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Other brands with the same active ingredient
These brands contain the same active ingredient (Apixaban). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Antixa 2.5 is indicated for:
Pharmacology
Apixaban works by inhibiting coagulation, so it stops blood clots from forming. Because it inhibits FXa, apixaban also lengthens clotting tests such as prothrombin time (PT), INR and activated partial thromboplastin time (aPTT). At the expected therapeutic dose, though, the changes seen in these tests are small and vary a great deal from one person to another. So they are not useful for monitoring the anticoagulation effect of apixaban.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Recommended Dose
Most patients take Apixaban 5 mg orally, twice daily.
Dosage Adjustments
The dose of Apixaban is 2.5 mg twice daily for patients who have any 2 of these characteristics: age 80 years or above, body weight 60 kg or less, serum creatinine 1.5 mg/dl or above.
CYP3A4 and P-gp inhibitors
When Apixaban is given together with drugs that are strong dual inhibitors of cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp), for example ketoconazole, itraconazole, ritonavir and clarithromycin, the recommended dose is 2.5 mg twice daily.
Missed Dose
If a dose of Apixaban isn't taken at the scheduled time, it should be taken as soon as possible on the same day, and then twice-daily dosing should be resumed. The dose should not be doubled to make up for a missed one.
Discontinuation for Surgery and Other Interventions
Apixaban should be discontinued at least 48 hours before elective surgery or invasive procedures that carry a moderate or high risk of unacceptable or clinically significant bleeding. For elective surgery or invasive procedures with a low risk of bleeding, or where the bleeding would be non-critical in location and easily controlled, it should be discontinued at least 24 hours before.
Switching from or to Apixaban
Switching from warfarin to Apixaban
Warfarin should be discontinued, and Apixaban started once the international normalized ratio (INR) is below 2.0.
Switching from Apixaban to warfarin
Apixaban affects INR, so INR measurements while the two are given together may not be useful for working out the right dose of warfarin. If continuous anticoagulation is necessary, discontinue Apixaban and begin both a parenteral anticoagulant and warfarin at the time the next dose of Apixaban would have been taken. The parenteral anticoagulant is then discontinued when the INR reaches an acceptable range.
Switching between Apixaban and anticoagulants other than warfarin
Discontinue the one being taken and begin the other at the next scheduled dose.
Side Effects
Apixaban can cause a skin rash. In some people it can also cause a severe allergic reaction.
Cautions & Contraindications
Warnings & Precautions
Discontinuation of Apixaban can raise the risk of stroke. Discontinuing Apixaban without adequate alternative anticoagulation in place increases the risk of thrombotic events. In clinical trials, patients with nonvalvular atrial fibrillation had a higher rate of stroke during the transition from Apixaban to warfarin. If Apixaban must be discontinued for a reason other than pathological bleeding, consider coverage with another anticoagulant.
Contraindications
Patients should not take Apixaban if they have active pathological bleeding. It is also not for anyone who has had a severe hypersensitivity reaction to Apixaban, such as an anaphylactic reaction.
Pregnancy & Breastfeeding
Pregnancy: There are no adequate and well-controlled studies of Apixaban in pregnant women. Treatment is likely to increase the risk of hemorrhage during pregnancy and delivery. Apixaban should be used in pregnancy only if the potential benefit outweighs the potential risk to the mother and the fetus.
Labor and Delivery: The safety and effectiveness of Apixaban during labor and delivery have not been studied in clinical trials. Think about the risk of bleeding and the risk of stroke when using Apixaban in this situation.
Nursing Mothers: It is unknown whether Apixaban or its metabolites pass into human milk. Women should be told either to stop breastfeeding or to stop Apixaban therapy, taking into account how important the medicine is to the mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Hepatic Impairment
People with mild hepatic impairment don't need a dose adjustment. In moderate hepatic impairment, patients may already have problems with blood clotting, and there is limited clinical experience with Apixa in these patients, so dosing recommendations cannot be given. Apixa is not recommended in patients with severe hepatic impairment.
Renal Impairment
The dose adjustment for moderate renal impairment is described above. No data are available to guide use in patients with creatinine clearance <15 ml/min or in those on dialysis.
Pediatric Use
Safety and effectiveness in pediatric patients have not been established.
Geriatric Use
Of the total subjects in clinical studies of Apixa, >69% were 65 and older, and >31% were 75 and older. Compared with warfarin, the effects of Apixa on the risk of stroke and major bleeding were maintained in geriatric subjects.
Overdose
Apixa has no antidote. If someone takes too much of it, the risk of bleeding goes up. Activated charcoal may help in managing an Apixa overdose.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Apixaban in a dry place, below 30°C. Keep it away from light, and keep it out of the reach of children.
Drug Interactions
Common questions about Antixa 2.5 2.5 mg
What is Antixa 2.5 2.5 mg Tablet?
Antixa 2.5 2.5 mg Tablet is a medicine that contains Apixaban. It is made by General Pharmaceuticals Ltd. It belongs to the Anti-coagulants group of medicines.
What is Antixa 2.5 used for?
Antixa 2.5 is used for: Cardiac Arrhythmia, Deep Vein Thrombosis, Stroke.
What are the side effects of Antixa 2.5?
Apixaban can cause a skin rash. In some people it can also cause a severe allergic reaction.
Can I take Antixa 2.5 during pregnancy or while breastfeeding?
Pregnancy: There are no adequate and well-controlled studies of Apixaban in pregnant women. Treatment is likely to increase the risk of hemorrhage during pregnancy and delivery. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Antixa 2.5?
Apixa has no antidote. If someone takes too much of it, the risk of bleeding goes up. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Antixa 2.5?
Store Apixaban in a dry place, below 30°C. Keep it away from light, and keep it out of the reach of children.
Can I take other medicines with Antixa 2.5?
Some medicines can interact with Apixaban, for example: Ketoprofen. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Antixa 2.5?
Antixa 2.5 is a prescription (Rx) medicine. Take it as your doctor advises.