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Indications & Uses
Caprolex is used to treat excessive bleeding after surgery, especially in procedures where significant blood loss is expected, such as cardiac surgery. It can be given by mouth or by injection into a vein. A meta-analysis found that lysine analogs like Caprolex significantly reduced blood loss in patients undergoing coronary artery bypass grafting. Caprolex can also be used to treat overdose or toxic effects from the thrombolytic medicines tissue plasminogen activator and streptokinase.
Pharmacology
The fibrinolysis-inhibiting effect of aminocaproic acid comes mainly from its ability to block plasminogen activators, with a smaller contribution from direct antiplasmin activity.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage of Aminocaproic acid must be adjusted to the individual case according to the severity of the bleeding episode. It should be kept in mind that Aminocaproic acid is cleared rapidly through the kidneys, so administration must be repeated every 4 to 6 hours. The average dose is 8 to 16 grams a day, that is, 1 ampule of Aminocaproic acid depending on the case, every 6 hours. Aminocaproic acid is equally effective when taken by mouth or given by intravenous injection. In particularly severe cases, or when a high blood concentration needs to be reached quickly, it is advisable to begin treatment intravenously, with a slow injection of two Aminocaproic acid ampules 30 to 60 minutes apart, then continuing with divided doses until a total of 20 to 25 grams is reached over 24 hours. In all cases, the drug should be continued until all symptoms have completely resolved. Aminocaproic acid may be given intravenously after suitable dilution in physiological saline solution.
Side Effects
Mild muscle pain or weakness, headache, and tiredness can occur. Some people notice nausea, vomiting, stomach pain, or diarrhea. In men, the amount of semen released during orgasm may decrease. A stuffy nose and watery eyes are also possible, along with vision changes or ringing in the ears. A mild skin rash may develop as well.
Cautions & Contraindications
Warnings & Precautions
Safety and effectiveness in patients under 18 years of age have not been established.
Contraindications
Aminocaproic acid should not be given if there is any evidence of an active clotting process within the blood vessels. If it isn't clear whether bleeding is due to primary fibrinolysis or disseminated intravascular coagulation (DIC), this needs to be sorted out before Aminocaproic Acid Injection is given, since the two conditions call for different management. A few tests can help tell them apart. Platelet count is typically low in DIC but stays normal in primary fibrinolysis. The protamine paracoagulation test comes back positive in DIC, seen as a precipitate forming when protamine sulfate is added to citrated plasma, whereas it is negative in primary fibrinolysis. The euglobulin clot lysis test, on the other hand, is abnormal in primary fibrinolysis but normal in DIC. If DIC is present, Aminocaproic Acid Injection should not be given unless heparin is administered alongside it.
Pregnancy & Breastfeeding
Pregnancy Category C. No animal reproduction studies have been carried out with aminocaproic acid, and it is not known whether the drug can harm the fetus when given to a pregnant woman, or whether it can affect fertility. For this reason, Aminocaproic Acid Injection should be used during pregnancy only if there is a clear need for it.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Aminocaproic Acid in a cool, dry place and away from light. If you have the suspension, store it below 30° C. Always keep it out of reach of children.
Common questions about Caprolex 1 gm/5 ml
What is Caprolex 1 gm/5 ml Injection?
Caprolex 1 gm/5 ml Injection is a medicine that contains Aminocaproic Acid. It is made by Techno Drugs Ltd., Satipara, Narshingdi. It belongs to the Anti-fibrinolytic drugs group of medicines.
What is Caprolex used for?
Caprolex is used to treat excessive bleeding after surgery, especially in procedures where significant blood loss is expected, such as cardiac surgery. It can be given by mouth or by injection into a vein.
What are the side effects of Caprolex?
Mild muscle pain or weakness, headache, and tiredness can occur. Some people notice nausea, vomiting, stomach pain, or diarrhea.
Can I take Caprolex during pregnancy or while breastfeeding?
Pregnancy Category C. No animal reproduction studies have been carried out with aminocaproic acid, and it is not known whether the drug can harm the fetus when given to a pregnant woman, or whether it can affect fertility. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Caprolex?
Keep Aminocaproic Acid in a cool, dry place and away from light. If you have the suspension, store it below 30° C.
Do I need a prescription for Caprolex?
Caprolex is a prescription (Rx) medicine. Take it as your doctor advises.