Pricing
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All price changes →Indications & Uses
Avifix contains Nelfinavir and is used to treat HIV infection in patients for whom antiretroviral therapy is appropriate.
Pharmacology
Nelfinavir works by selectively and reversibly blocking HIV-1 protease, an enzyme the virus needs to cut its gag-pol polyprotein into functional pieces. By competing for this enzyme, it stops that cleavage step, so the virus particles that are produced are unable to infect new cells.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For adults, the recommended dose is 1250 mg (five 250 mg tablets) twice daily, or alternatively 750 mg (three 250 mg tablets) three times daily. Nelfinavir should be taken with a meal. Its antiviral activity is enhanced when it is given together with nucleoside analogues, so it is recommended that Nelfinavir be used in combination with nucleoside analogues.
For paediatric patients aged 2 to 13 years, the recommended oral dose of Nelfinavir is 20 to 30 mg/kg per dose, given three times daily with a meal.
Side Effects
The safety of Avifix was studied in more than 1500 patients who received the drug either alone or together with nucleoside analogues. Most side effects were mild. The side effect reported most often by people taking Avifix was diarrhoea, which was usually mild to moderate. The side effects below happened in fewer than 2% of patients taking Avifix in all phase II and III clinical trials. They are listed here because they were considered at least possibly related to the treatment, or their cause was unknown, and they were at least moderate in severity. General: abdominal pain, accidental injury, allergic reaction, asthenia, back pain, fever, headache, malaise, pain, and redistribution or accumulation of body fat. Digestive system: anorexia, dyspepsia, epigastric pain, gastrointestinal bleeding, hepatitis, mouth ulceration, pancreatitis, and vomiting. Haemic and lymphatic system: anaemia, leukopenia, and thrombocytopenia. Metabolic and nutritional: increase in alkaline phosphatase, amylase, creatinine phosphokinase, lactic dehydrogenase, SGOT, SGPT, and gamma glutamyl transpeptidase, hyperlipaemia, hyperuricaemia, hyperglycaemia, hypoglycaemia, dehydration, and abnormal liver function tests. Musculoskeletal system: arthralgia, arthritis, cramps, myalgia, myasthenia, and myopathy. Nervous system: anxiety, depression, dizziness, emotional lability, hyperkinesia, insomnia, migraine, paraesthesia, seizures, sleep disorder, somnolence, and suicide ideation. Respiratory system: dyspnoea, pharyngitis, rhinitis, and sinusitis. Skin and appendages: dermatitis, folliculitis, fungal dermatitis, maculopapular rash, pruritus, sweating, and urticaria. Ophthalmic: acute iritis and eye disorder. Urogenital system: kidney calculi and sexual dysfunction.
Cautions & Contraindications
Warnings & Precautions
Avifix should not be given together with terfenadine, astemizole, cisapride, triazolam, midazolam, ergot derivatives, amiodarone or quinidine. Avifix may affect how the liver breaks down these drugs, which can lead to serious and sometimes life-threatening side effects. During post-marketing surveillance, new onset diabetes mellitus, worsening of existing diabetes mellitus and hyperglycaemia have been reported in HIV-infected patients taking protease inhibitor therapy. Some of these patients needed insulin or oral hypoglycaemic agents started or their doses changed to treat these events. In some cases diabetic ketoacidosis has occurred. In some patients who stopped protease inhibitor therapy, the high blood sugar carried on. General: Avifix is mainly broken down by the liver, so care is needed when giving Avifix to patients with liver impairment. Haemophilia: Increased bleeding has been reported in patients with haemophilia type A and B who were treated with protease inhibitors. This included spontaneous skin haematomas and haemarthrosis. Some patients were given extra factor VIII. In more than half of the reported cases, protease inhibitor treatment was continued or started again. A causal relationship has not been established.
Contraindications
Nelfinavir must not be used in patients known to have a clinically significant hypersensitivity to it or to any of its components. Avifix must not be given together with drugs that rely heavily on the CYP3A enzyme for clearance, when raised plasma levels of those drugs could lead to serious or life-threatening adverse events.
Pregnancy & Breastfeeding
Pregnancy Category B. No adequate, well-controlled studies have been conducted in pregnant women.
Lactation: The US Public Health Service Centers for Disease Control and Prevention advises HIV-infected mothers not to breast-feed, so as to avoid transmitting HIV to the child after birth.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Paediatric use: Nelfinavir has not been studied in children below 2 years of age, so its safety, effectiveness and pharmacokinetics in this age group are not known.
Drug Interactions
Common questions about Avifix 250 mg
What is Avifix 250 mg Tablet?
Avifix 250 mg Tablet is a medicine that contains Nelfinavir. It is made by Beximco Pharmaceuticals Ltd. It belongs to the Drugs for HIV / Anti-retroviral drugs group of medicines.
What is Avifix used for?
Avifix contains Nelfinavir and is used to treat HIV infection in patients for whom antiretroviral therapy is appropriate.
What are the side effects of Avifix?
The safety of Avifix was studied in more than 1500 patients who received the drug either alone or together with nucleoside analogues. Most side effects were mild.
Can I take Avifix during pregnancy or while breastfeeding?
Pregnancy Category B. No adequate, well-controlled studies have been conducted in pregnant women. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Can I take other medicines with Avifix?
Some medicines can interact with Nelfinavir, for example: Palbociclib, Crizotinib, Olaparib, Brigatinib, Tacrolimus Monohydrate, Fluticasone Propionate + Formoterol Fumarate. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Avifix is already among the lowest-priced brands of Nelfinavir at this strength.
Do I need a prescription for Avifix?
Avifix is a prescription (Rx) medicine. Take it as your doctor advises.