Avintol
Rx10 mg • Injection
More from Avintol
Other strengths and forms by Advanced Chemical Industries PLC.
Indications & Uses
Avintol is indicated for:
Pharmacology
Vinpocetine increases cerebral metabolism, boosting glucose and O2 consumption; it improves the brain's tolerance to hypoxia and shifts glucose metabolism toward the more energetically favourable aerobic pathway, though the anaerobic pathway is increased as well. It raises ATP concentration and the ATP to AMP ratio in the brain and elevates cerebral levels of norepinephrine, dopamine and serotonin.
The drug considerably improves cerebral microcirculation by inhibiting platelet aggregation, lowering pathologically increased blood viscosity, and increasing erythrocyte deformability. It also helps carry O2 into the tissues by reducing the O2 affinity of erythrocytes.
Vinpocetine selectively and markedly increases cerebral blood flow and the brain's share of cardiac output, and it lowers cerebral vascular resistance without affecting systemic circulation, including blood pressure, heart rate, cardiac output and total peripheral resistance. It does not produce a steal phenomenon; instead, it mainly improves blood supply to injured and ischaemic areas while leaving blood flow in healthy areas unchanged, an effect known as inverse steal. It also further increases blood flow that is already raised as a result of hypoxia.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
A daily dose of 20 to 40 mg should be given until symptoms improve, for no longer than 10 days, after which oral treatment should be started. If this approach does not work, infusion treatment should be started instead.
Dosage for other forms (2)
1 to 2 tablets three times a day, with a maintenance dose of 1 tablet three times a day.
The daily starting dose is 20 mg given as a slow drip infusion (2 ampoules in 500 to 1000 ml of infusion solution). This dose may be increased to 1 mg/kg body weight over 3 to 4 days. Treatment should continue for 10 to 14 days depending on how well the patient tolerates it, and the dose should be gradually reduced before treatment is stopped.
Side Effects
Transient low blood pressure and a faster heartbeat may occur.
Cautions & Contraindications
Warnings & Precautions
In the acute stage, treatment starts with injections until symptoms improve, then continues as tablets. In chronic cases, tablets alone are used.
Contraindications
Parenteral use is contraindicated in severe ischaemic heart disease, severe rhythm disorders, and pregnancy.
Pregnancy & Breastfeeding
Vinpocetine should not be used during pregnancy or while breastfeeding (lactation).
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Vinpocetine in a cool, dry place, away from light and moisture.
Drug Interactions
Common questions about Avintol 10 mg
What is Avintol 10 mg Injection?
Avintol 10 mg Injection is a medicine that contains Vinpocetine. It is made by Advanced Chemical Industries PLC. It belongs to the Cerebral vasodilator & Neurosensory oxygenator drugs group of medicines.
What is Avintol used for?
Avintol is used for: Deep Vein Thrombosis, Vertigo, Alzheimer's Disease, Stroke, Glaucoma.
What are the side effects of Avintol?
Transient low blood pressure and a faster heartbeat may occur.
Can I take Avintol during pregnancy or while breastfeeding?
Vinpocetine should not be used during pregnancy or while breastfeeding (lactation). Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Avintol?
Keep Vinpocetine in a cool, dry place, away from light and moisture.
Can I take other medicines with Avintol?
Some medicines can interact with Vinpocetine, for example: Heparin Sodium. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Avintol?
Avintol is a prescription (Rx) medicine. Take it as your doctor advises.