Indications & Uses
Amphoject IV Injection is indicated for:
Pharmacology
Amphotericin B can be fungistatic or fungicidal, depending on the concentration reached in body fluids and how susceptible the fungus is. It works by binding to sterols (ergosterol) in the cell membrane of susceptible fungi. This creates a transmembrane channel, and the resulting change in membrane permeability allows intracellular components to leak out. Ergosterol, the main sterol in the fungal cytoplasmic membrane, is the site targeted by both amphotericin B and the azoles. As a polyene, amphotericin B binds irreversibly to ergosterol, disrupting membrane integrity and ultimately causing cell death.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For systemic fungal infections, Amphotericin B starts with a test dose of 1 mg IV infused over 20 to 30 min. The load is 0.25 to 0.5 mg/kg IV infused over 2 to 6 hour. Maintenance is 0.25 to 1 mg/kg IV once a day, or up to 1.5 mg/kg IV every other day. The dose may be raised gradually in 0.25 mg increments per day.
Side Effects
Common side effects include fever, chills, convulsions and malaise; nausea, vomiting, diarrhoea and loss of appetite; tinnitus, vertigo and hearing loss; low blood pressure, high blood pressure and irregular heart rhythm; peripheral neuropathy; phlebitis and pain at the injection site; and disturbances in kidney function and kidney toxicity.
Cautions & Contraindications
Warnings & Precautions
As with any Amphotericin B‑containing product, Amphoject should be given by medically trained staff. Patients should be kept under close clinical observation during the initial dosing period. Amphoject has been shown to be significantly less toxic than Amphotericin B deoxycholate; however, adverse events may still occur.
Contraindications
Amphotericin B should not be given to patients with known or previously shown hypersensitivity to amphotericin B deoxycholate or to any other ingredient in the product, unless the treating physician judges that the benefit of treatment outweighs the risk.
Pregnancy & Breastfeeding
Pregnancy Category B. No adequate, well-controlled studies have looked at Amphotericin B use during pregnancy. Whether it passes into human breast milk is also not known.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep unopened vials of Amphotericin B (the freeze-dried powder) at temperatures up to 25°C. Once the powder has been reconstituted, the concentrate can be stored for up to 24 hours at 2 to 8°C.
Drug Interactions
Common questions about Amphoject IV Injection 50 mg
What is Amphoject IV Injection 50 mg Injection?
Amphoject IV Injection 50 mg Injection is a medicine that contains Amphotericin B. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Other Antifungal preparations group of medicines.
What is Amphoject IV Injection used for?
Amphoject IV Injection is used for: Fungal Infection.
What are the side effects of Amphoject IV Injection?
Common side effects include fever, chills, convulsions and malaise; nausea, vomiting, diarrhoea and loss of appetite; tinnitus, vertigo and hearing loss; low blood pressure, high blood pressure and irregular heart rhythm; peripheral neuropathy; phlebitis and pain at the injection site; and disturbances in kidney function and kidney toxicity.
Can I take Amphoject IV Injection during pregnancy or while breastfeeding?
Pregnancy Category B. No adequate, well-controlled studies have looked at Amphotericin B use during pregnancy. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Amphoject IV Injection?
Keep unopened vials of Amphotericin B (the freeze-dried powder) at temperatures up to 25°C. Once the powder has been reconstituted, the concentrate can be stored for up to 24 hours at 2 to 8°C.
Can I take other medicines with Amphoject IV Injection?
Some medicines can interact with Amphotericin B, for example: Cisplatin, Econazole Nitrate + Triamcinolone Acetonide, Lactitol Monohydrate, Neomycin Sulfate + Bacitracin Zinc, Gentamicin + Hydrocortisone Acetate, Teicoplanin. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Amphoject IV Injection?
Amphoject IV Injection is a prescription (Rx) medicine. Take it as your doctor advises.