Pricing
Prices are indicative MRP and may vary by pharmacy. Trend compares against the last recorded price.
All price changes →Save on this medicine
Same active ingredient — pay up to 1% less
These brands contain the same active ingredient (Amlodipine Besilate + Benazepril Hydrochloride). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Camlopril
Other strengths and forms by Square Pharmaceuticals PLC, Pabna
Indications & Uses
Camlopril is indicated for:
Pharmacology
The combination of Amlodipine and Benazepril is used to treat high blood pressure. Benazepril and benazeprilat inhibit angiotensin-converting enzyme (ACE), as shown in human subjects and in animals. Benazepril is believed to lower blood pressure mainly by suppressing the renin-angiotensin aldosterone system, but it also has an antihypertensive effect in patients with low-renin hypertension.
Amlodipine is a dihydropyridine calcium antagonist (also called a calcium ion antagonist or slow channel blocker). It inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. It does this selectively, and the effect is greater on vascular smooth muscle cells than on cardiac muscle cells. Amlodipine is a peripheral arterial vasodilator. It acts directly on vascular smooth muscle, which reduces peripheral vascular resistance and so lowers blood pressure.
The rate and extent of absorption of Benazepril and Amlodipine from this capsule are not significantly different from those seen with the individual tablet formulations. After oral administration of the capsule, peak plasma concentrations of Benazepril are reached in 0.5 to 2 hours. For Amlodipine, peak plasma concentrations come 6 to 12 hours after administration, and the extent of absorption is 64% to 90%.
Over 700 patients took Benazepril/Amlodipine once daily in five double-blind, placebo-controlled studies. Blood pressure fell within 1 hour, with the greatest reductions 2 to 8 hours after dosing. The effect of a single dose lasted for 24 hours. With once-daily doses of Benazepril 10-20 mg and Amlodipine 2.5-10 mg, seated pressure (systolic/diastolic) was lower by about 10-25/6-13 mmHg at 24 hours after dosing.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Amlodipine works well for hypertension in once-daily doses of 2.5 to 10 mg, while Benazepril works well in doses of 10 to 80 mg. Treatment with this Amlodipine and Benazepril capsule is usually started only after a patient has not reached the desired blood pressure control with one or the other as monotherapy. It may also be started when Amlodipine therapy alone has not given adequate control without causing edema.
Dose Titration Guided by Clinical Effect
A patient whose blood pressure is not adequately controlled with Amlodipine (or another dihydropyridine) alone, or with Benazepril (or another ACE inhibitor) alone, may be switched to combination therapy with this capsule. All patient groups benefit from the reduction in Amlodipine-induced edema. The dose must be guided by the clinical response. Steady-state levels of Benazepril and Amlodipine are reached after approximately 2 and 7 days of dosing respectively.
Some patients have their blood pressure adequately controlled with Amlodipine but get unacceptable edema. In them, combination therapy may give similar (or better) blood pressure control without the edema. Especially in nonblacks, it may be prudent to reduce the dose of Amlodipine as Benazepril is added to the regimen, to minimize the risk of an excessive response.
Replacement Therapy
For convenience, patients who take Amlodipine and Benazepril as separate tablets may instead take this capsule containing the same component doses. In small, elderly or hepatically impaired patients, the recommended initial dose of Amlodipine is 2.5 mg, whether it is given as monotherapy or as a component of combination therapy.
Side Effects
Benazepril/Amlodipine has been studied for safety in patients with hypertension for at least 6 months, and in some for more than 1 year. The side effects reported were generally mild and short-lived, and they had no relationship with age, sex, race or how long the patient took the treatment. About 4% of patients on Benazepril/Amlodipine had to stop treatment because of side effects, compared with 3% of patients on placebo. In the U.S. studies, the most common reasons for stopping were cough and edema. In U.S. placebo-controlled trials, the side effects considered possibly or probably related to the study drug and seen in more than 1% of patients on Benazepril/Amlodipine were cough, headache, dizziness and edema. Edema was statistically more common in patients on Amlodipine alone than in those on the combination. Edema and some other side effects depend on the dose of Amlodipine when it is given alone, and they appear to affect women more than men. Adding Benazepril lowered how often they occurred, as shown in the study. This protective effect of Benazepril did not depend on race or, within the range of doses tested, on dose. Other rare side effects are angioedema, asthenia, fatigue, insomnia, nervousness, anxiety, tremor, decreased libido, flushing, hot flashes, rash, skin nodule, dermatitis, dry mouth, nausea, abdominal pain, constipation, diarrhea, dyspepsia, esophagitis, hypokalemia, pharyngitis and so on.
