Pricing
Prices are indicative MRP and may vary by pharmacy. Trend compares against the last recorded price.
All price changes →Indications & Uses
Carboprost Tromethamine is used to terminate pregnancy between the 13th and 20th weeks of gestation. It is given in these conditions related to second trimester abortion: failure of expulsion of the fetus during treatment by another method; premature rupture of membranes in intrauterine methods, with loss of drug and insufficient or absent uterine activity; requirement of a repeat intrauterine instillation of drug for expulsion of the fetus; and inadvertent or spontaneous rupture of membranes in the presence of a previable fetus and absence of adequate activity for expulsion. It is also used to treat postpartum hemorrhage caused by the uterus failing to return to its normal size, in patients who have not responded to conventional treatments.
Pharmacology
Carboprost tromethamine, given by intramuscular injection, makes the gravid uterus contract in a way that is similar to the contractions of labor at the end of a full term pregnancy. Nobody has yet determined whether these contractions come from a direct effect of carboprost on the myometrium. Even so, in most cases they empty the products of conception from the uterus.
Postpartum, the myometrial contractions that follow provide hemostasis at the site of placentation.
Carboprost tromethamine also stimulates the smooth muscle of the human gastrointestinal tract. This can cause vomiting, diarrhea or both, and these are common when the medicine is used to terminate pregnancy and for postpartum use.
In laboratory animals and in humans, carboprost tromethamine can raise body temperature. At the clinical doses used to terminate pregnancy and for postpartum use, some patients do have transient temperature increases.
Large doses can raise blood pressure in laboratory animals and in humans, probably by contracting the vascular smooth muscle. At the doses used for terminating pregnancy, this effect has not been clinically significant.
The original also says again that carboprost tromethamine can elevate body temperature in laboratory animals and in humans, and that some patients do experience temperature increases with the clinical doses used for the termination of pregnancy.
In some patients, carboprost tromethamine may cause transient bronchoconstriction.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Abortion
For abortion, the first dose of Carboprost Tromethamine is 1 ml (equal to 250 mcg of Carboprost), given by intramuscular injection. After that, give further doses of 250 mcg at intervals of 1½ to 3½ hours, depending on how the uterus responds. A test dose of 100 mcg (0.4 ml) may be given first if wanted. If the uterine contractions are judged to be inadequate after several doses of 250 mcg (1 ml), the dose may be raised to 500 micrograms (2 ml). The total dose of Carboprost Tromethamine should not go above 12 mg, and giving it continuously for more than 2 days is not recommended.
For Refractory Postpartum Uterine Bleeding
The first dose is 250 mcg (1 ml), given deep intramuscularly (IM). If needed, the 1 ml dose may be repeated after 15 to 90 minutes. The total dose should not exceed 2 mg (8 doses).
Side Effects
Most of the common side effects of Carboprost Tromethamine come from its contracting effect on smooth muscle. So the stomach and bowel are affected most often, and people get vomiting, nausea, diarrhoea and pyrexia. After an abortion done with Carboprost Tromethamine, the complications seen most often are endometritis, retained placental fragments and excessive uterine bleeding.
Cautions & Contraindications
Warnings & Precautions
Carboprost Tromethamine should be given only by medically trained staff, in a hospital that can provide immediate intensive care and acute surgical facilities. Take extra care in patients with a history of asthma, low or high blood pressure, cardiovascular, kidney or liver disease, anemia, jaundice, diabetes or epilepsy, and in those with a compromised (scarred) uterus. In a few patients with chorioamnionitis, the uterus may not respond to Carboprost Tromethamine. The cervix should always be examined carefully straight after an abortion.
Pregnancy & Breastfeeding
Carboprost is in pregnancy category C. Animal studies don't show that it causes birth defects (it is not teratogenic). It has, however, been shown to be toxic to the embryo in rats and rabbits. Any dose that raises the tone of the uterus could also put the embryo or fetus at risk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Carboprost Tromethamine in a refrigerator at 2 to 8°C. Don't let it freeze, and keep it away from light. Once an ampoule has been opened, use the contents straight away.
Common questions about Carbestop 250 mcg/ml
What is Carbestop 250 mcg/ml Injection?
Carbestop 250 mcg/ml Injection is a medicine that contains Carboprost Tromethamine. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Drugs acting on the Uterus group of medicines.
What is Carbestop used for?
Carboprost Tromethamine is used to terminate pregnancy between the 13th and 20th weeks of gestation. It is given in these conditions related to second trimester abortion: failure of expulsion of the fetus during treatment by another method; premature rupture of membranes in intrauterine methods, with loss of drug and insufficient or absent uterine activity; requirement of a repeat intrauterine instillation of drug for expulsion of the fetus; and inadvertent or spontaneous rupture of membranes in the presence of a previable fetus and absence of adequate activity for expulsion.
What are the side effects of Carbestop?
Most of the common side effects of Carboprost Tromethamine come from its contracting effect on smooth muscle. So the stomach and bowel are affected most often, and people get vomiting, nausea, diarrhoea and pyrexia.
Can I take Carbestop during pregnancy or while breastfeeding?
Carboprost is in pregnancy category C. Animal studies don't show that it causes birth defects (it is not teratogenic). Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Carbestop?
Keep Carboprost Tromethamine in a refrigerator at 2 to 8°C. Don't let it freeze, and keep it away from light.
Do I need a prescription for Carbestop?
Carbestop is a prescription (Rx) medicine. Take it as your doctor advises.