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Indications & Uses
Arsenor is indicated for:
Pharmacology
Apremilast is a novel, orally available small molecule that inhibits type 4 cyclic nucleotide phosphodiesterase (PDE-4). PDE-4 is a cyclic adenosine monophosphate (cAMP) specific phosphodiesterase found mainly in inflammatory cells. By inhibiting PDE-4, apremilast raises intracellular levels of cAMP, which in turn suppresses the production of several proinflammatory mediators, including PDE-4, TNF-alpha, interleukin-2 (IL-2), interferon-gamma, leukotrienes, and nitric oxide synthase. Because it acts on a central component of the inflammatory signaling cascade rather than a single inflammatory marker, PDE-4 inhibition may help restore the natural balance between pro-inflammatory and anti-inflammatory signaling.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Apremilast is started with a five-day dose titration, then continued at the usual maintenance dose of 30 mg taken by mouth twice daily from Day 6 onward. The gradual increase is meant to reduce the stomach and bowel upset that can occur when treatment begins. Apremilast may be taken with or without food. On Day 1, take 10 mg in the morning. On Day 2, take 10 mg in the morning and 10 mg in the evening. On Day 3, take 10 mg in the morning and 20 mg in the evening. On Day 4, take 20 mg in the morning and 20 mg in the evening. On Day 5, take 20 mg in the morning and 30 mg in the evening. From Day 6, take 30 mg twice daily. In patients with severe kidney impairment, the dose should be lowered to 30 mg once daily. For the initial titration in these patients, only the morning doses of the schedule should be taken and the evening doses skipped.
Side Effects
The most common side effects of Aprima are nausea, diarrhoea and headache. Less common side effects include upper respiratory tract infection, vomiting, nasopharyngitis, abdominal pain, hypersensitivity, gastro-oesophageal reflux disease, dyspepsia, fatigue, decreased appetite, cough, rash and insomnia.
Cautions & Contraindications
Warnings & Precautions
Treatment with Aprima is associated with an increase in adverse reactions of depression. Patients, their caregivers and families should be advised of the need to be alert for the emergence or worsening of depression, suicidal thoughts or other mood changes, and to contact their healthcare provider if such changes occur. Prescribers should carefully weigh the risks and benefits of continuing treatment with Aprima if such events occur. During the controlled period of the studies in psoriatic arthritis, a weight decrease of between 5% and 10% of body weight was reported in 10% of subjects treated with Aprima 30 mg twice daily, compared with 3.3% of those treated with placebo.
Contraindications
Apremilast should not be given to anyone who has a known allergy (hypersensitivity) to Apremilast itself or to any other ingredient in the tablet.
Pregnancy & Breastfeeding
Pregnancy Category C. It is not known whether Apremilast or its breakdown products pass into human breast milk, though it has been found in the milk of nursing mice. As a precaution, it should be used carefully in breastfeeding mothers.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Use in paediatric patients: the safety and effectiveness of Apremilast have not been established in patients under 18 years of age.
Storage
Keep Apremilast in a cool, dry place, away from light and moisture. Make sure the medicine stays out of the reach of children.
Drug Interactions
Common questions about Arsenor 10 mg
What is Arsenor 10 mg Tablet?
Arsenor 10 mg Tablet is a medicine that contains Apremilast. It is made by Beacon Pharmaceuticals PLC. It belongs to the Disease-modifying antirheumatic drugs (DMARDs) group of medicines.
What is Arsenor used for?
Arsenor is used for: Psoriasis.
What are the side effects of Arsenor?
The most common side effects of Aprima are nausea, diarrhoea and headache. Less common side effects include upper respiratory tract infection, vomiting, nasopharyngitis, abdominal pain, hypersensitivity, gastro-oesophageal reflux disease, dyspepsia, fatigue, decreased appetite, cough, rash and insomnia.
Can I take Arsenor during pregnancy or while breastfeeding?
Pregnancy Category C. It is not known whether Apremilast or its breakdown products pass into human breast milk, though it has been found in the milk of nursing mice. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Arsenor?
Keep Apremilast in a cool, dry place, away from light and moisture. Make sure the medicine stays out of the reach of children.
Can I take other medicines with Arsenor?
Some medicines can interact with Apremilast, for example: Carbamazepine, Phenytoin, Phenobarbital, Rifampicin. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Arsenor is already among the lowest-priced brands of Apremilast at this strength.
Do I need a prescription for Arsenor?
Arsenor is a prescription (Rx) medicine. Take it as your doctor advises.