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These brands contain the same active ingredient (Diltiazem Hydrochloride). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Cardizem SR
Other strengths and forms by Drug International Unani Ltd.
Indications & Uses
Cardizem SR is indicated for:
Pharmacology
Diltiazem hydrochloride is a calcium channel antagonist. It works as a peripheral and coronary vasodilator and has some negative inotropic activity. Diltiazem inhibits cardiac conduction, particularly at the sino-atrial and atrioventricular nodes. It has the following actions.
Antianginal: it directly dilates the coronary arteries and arterioles, improving oxygen supply to the heart muscle tissue. Dilatation of the peripheral blood vessels also lowers systemic pressure on the cardiac "after load," which lessens stress on the heart and reduces its oxygen requirements.
Antiarrhythmic: by inhibiting the influx of calcium ions into cardiac tissue, it slows electrophysiological activity through the S-A and A-V nodes, without affecting accessory bypass conduction or altering normal atrial action potential or intraventricular conduction.
Antihypertensive: it reduces peripheral vascular resistance through vasodilatation.
More than 90% of an oral dose is rapidly absorbed, and protein binding is very high. Peak plasma concentration is reached within 30 to 60 minutes. Diltiazem is metabolised in the liver, and 60% of it is excreted through bile.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Film-coated tablets: The usual dose of diltiazem hydrochloride film-coated tablets is 60 mg three times daily. However, response varies and dosage requirements can differ significantly between individual patients. If necessary, the total daily dose, given in divided doses, may be increased to 180 to 300 mg per day. Treatment may be started at 30 mg four times daily, increasing at intervals of 1 to 2 days until the best response is achieved. Higher doses of up to 480 mg per day have been used with benefit in some patients, especially in unstable angina.
Elderly patients and patients with impaired liver or kidney function: The recommended starting dose is 60 mg twice daily. Heart rate should be measured regularly, and the dose should not be increased if the heart rate falls below 50 beats per minute.
Sustained-release formulation: For mild to moderate hypertension, the initial dose is 90 mg or 120 mg twice daily (once daily in the elderly); up to 360 mg daily may be required (up to 240 mg daily in the elderly). For angina, the initial dose is 90 mg or 120 mg twice daily in divided doses, as may be required (up to 240 mg daily in the elderly).
Side Effects
Reported side effects include bradycardia, sino-atrial block, atrioventricular block, hypertension, malaise, headache, hot flushes, GIT disturbances, oedema, hepatitis and depression.
Cautions & Contraindications
Contraindications
Diltiazem Hydrochloride sustained-release tablets should not be used in patients who are known to be allergic to the drug, or who have sick sinus syndrome, second- or third-degree AV block, severe hypertension, or acute myocardial infarction with pulmonary congestion confirmed on X-ray.
Pregnancy & Breastfeeding
Diltiazem hasn't been thoroughly studied in pregnant women, so there's no solid evidence on its safety in pregnancy. For this reason, it should only be used during pregnancy if the expected benefit to the mother clearly outweighs any possible risk to the unborn baby.
Diltiazem also passes into breast milk, so breastfeeding is not recommended for mothers taking this medicine. If treatment with diltiazem is needed while a mother is breastfeeding, an alternative way of feeding the infant should be arranged instead.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Diltiazem Hydrochloride below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Cardizem SR 90 mg
What is Cardizem SR 90 mg Tablet (Sustained Release)?
Cardizem SR 90 mg Tablet (Sustained Release) is a medicine that contains Diltiazem Hydrochloride. It is made by Drug International Unani Ltd. It belongs to the Calcium-channel blockers group of medicines.
What is Cardizem SR used for?
Cardizem SR is used for: Hypertension, Angina Pectoris, Myocardial Infarction, Migraine.
What are the side effects of Cardizem SR?
Reported side effects include bradycardia, sino-atrial block, atrioventricular block, hypertension, malaise, headache, hot flushes, GIT disturbances, oedema, hepatitis and depression.
Can I take Cardizem SR during pregnancy or while breastfeeding?
Diltiazem hasn't been thoroughly studied in pregnant women, so there's no solid evidence on its safety in pregnancy. For this reason, it should only be used during pregnancy if the expected benefit to the mother clearly outweighs any possible risk to the unborn baby. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Cardizem SR?
Store Diltiazem Hydrochloride below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Cardizem SR?
Some medicines can interact with Diltiazem Hydrochloride, for example: Bisoprolol Fumarate + Amlodipine Besilate, Rivaroxaban, Olaparib, Venetoclax, Fentanyl Citrate, Domperidone Maleate. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Dilti SR by Edruc Ltd. has the same ingredient and strength for ৳3.00 per unit, compared with ৳6.05 for Cardizem SR. Ask your doctor or pharmacist before switching.
Do I need a prescription for Cardizem SR?
Cardizem SR is a prescription (Rx) medicine. Take it as your doctor advises.