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Besigen is indicated for:
Pharmacology
Besifloxacin is an 8-chloro fluoroquinolone bearing an N-1 cyclopropyl group. It works against both Gram-positive and Gram-negative bacteria by blocking two enzymes bacteria need to survive: DNA gyrase, which is essential for replicating, transcribing and repairing bacterial DNA, and topoisomerase IV, which is essential for separating chromosomal DNA when bacterial cells divide.
In a study of adult patients with suspected bacterial conjunctivitis, plasma levels of Besifloxacin were measured after the drug was applied to both eyes three times a day for a total of 16 doses. After both the first and the last dose, no patient's peak plasma concentration exceeded 1.3 ng/ml. On average, the peak concentration was 0.37 ng/ml on day 1 and 0.43 ng/ml on day 6. With repeated dosing, Besifloxacin's average elimination half-life in plasma was about 7 hours.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults and children (1 year of age and older): Instill one drop in the affected eye(s) 3 times a day for 7 days.
Pediatric use: The safety and effectiveness of Besifloxacin in infants below one year of age have not been established. The efficacy of Besifloxacin in treating bacterial conjunctivitis in pediatric patients one year or older has been demonstrated in controlled clinical trials.
Geriatric use: No overall differences in safety and effectiveness have been observed between elderly and younger patients.
Side Effects
The most commonly reported eye-related side effect is conjunctival redness, seen in about 2% of patients. Other side effects reported in about 1% to 2% of patients receiving Besiven include blurred vision, eye pain, eye irritation, itching of the eye, and headache.
Cautions & Contraindications
Warnings & Precautions
Besiven is intended for topical use in the eye only. It must not be injected beneath the conjunctiva or introduced directly into the anterior chamber of the eye. As with other anti-infective medicines, prolonged use may lead to overgrowth of organisms that are not susceptible to the drug, including fungi. If a superinfection develops, stop using the medicine and begin alternative treatment. To avoid contamination, do not let the tip of the dropper touch the eye, the eyelid or any other surface of the affected eye. Contact lenses should not be worn during the course of treatment with Besiven. Shake the bottle well before each use.
Contraindications
Known allergy to besifloxacin or any other ingredient in this product.
Pregnancy & Breastfeeding
Pregnancy Category C. There are no adequate, well-controlled studies of besifloxacin use in pregnant women. It is not known whether besifloxacin passes into human breast milk, though this is presumed to happen. Nursing mothers should use it with caution.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Besifloxacin at room temperature, away from light and moisture. Try not to use the contents more than one month after you first open the bottle. Shake the bottle well before each use.
Common questions about Besigen 0.6%
What is Besigen 0.6% Ophthalmic Suspension?
Besigen 0.6% Ophthalmic Suspension is a medicine that contains Besifloxacin. It is made by General Pharmaceuticals Ltd. It belongs to the Ophthalmic antibacterial drugs group of medicines.
What is Besigen used for?
Besigen is used for: Conjunctivitis.
What are the side effects of Besigen?
The most commonly reported eye-related side effect is conjunctival redness, seen in about 2% of patients. Other side effects reported in about 1% to 2% of patients receiving Besiven include blurred vision, eye pain, eye irritation, itching of the eye, and headache.
Can I take Besigen during pregnancy or while breastfeeding?
Pregnancy Category C. There are no adequate, well-controlled studies of besifloxacin use in pregnant women. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Besigen?
Keep Besifloxacin at room temperature, away from light and moisture. Try not to use the contents more than one month after you first open the bottle.
Do I need a prescription for Besigen?
Besigen is a prescription (Rx) medicine. Take it as your doctor advises.