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Indications & Uses
Azonam is indicated for:
Pharmacology
Aztreonam is a synthetic monobactam antibiotic that kills bacteria by stopping the synthesis of their cell walls. It works by binding strongly to penicillin binding protein 3 (PBP3), which blocks the final stage of peptidoglycan crosslinking, the process that holds the bacterial cell wall together. With PBP3 blocked, the bacterium's own cell wall enzymes, known as autolysins, go on to break down the wall and cause the cell to rupture. Aztreonam may also work by interfering with a natural inhibitor of these autolysins.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults: For urinary tract infections, moderately severe systemic infections, and severe systemic or life-threatening infections, the recommended dosage is 500 mg to 1 g every 8 to 12 hours, 1 g to 2 g every 8 to 12 hours, and 2 g every 6 to 8 hours respectively. Children: For mild to moderate infections (over 1 week of age) and moderate to severe infections (2 years of age or older), the recommended dosage is 30 mg/kg every 6 hours and 50 mg/kg every 6 to 8 hours respectively. The maximum recommended dose for adults is 8 g per day, and the maximum recommended dose for pediatric patients is 120 mg/kg per day. Pediatric use: Dosage information is not yet available for newborns less than one week old.
Side Effects
Local reactions such as phlebitis or thrombophlebitis can follow an IV dose, and discomfort or swelling at the injection site can follow an IM dose. Systemic reactions like diarrhea, nausea and/or vomiting, and rash may also occur. Other side effects include anaphylaxis, angioedema, bronchospasm, pancytopenia, neutropenia, thrombocytopenia, anemia, eosinophilia, leukocytosis, thrombocytosis, abdominal cramps, dermatitis, urticaria, pruritus, hypotension, flushing, seizure, weakness, headache, fever, and malaise.
Cautions & Contraindications
Warnings & Precautions
In patients with reduced liver or kidney function, doctors should monitor them appropriately while they're on this treatment.
Contraindications
Contraindicated in patients with a known hypersensitivity to Aztreonam or to any other ingredient in this preparation.
Pregnancy & Breastfeeding
Pregnancy Category B. Aztreonam crosses the placenta and reaches the fetal circulation, so it should be used during pregnancy only if the potential benefit justifies the potential risk. It is excreted in breast milk at concentrations that are less than 1% of those found in the mother's serum at the same time. Nursing mothers are advised to temporarily stop breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Aztreonam in a cool, dry place, away from light and moisture. Always keep it, like all medicines, out of the reach of children.
Drug Interactions
Common questions about Azonam 1 gm/5 ml
What is Azonam 1 gm/5 ml IM/IV Injection?
Azonam 1 gm/5 ml IM/IV Injection is a medicine that contains Aztreonam. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Other beta-lactam antibiotics group of medicines.
What is Azonam used for?
Azonam is used for: Pneumonia, Bronchitis, Bacterial Infection, Urinary Tract Infection, Respiratory Tract Infection, Sepsis.
What are the side effects of Azonam?
Local reactions such as phlebitis or thrombophlebitis can follow an IV dose, and discomfort or swelling at the injection site can follow an IM dose. Systemic reactions like diarrhea, nausea and/or vomiting, and rash may also occur.
Can I take Azonam during pregnancy or while breastfeeding?
Pregnancy Category B. Aztreonam crosses the placenta and reaches the fetal circulation, so it should be used during pregnancy only if the potential benefit justifies the potential risk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Azonam?
Keep Aztreonam in a cool, dry place, away from light and moisture. Always keep it, like all medicines, out of the reach of children.
Do I need a prescription for Azonam?
Azonam is a prescription (Rx) medicine. Take it as your doctor advises.