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Other brands with the same active ingredient
These brands contain the same active ingredient (Baricitinib). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Baritinib 2 is indicated for:
Pharmacology
Baricitinib is a selective and reversible inhibitor of Janus kinase JAK1 and JAK2. Janus kinases (JAKs) are enzymes that pass signals from receptors on the cell surface into the cell. These signals come from a number of cytokines and growth factors that are involved in haematopoiesis, inflammation and immune function. Inside the cell, JAKs phosphorylate and activate signal transducers and activators of transcription (STATs), and the STATs then switch on gene expression within the cell. Baricitinib modulates these signalling pathways by partially inhibiting the enzymatic activity of JAK1 and JAK2, so the phosphorylation and activation of STATs is reduced.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended adult dose of Baricitinib is 2 mg once daily. You can use it on its own or together with Methotrexate or other Disease-modifying antirheumatic drugs (DMARDS). Baricitinib can be taken by mouth, with or without food.
Pediatric use: The safety and effectiveness of Baricitinib in pediatric patients have not been established.
Geriatric use: Elderly patients are more likely to have decreased renal function, so care should be taken when choosing the dose.
Hepatic impairment: No dose adjustment is needed in patients with mild or moderate hepatic impairment.
Renal impairment: Baricitinib is not recommended for patients with an estimated GFR of less than 60 mL/min/I .73 m2.
Side Effects
The most commonly reported adverse drug reactions (ADRs) with Baricitinib, seen in 2% of patients treated with it alone or together with conventional synthetic DMARDs, were increased LDL cholesterol (33.6%), upper respiratory tract infections (14.7%) and nausea (2.8%).
Cautions & Contraindications
Warnings & Precautions
Don't use Baricitinib in a patient who has an active, serious infection, and that includes localized infections. It also should not be given to anyone with active TB. In a patient with a known malignancy, the risks and benefits of treatment should be weighed before starting. The one exception is a successfully treated non-melanoma skin cancer (NMSC). The same weighing of risks and benefits applies when the question is whether to continue Baricitinib in a patient who develops a malignancy, including lymphoproliferative disorders. Use the medicine with caution in patients who may be at increased risk of thrombosis. The same caution applies to patients who may be at increased risk of gastrointestinal perforation. It is to be dispensed only on the prescription of a registered physician.
Contraindications
Anemia: don't start Baricitinib, or stop it if the patient is already taking it, when hemoglobin is less than 8 g/dL. Lymphopenia: don't start Baricitinib, or stop it if the patient is already taking it, when the Absolute Lymphocyte Count is less than 500 cells/mm3. Neutropenia: don't start Baricitinib, or stop it if the patient is already taking it, when the Absolute Neutrophil Count is less than 1000 cells/mm3.
Pregnancy & Breastfeeding
Baricitinib must not be used during pregnancy. As for breastfeeding, there is no information on whether baricitinib passes into human milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
If someone takes too much baricitinib, they should be watched for any signs and symptoms of adverse reactions. Anyone who develops an adverse reaction should be given suitable treatment.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Baricitinib at or below 30°C. Keep it away from light and from damp places. Keep it out of reach of children.
Common questions about Baritinib 2 2 mg
What is Baritinib 2 2 mg Tablet?
Baritinib 2 2 mg Tablet is a medicine that contains Baricitinib. It is made by Healthcare Pharmaceuticals Ltd. It belongs to the Immunosuppressant group of medicines.
What is Baritinib 2 used for?
Baritinib 2 is used for: Rheumatoid Arthritis.
What are the side effects of Baritinib 2?
The most commonly reported adverse drug reactions (ADRs) with Baricitinib, seen in 2% of patients treated with it alone or together with conventional synthetic DMARDs, were increased LDL cholesterol (33.6%), upper respiratory tract infections (14.7%) and nausea (2.8%).
Can I take Baritinib 2 during pregnancy or while breastfeeding?
Baricitinib must not be used during pregnancy. As for breastfeeding, there is no information on whether baricitinib passes into human milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Baritinib 2?
If someone takes too much baricitinib, they should be watched for any signs and symptoms of adverse reactions. Anyone who develops an adverse reaction should be given suitable treatment. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Baritinib 2?
Store Baricitinib at or below 30°C. Keep it away from light and from damp places.
Do I need a prescription for Baritinib 2?
Baritinib 2 is a prescription (Rx) medicine. Take it as your doctor advises.