatric patients, the most common side effects (again in 10% or more) are pyrexia, diarrhea, rash, increased ALT/AST, decreased blood potassium, hypotension, and chills.
Can I take Caspogin during pregnancy or while breastfeeding?
Caspofungin is Pregnancy Category C. There are no adequate and well-controlled studies of its use in pregnant women. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Caspogin?
Keep the lyophilized Caspofungin Acetate vials at 20° to 25°C.
Can I take other medicines with Caspogin?
Some medicines can interact with Caspofungin Acetate, for example: Cyclosporine, Tacrolimus, Rifampicin. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Caspogin?
Caspogin is a prescription (Rx) medicine. Take it as your doctor advises.