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Same active ingredient — pay up to 6% less
These brands contain the same active ingredient (Tranexamic Acid). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Bionex is indicated for:
Pharmacology
This preparation contains tranexamic acid (trans-4 aminomethyl-cyclohexanecarboxylic acid). Tranexamic acid has a strong antifibrinolytic action, and in vivo and in vitro it has proved to be 10 times more active than conventional hemostatics, depending on the test.
Its antihemorrhagic action comes mainly from inhibiting the activation of plasminogen. This applies to exogenous activators like streptokinase and to endogenous ones like urokinase and the plasminogen tissue activator. That matters for clinical use, because it means Tranexamic Acid works against bleeding through an antifibrinolytic mechanism under many different conditions.
The acute toxicity of Tranexamic Acid is extremely low, and chronic toxicity is almost non-existent. It is well absorbed by the oral route, and the effect is already seen 15-30 minutes after administration. It is excreted mainly through the kidneys, but more slowly than conventional hemostatics, so its effect lasts longer. Because of this, considerably lower single doses can be given at greater intervals, and the plasma level doesn't drop to an ineffective antifibrinolytic level between one dose and the next.
At therapeutic doses, Tranexamic Acid does not interfere with the clotting process. Even prolonged administration has not been seen to bring any tendency to thrombophilia.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults: The usual dose is 500 to 1000 mg, three times daily. For prophylaxis, the mean recommended daily dose is 0.5 to 1 gm by mouth, or 500 mg by the parenteral (intravenous or intramuscular) route. For treatment of hemorrhagic manifestations, the oral dose is increased to 1 to 3 gm given in divided doses. In cases of particular seriousness and urgency, treatment may begin with an ampoule (500 mg) injected slowly by the intravenous route, followed by the necessary oral doses.
Children: For prophylaxis, 5 to 10 mg for every kg of body weight is given orally each day in divided doses. For therapeutic purposes, the oral dose is doubled, from 10 to 20 mg/kg, while intravenous or intramuscular treatment is begun with 10 mg/kg (equal to 0.5 ml for every 5 kg) given slowly by the intravenous route, continuing with oral doses up to the amount required. Where more convenient, such as in small babies, the ampoules may be diluted in a little sweetened water and given orally instead of the capsules.
Elderly patients: No reduction in dosage is necessary unless there is evidence of renal failure.
Side Effects
Trexam is generally well tolerated. Some people notice mild, infrequent effects such as tiredness, eye irritation, a blocked nose, itching, or skin redness and rashes. Taken by mouth, it can occasionally cause nausea, diarrhea, or heartburn, and in rare cases a drop in blood pressure on standing up. If you notice any signs of an allergic reaction to Trexam, stop or hold off on treatment and consult your doctor for suitable alternative care.
Cautions & Contraindications
Warnings & Precautions
Trexam is used to treat hyperfibrinolysis. As a preventive treatment, it should be started 24 hours before surgery and continued for 3 to 4 days afterward. When treating bleeding, therapy should be continued for at least 24 hours after symptoms have resolved. In hematuria, particularly when no other bleeding symptoms are present, the dose should be reduced to avoid clot formation in the urinary tract. Trexam must not be used in severe renal insufficiency or anuric conditions, and should be used with caution in milder cases of renal impairment. Patients with heart or liver disease require extra care when taking this medicine.
Contraindications
Known hypersensitivity to the product. Also contraindicated in thromboembolic disease, arterial or venous thrombosis, endocavitary hemorrhage, and severe kidney failure.
Pregnancy & Breastfeeding
Since it is not known whether the drug crosses the placenta or what effect it might have on a developing baby, Tranexamic Acid should not be given during known or suspected pregnancy. Tranexamic Acid does pass into breast milk, but only at roughly one hundredth of the concentration found in the mother's blood, so it is unlikely to have any antifibrinolytic effect on the infant.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Tranexamic Acid in a dry place at 15 to 30°C, away from light. Keep it out of children's reach.
Drug Interactions
Common questions about Bionex 500 mg
What is Bionex 500 mg Capsule?
Bionex 500 mg Capsule is a medicine that contains Tranexamic Acid. It is made by Biopharma Ltd. It belongs to the Anti-fibrinolytic drugs group of medicines.
What is Bionex used for?
Bionex is used for: Cancer.
What are the side effects of Bionex?
Trexam is generally well tolerated. Some people notice mild, infrequent effects such as tiredness, eye irritation, a blocked nose, itching, or skin redness and rashes.
Can I take Bionex during pregnancy or while breastfeeding?
Since it is not known whether the drug crosses the placenta or what effect it might have on a developing baby, Tranexamic Acid should not be given during known or suspected pregnancy. Tranexamic Acid does pass into breast milk, but only at roughly one hundredth of the concentration found in the mother's blood, so it is unlikely to have any antifibrinolytic effect on the infant. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Bionex?
Keep Tranexamic Acid in a dry place at 15 to 30°C, away from light. Keep it out of children's reach.
Can I take other medicines with Bionex?
Some medicines can interact with Tranexamic Acid, for example: Streptokinase, Benzyl Penicillin, Urokinase, Amino Acid. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Klokap by Doctor Tims Pharmaceuticals Ltd. has the same ingredient and strength for ৳15.00 per unit, compared with ৳16.00 for Bionex. Ask your doctor or pharmacist before switching.
Do I need a prescription for Bionex?
Bionex is a prescription (Rx) medicine. Take it as your doctor advises.