Pricing
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All price changes →Indications & Uses
Cardiron is indicated for:
Pharmacology
Amiodarone Hydrochloride is used to correct abnormal heart rhythms. It is considered a "broad-spectrum" antiarrhythmic medicine, meaning it works through several electrical effects on the heart rather than just one. Its most important actions include: delaying the rate at which the heart's electrical system "recharges" after each heartbeat (repolarisation); prolonging the phase in which the heart's muscle cells are electrically stimulated (the action potential); slowing the speed at which electrical impulses travel through the heart's conduction system; reducing the rate at which the heart's natural pacemaker fires impulses; and slowing conduction through extra, specialised electrical pathways (accessory pathways) that may exist in the heart.
Besides its antiarrhythmic action, Amiodarone also relaxes and widens blood vessels. This can make it useful for people with congestive heart failure, though it may also cause blood pressure to drop.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual dose is 200 mg 3 times daily for 1 week, then reduced to 200 mg twice daily, or the minimum dose needed to control the arrhythmia. Amiodarone is usually given in several doses through the day to minimize the stomach upset that is seen more often with higher doses. For this same reason, it is also recommended that Amiodarone be taken with meals.
Dosage for other forms (1)
The recommended starting dose is about 1000 mg over the first 24 hours of therapy, given by the following infusion regimen. First, an initial load of 150 mg per 100 mL (in D5W or Normal Saline) is infused over 10 minutes. This is followed by an infusion of 1 mg per minute for 6 hours, followed by 0.5 mg per minute after that. If breakthrough episodes of VF or hemodynamically unstable VT occur, the initial load described above should be repeated as needed, infused over 10 minutes, and the rate of the maintenance infusion increased to achieve effective suppression of the arrhythmia.
Side Effects
The most serious risks with Cardiron therapy involve the lungs, and these reactions can be fatal. Patients should tell their doctor if they notice cough, fever, or painful breathing. Though rare, fatal liver toxicity has also been reported with Cardiron therapy. Other reported effects include reversible corneal microdeposits, sometimes accompanied by night glare; rarely, impaired vision from optic neuritis; peripheral neuropathy and myopathy, usually reversible after stopping treatment; slow heart rate and conduction disturbances; sensitivity to sunlight and, rarely, lasting skin discolouration; underactive or overactive thyroid; raised liver enzymes; and jaundice, hepatitis, or cirrhosis. Less common complaints include nausea, vomiting, a metallic taste, tremor, sweating, dizziness, headache, sleeplessness, fatigue, hair loss, benign raised pressure in the skull, unsteady movement, rashes, vasculitis, kidney involvement, low platelet count, and haemolytic or aplastic anaemia. Depending on severity, the dose of Cardiron may be reduced, or treatment may need to be stopped altogether.
Cautions & Contraindications
Contraindications
Amiodarone should not be used in patients with cardiogenic shock; severe sinus-node dysfunction that causes marked sinus bradycardia; second- or third-degree atrioventricular block; or a history of bradycardia-induced syncope (unless a pacemaker is fitted). It is also contraindicated in anyone with known hypersensitivity to amiodarone or to any of its components, including iodine.
Pregnancy & Breastfeeding
Pregnancy and Breastfeeding: As a general rule, Amiodarone should be avoided during pregnancy, since oral use of the drug in pregnant women has been linked to reports of hypothyroidism or hyperthyroidism in the newborn. If, despite this, a doctor considers Amiodarone essential, the patient should be made aware of the potential risk to the unborn baby. Whether Amiodarone can be used safely by breastfeeding mothers has not yet been established.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Amiodarone Hydrochloride below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Cardiron 200 mg
What is Cardiron 200 mg Tablet?
Cardiron 200 mg Tablet is a medicine that contains Amiodarone Hydrochloride. It is made by Drug International Unani Ltd. It belongs to the Potassium channel blockers group of medicines.
What is Cardiron used for?
Cardiron is used for: Cardiac Arrhythmia.
What are the side effects of Cardiron?
The most serious risks with Cardiron therapy involve the lungs, and these reactions can be fatal. Patients should tell their doctor if they notice cough, fever, or painful breathing.
Can I take Cardiron during pregnancy or while breastfeeding?
Pregnancy and Breastfeeding: As a general rule, Amiodarone should be avoided during pregnancy, since oral use of the drug in pregnant women has been linked to reports of hypothyroidism or hyperthyroidism in the newborn. If, despite this, a doctor considers Amiodarone essential, the patient should be made aware of the potential risk to the unborn baby. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Cardiron?
Store Amiodarone Hydrochloride below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Cardiron?
Some medicines can interact with Amiodarone Hydrochloride, for example: Clarithromycin, Ledipasvir + Sofosbuvir, Artesunate, Warfarin Sodium, Talazoparib, Tizanidine Hydrochloride. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Cardiron is already among the lowest-priced brands of Amiodarone Hydrochloride at this strength.
Do I need a prescription for Cardiron?
Cardiron is a prescription (Rx) medicine. Take it as your doctor advises.