Cautions & Contraindications
Warnings & Precautions
Impaired renal function: Use this Amlodipine Besilate + Benazepril Hydrochloride capsule with caution in patients with severe renal disease. Hyperkalemia: This may happen in only a few patients, and it is generally reversible. Patients with hepatic failure: Amlodipine is extensively metabolized by the liver, and in patients with impaired hepatic function its plasma elimination half-life (t ½) is 56 hours. So be careful when giving this capsule to patients with severe hepatic impairment. Cough: ACE inhibitor-induced cough should be considered in the differential diagnosis of cough. Surgery/Anesthesia: In patients undergoing surgery, or during anesthesia with agents that produce hypotension, Benazepril will block the angiotensin II formation that could otherwise occur secondary to compensatory renin release. Hypotension that comes from this mechanism can be corrected by volume expansion. Carcinogenesis, mutagenesis and impairment of fertility: No evidence of carcinogenicity, mutagenicity or impairment of fertility was found when the Benazepril/Amlodipine combination was given orally.
Contraindications
Don't give this capsule to anyone who is hypersensitive to Benazepril, to any other ACE inhibitor, or to Amlodipine.
Pregnancy & Breastfeeding
Pregnancy categories: C in the first trimester, and D in the second and third trimesters. ACE inhibitors can cause illness and death in the unborn baby and the newborn when a pregnant woman takes them. Several dozen cases have been reported in the world literature. So if pregnancy is detected, this capsule should be stopped as soon as possible.
Only minimal amounts of unchanged Benazepril and of benazeprilat pass into the breast milk of nursing mothers treated with Benazepril. A newborn who feeds on nothing but breast milk would receive less than 0.1% of the mother's dose of Benazepril and benazeprilat. It isn't known whether Amlodipine passes into human milk. Since this information is missing, nursing should be stopped while the mother takes this capsule.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Geriatric Use: In clinical experience with Amlodipine Besilate + Benazepril Hydrochloride, no differences in response have been found between elderly and younger patients. Still, some older people may be more sensitive to the medicine, and this cannot be ruled out.
Pediatric Use: Safety and effectiveness in children have not been established.
Overdose
No cases of overdose in humans have been reported with any combination of Amlodipine and Benazepril. There are a few scattered reports of overdose with Benazepril and other ACE inhibitors, and none of them mention a death.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep below 25°C, away from light and moisture. Keep out of the reach of children.
Drug Interactions
Common questions about Camlopril 5 mg+20 mg
What is Camlopril 5 mg+20 mg Capsule?
Camlopril 5 mg+20 mg Capsule is a medicine that contains Amlodipine Besilate + Benazepril Hydrochloride. It is made by Square Pharmaceuticals PLC, Pabna. It belongs to the Combined antihypertensive preparations group of medicines.
What is Camlopril used for?
Camlopril is used for: Hypertension.
What are the side effects of Camlopril?
Benazepril/Amlodipine has been studied for safety in patients with hypertension for at least 6 months, and in some for more than 1 year. The side effects reported were generally mild and short-lived, and they had no relationship with age, sex, race or how long the patient took the treatment.
Can I take Camlopril during pregnancy or while breastfeeding?
Pregnancy categories: C in the first trimester, and D in the second and third trimesters. ACE inhibitors can cause illness and death in the unborn baby and the newborn when a pregnant woman takes them. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Camlopril?
No cases of overdose in humans have been reported with any combination of Amlodipine and Benazepril. There are a few scattered reports of overdose with Benazepril and other ACE inhibitors, and none of them mention a death. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Camlopril?
Keep below 25°C, away from light and moisture. Keep out of the reach of children.
Can I take other medicines with Camlopril?
Some medicines can interact with Amlodipine Besilate + Benazepril Hydrochloride, for example: Spironolactone, Naproxen, Digoxin, Nitroglycerin, Cimetidine, Amlodipine. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Benadip by Incepta Pharmaceuticals Ltd. has the same ingredient and strength for ৳8.00 per unit, compared with ৳8.06 for Camlopril. Ask your doctor or pharmacist before switching.
Do I need a prescription for Camlopril?
Camlopril is a prescription (Rx) medicine. Take it as your doctor advises.