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Silver Sulfadiazine cream is used on the skin to help prevent bacterial colonization and infection in burn wounds. Doctors also use it for the topical antibacterial management of certain contaminated or infection-prone wounds that are not burns.
Pharmacology
Exactly how Silver Sulfadiazine kills bacteria hasn't been fully worked out. After the bacteria are exposed to the drug, their cell membrane changes: the cell becomes distorted and enlarged, and the cell wall membrane gets weaker. Sensitive strains also become less viable. The silver sulfadiazine molecule breaks apart, and the silver part binds to the bacterial cells. The belief is that once the silver part has passed through the cell wall, it attaches to deoxyribonucleic acid (DNA) and stops the bacteria from multiplying.
Mammalian cells contain approximately 100 times more DNA than bacterial cells. So it is thought that the ratio of silver sulfadiazine to bacterial DNA is high enough to stop bacterial division, while the ratio to epithelial DNA is low enough that epithelial cells can still regenerate. The sulfadiazine part adds a bacteriostatic action against sensitive organisms as well.
In adults, up to 10% of the sulfadiazine may be absorbed, and 60 to 85% of the absorbed amount is passed out in the urine. In children with burns covering 13% of body surface area, the urinary sulfadiazine concentration was 31.8 mg/L.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The burn wound is cleaned first, and then Silver Sulfadiazine is applied over it. The burn areas should stay covered with Silver Sulfadiazine at all times. Apply the cream once to twice daily, to a thickness of about 1/16 inches or 1.5 mm. If patient activity rubs the cream off any area, put it on again there whenever necessary. Dressings may be used if the patient's needs make them necessary.
After hydrotherapy, reapply the cream immediately. Continue the treatment until the wound has healed satisfactorily, or until the burn site is ready for grafting. Don't stop the medicine while there is still a possibility of infection, unless a significant adverse reaction occurs.
Side Effects
Several cases of transient leukopenia have been reported in patients using Silver Sulfadiazine. Other side effects are uncommon, and they include skin necrosis, erythema multiforme, skin discoloration, a burning sensation, rashes and interstitial nephritis.
Cautions & Contraindications
Warnings & Precautions
General precautions If liver and kidney function become impaired and the body clears the drug more slowly, Silver Sulfadiazine may build up. In that case, the doctor should weigh stopping it against the benefit the patient is getting from the treatment. Silver Sulfadiazine may also be used together with topical proteolytic enzymes, but silver might inactivate such enzymes, so this possibility should be kept in mind. Laboratory tests When burn wounds cover large areas of the body, serum sulfa concentrations may come close to adult therapeutic levels (8 mg% to 12 mg%). So in these patients it would be advisable to monitor serum sulfa concentrations. Renal function should be monitored carefully, and the urine should be checked for sulfa crystals.
Contraindications
Silver Sulfadiazine must not be used in patients who are hypersensitive to it or to any of the other ingredients in the preparation. It should also not be given to pregnant women who are approaching term or at term, to premature infants, or to newborn infants during the first 2 months of life.
Pregnancy & Breastfeeding
Silver Sulfadiazine is Pregnancy Category B. Use it during pregnancy only if it is clearly justified, and take special care in pregnant women who are approaching term or at term. It is not known whether Silver Sulfadiazine passes into human milk. So a decision has to be made, either to stop nursing or to stop the medicine, depending on how important the medicine is for the mother.
Pediatric Use
Safety and effectiveness in pediatric patients have not been established.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Silver Sulfadiazine below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Burna 1%
What is Burna 1% Cream?
Burna 1% Cream is a medicine that contains Silver Sulfadiazine. It is made by Square Pharmaceuticals PLC, Pabna. It belongs to the Topical Antibiotic preparations group of medicines.
What is Burna used for?
Silver Sulfadiazine cream is used on the skin to help prevent bacterial colonization and infection in burn wounds. Doctors also use it for the topical antibacterial management of certain contaminated or infection-prone wounds that are not burns.
What are the side effects of Burna?
Several cases of transient leukopenia have been reported in patients using Silver Sulfadiazine. Other side effects are uncommon, and they include skin necrosis, erythema multiforme, skin discoloration, a burning sensation, rashes and interstitial nephritis.
Can I take Burna during pregnancy or while breastfeeding?
Silver Sulfadiazine is Pregnancy Category B. Use it during pregnancy only if it is clearly justified, and take special care in pregnant women who are approaching term or at term. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Burna?
Store Silver Sulfadiazine below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Burna?
Some medicines can interact with Silver Sulfadiazine, for example: Phenytoin, Cimetidine, Sulphadiazine. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Burna?
Burna is a prescription (Rx) medicine. Take it as your doctor advises.