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These brands contain the same active ingredient (Atomoxetine Hydrochloride). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Attentin
Other strengths and forms by Unimed Unihealth Pharmaceuticals Ltd.
Indications & Uses
Atomoxetine Hydrochloride capsule is used to treat attention deficit hyperactivity disorder (ADHD), as defined by DSM-IV criteria. It can be given to children aged 6 years and older, to adolescents and to adults.
Pharmacology
Nobody knows exactly how Atomoxetine works in Attention Deficit Hyperactivity Disorder (ADHD). It is thought to be related to selective inhibition of the pre-synaptic nor-epinephrine transporter. After oral use, Atomoxetine is well absorbed, and food has only a minimal effect on this. The body clears it mainly by oxidative metabolism through the cytochrome P450 2D6 (CYP2D6) enzymatic pathway.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Children and Adolescents up to 70 kg Body Weight: Start Atomoxetine at a total daily dose of approximately 0.5 mg/kg. After a minimum of three days, increase it to a target total daily dose of approximately 1.2 mg/kg. This can be given as a single dose in the morning or as evenly divided doses in the morning and late afternoon/early evening. After another two to four weeks, the total daily dose may be raised to a maximum of 1.4 mg/kg in patients who have not had a good enough response. The maximum recommended total daily dose in children and adolescents is 1.4 mg/kg or 100mg, whichever is less.
Children and Adolescents over 70 kg Body Weight and Adults: Start Atomoxetine at a total daily dose of 40mg. After a minimum of three days, increase it to a target total daily dose of approximately 80mg, given either as a single dose in the morning or as evenly divided doses in the morning and late afternoon/early evening. After another two to four weeks, the dose may be raised to a maximum of 100mg in patients who have not had a good enough response. The maximum recommended total daily dose in children and adolescents over 70 kg is 100mg.
Maintenance/Extended Treatment: There is no evidence from controlled trials to show how long a patient with ADHD should be treated with Atomoxetine. It is generally agreed, though, that medicine treatment of ADHD may be needed for extended periods. A physician who chooses to use Atomoxetine for extended periods should re-evaluate from time to time whether the medicine is still useful over the long term for that individual patient.
Pediatric use: The pharmacokinetics of Atomoxetine have not been evaluated in children under 6 years of age.
Side Effects
Atomoxetine Hydrochloride can raise blood pressure and heart rate, and these are very common effects. Common side effects are abdominal pain, rash, dyspepsia, early morning awakening, ejaculation disorder, ejaculation failure, fatigue, lethargy, tachycardia, paraesthesia and chills. Peripheral coldness is uncommon.
Cautions & Contraindications
Warnings & Precautions
Suicidal Ideation and Behaviour In clinical trials, suicidal thoughts (suicidal ideation) were seen statistically more often in children and adolescents treated with Atomoxetine Hydrochloride (5/1357 [0.37%]) than in those given placebo (0/851 [0%]). One patient in this age group on Atomoxetine Hydrochloride reported suicidal behaviour, while no patient on placebo did. Aggressive Behaviour or Hostility There is no conclusive evidence that the medicine causes aggressive behaviour or hostility. Still, in clinical trials these events were seen more often in children and adolescents on Atomoxetine Hydrochloride than in those receiving placebo (overall risk ratio of 1.33, which was not statistically significant). Seizures Pre-clinical and clinical trial data don't suggest that Atomoxetine Hydrochloride is proconvulsive. However, seizures have been reported very rarely in post-marketing spontaneous reports. Use it with caution in patients who have a history of seizures. Cardiovascular Effects Atomoxetine Hydrochloride can affect heart rate and blood pressure. Heart rate and blood pressure should be measured before treatment starts and then periodically during treatment, so that any possible clinically important increases are picked up.
Contraindications
Atomoxetine must not be given to anyone with a known hypersensitivity to it. It should not be taken with monoamine oxidase inhibitors (MAOIs), or within two weeks after stopping an MAOI. In the same way, MAOI treatment should not be started within two weeks after Atomoxetine has been stopped. Other medicines that affect brain monoamine concentrations have caused serious, sometimes fatal, reactions when taken together with MAOIs. These reactions include hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations of vital signs, and mental status changes that range from extreme agitation to delirium and coma. Some cases looked like neuroleptic malignant syndrome. Such reactions may occur when the medicines are given together or close to each other in time. In clinical studies, Atomoxetine was linked with a higher risk of mydriasis, so it is not recommended in patients with narrow angle glaucoma. It is also contra-indicated in patients with severe cardiovascular disorders, symptomatic cardiovascular diseases, uncontrolled hyperthyroidism or phaeochromocytoma.
Pregnancy & Breastfeeding
Atomoxetine is in Pregnancy Category B3. No adequate and well-controlled studies have been done in pregnant women, so doctors should not use Atomoxetine during pregnancy unless the possible benefit justifies the possible risk to the foetus.
Lactation: Atomoxetine and/or its metabolites were found in the milk of rats. It is not known whether Atomoxetine passes into human milk. Caution should be taken if it is given to a nursing woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
With Atomoxetine Hydrochloride, the most commonly reported gastrointestinal symptoms include somnolence, dizziness, tremor and abnormal behaviour. Hyperactivity and agitation have also been reported. Signs and symptoms consistent with mild to moderate activation of the sympathetic nervous system were seen too (for example tachycardia, increased blood pressure, mydriasis and dry mouth). Most events were mild to moderate. In some cases of overdose involving Atomoxetine Hydrochloride, seizures have been reported, and very rarely QT prolongation. Clinical trial experience with overdose is limited. No fatal overdoses occurred in clinical trials.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Atomoxetine Hydrochloride in a cool, dry place, away from light.
Common questions about Attentin 40 mg
What is Attentin 40 mg Capsule?
Attentin 40 mg Capsule is a medicine that contains Atomoxetine Hydrochloride. It is made by Unimed Unihealth Pharmaceuticals Ltd. It belongs to the CNS stimulant drugs group of medicines.
What is Attentin used for?
Atomoxetine Hydrochloride capsule is used to treat attention deficit hyperactivity disorder (ADHD), as defined by DSM-IV criteria. It can be given to children aged 6 years and older, to adolescents and to adults.
What are the side effects of Attentin?
Atomoxetine Hydrochloride can raise blood pressure and heart rate, and these are very common effects. Common side effects are abdominal pain, rash, dyspepsia, early morning awakening, ejaculation disorder, ejaculation failure, fatigue, lethargy, tachycardia, paraesthesia and chills.
Can I take Attentin during pregnancy or while breastfeeding?
Atomoxetine is in Pregnancy Category B3. No adequate and well-controlled studies have been done in pregnant women, so doctors should not use Atomoxetine during pregnancy unless the possible benefit justifies the possible risk to the foetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Attentin?
With Atomoxetine Hydrochloride, the most commonly reported gastrointestinal symptoms include somnolence, dizziness, tremor and abnormal behaviour. Hyperactivity and agitation have also been reported. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Attentin?
Keep Atomoxetine Hydrochloride in a cool, dry place, away from light.
Is there a cheaper medicine with the same ingredient?
Oriham by Incepta Pharmaceuticals Ltd. has the same ingredient and strength for ৳30.00 per unit, compared with ৳35.00 for Attentin. Ask your doctor or pharmacist before switching.
Do I need a prescription for Attentin?
Attentin is a prescription (Rx) medicine. Take it as your doctor advises.